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NIH awards Georgia malaria research consortium up to $19.4 million contract
Date:11/19/2012

and Infectious Diseases for recognizing the enormous potential of taking a systems biology approach to studying malaria infections," Galinski says.

"This project will help us better understand malaria as a disease in depth and pave the way for new preventive and therapeutic measures. We expect to provide a groundbreaking wealth of information that will address current challenges in fighting malaria. The Georgia team we have assembled is outstanding and we also look forward to working closely with prominent international partners from malaria endemic countries."

A prestigious international Scientific Consultation Group is also involved, and met with the MaHPIC team at Emory recently, following the annual American Society of Tropical Medicine and Hygiene conference held in Atlanta.

The MaHPIC project involves studying both nonhuman primate infections and clinical samples from humans around the world. For the study of malaria, "systems biology" means first collecting comprehensive data on how a Plasmodium parasite infection produces changes in host and parasite genes, proteins, lipids, the immune response and metabolism.

Computational researchers will then design mathematical models to simulate and analyze what's happening during an infection and to find patterns that predict the course of the disease and its severity. Together, the insights will help guide the development of new interventions. Co-infections and morbidities will also come into play, as well as different cultural and environmental backgrounds of the communities involved.

The team will use metabolomics techniques that will allow scientists to detect, analyze and make crucial associations with thousands of chemicals detectable in the blood via mass spectrometry. The techniques were developed at Emory by Dean Jones, PhD, professor and director of the Clinical Biomarkers Laboratory and MaHPIC's metabolomics core leader.

"This is a wonderful opp
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Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

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