Navigation Links
NIH awards $2.5 million to UC for study in voice production

CINCINNATITry to go one week without speaking. Now, imagine going months, or years, without being able to talk to friends or loved ones.

For patients with severe voice disorders, the loss of their voice often means losing their social life, self esteem or livelihood. While existing therapies can treat mild to moderate voice disorders, physicians have a harder time determining effective treatments for those with severe cases.

With a new five-year, $2.5 million grant from the National Institute on Deafness and Other Communication Disorders at the National Institutes of Health, University of Cincinnati (UC) researchers will continue interdisciplinary partnerships to study the causes behind those disorders and the most effective ways to treat them.

The grant, awarded to laryngologist Sid Khosla, MD, of UC's department of otolaryngology, includes aerospace engineer Ephraim Gutmark, PhD, of engineering and otolaryngology, Suzanne Boyce, PhD, of communication sciences & disorders and Shanmugam Murugappan, PhD, of otolaryngology.

The researchers are seeking to prove a new hypothesis about the production of voice: that vortices, or pockets of rotating air near the vocal cords, are necessary for normal voice production. It is the modification or suppression of those vortices in laryngeal disease, researchers think, that leads to abnormal voice.

In normal voice production, or phonation, says Khosla, vocal cords come together while air flowing over them produces vibration. But he says researchers haven't been able to confirm exactly how the air creates the vibration.

Past research points to vortices as the key ingredient. Vortices were known to produce sound in jet engines and suction in tornados, but it wasn't until Khosla and Gutmark developed a method to identify vortices in a larynx that they could measure the forces they produced.

In that research, the team brought in techniques Gutmark had used to study airflow inside jet engines, when the goal was reducing jet noise.

"Now our purpose is different, but the physics is the same," says Gutmark. "Once you understand how airflow structure produces acoustics, you can either make the acoustics quieter, for jets, or make them stronger, for voices."

Khosla and his team will now study how vortices are affected in certain voice pathologies.

Specifically, they will look at treatments for unilateral vocal cord paralysis, a condition that often results in reduced vibrations of the paralyzed vocal cord.

"Often the paralyzed cord is in a position off midline," says Khosla, "so there is a gap between the cords during phonation. This will lead to altered vibration of the paralyzed side or both sides. Altered vibration gives altered sound."

If one of the tested treatments sufficiently restores vortices in the airway, then it could stand the best chance of restoring normal vibrations and normal voice.

"It's not only about determining that these vortices are there and they play a crucial role," says Khosla, "but it's also about determining the best ways to restore them for these patients."


Contact: Katy Cosse
University of Cincinnati Academic Health Center

Related medicine news :

1. Michael J. Fox Foundation Awards $2 Million for Clinical Research on Postural Instability and Gait Disturbances in Parkinsons Disease
2. Healthcare Web Site Wins Top Industry Awards
3. Michael J. Fox Foundation Awards $1 Million for Critical Step Toward Development of Dyskinesia Treatments
4. Crohn's & Colitis Foundation Presents National Science Awards to Clinical and Scientific Thought-Leaders in Inflammatory Bowel Diseases
5. NIH awards La Jolla Institute $18.8 million for major infectious disease study
6. The Venza Group Received Top Honors at the American Society of Training & Development (ASTD) eLearning Excellence Awards Ceremony Held on December 10, 2009
7. Wins National Healthcare Website Awards
8. Ascension Health Hospital Awards Streamline Health Contract to Ensure OSHA Compliance
9. The Kenneth Rainin Foundation Awards $457,000 in Grants to Support Dance, Theater, Film and Early Literacy in the San Francisco Bay Area
10. Tipping Point Community Announces $1 Million Gift at Third Annual Awards Breakfast
11. Wellness Manufacturer Wins Two 2009 American Spa Awards
Post Your Comments:
(Date:11/26/2015)... ... ... Indosoft Inc., developer and distributor of the world-class Asterisk based contact center software Q-Suite, ... The new Q-Suite 6 platform is based on the latest Java Enterprise standards. By ... piece of software for many key components of the suite. Much of the suite ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in the ... several models of traditional and far-infrared saunas. , For traditional saunas, Finnleo ... most traditional Finnish sauna wood, and Finnleo uses only European Grade A Nordic White ...
(Date:11/25/2015)... (PRWEB) , ... November 26, 2015 , ... ... Union Commission (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and ... Office in Nairobi (UNON) for the opening of the 5th African Network for ...
(Date:11/25/2015)... Jacksonville, FL (PRWEB) , ... November 25, 2015 ... ... treatment center, is encouraging people across the country to celebrate their sobriety and ... invites people to post “before and after” photos this Thanksgiving with the hashtag ...
(Date:11/25/2015)... ... November 25, 2015 , ... The McHenry County law firm ... appellate decision obtained by Attorneys Francisco J. Botto and Alex C. Wimmer. Attorneys Botto ... Compensation Comm’n, 2015 IL App (2d) 130884WC. , According to court documents, Adcock testified ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... -- Research and Markets ( ) has announced ... by Type (Dressings, Therapy Devices, Active Wound Care), Application ... and Geography - Global Forecast to 2020" report ... --> The purpose of this report is ... global advanced wound care market. It involves deep dive ...
(Date:11/26/2015)... , November 26, 2015 ... addition of the "Radioimmunoassay Market by ... (Hospital, Pharmaceutical Industry, Academics, Clinical Diagnostic Labs), ... Global Forecast to 2020" report to ... has announced the addition of the ...
(Date:11/25/2015)... 2015  The American Academy of Pediatrics (AAP), ... the March of Dimes cheered today,s signature into ... Act of 2015 (S.799), which takes much-needed ... exposed to drugs, such as opioids, and to ... three organizations have worked together leading advocacy efforts ...
Breaking Medicine Technology: