Navigation Links
NIH awards $2.5 million to UC for study in voice production
Date:12/29/2009

CINCINNATITry to go one week without speaking. Now, imagine going months, or years, without being able to talk to friends or loved ones.

For patients with severe voice disorders, the loss of their voice often means losing their social life, self esteem or livelihood. While existing therapies can treat mild to moderate voice disorders, physicians have a harder time determining effective treatments for those with severe cases.

With a new five-year, $2.5 million grant from the National Institute on Deafness and Other Communication Disorders at the National Institutes of Health, University of Cincinnati (UC) researchers will continue interdisciplinary partnerships to study the causes behind those disorders and the most effective ways to treat them.

The grant, awarded to laryngologist Sid Khosla, MD, of UC's department of otolaryngology, includes aerospace engineer Ephraim Gutmark, PhD, of engineering and otolaryngology, Suzanne Boyce, PhD, of communication sciences & disorders and Shanmugam Murugappan, PhD, of otolaryngology.

The researchers are seeking to prove a new hypothesis about the production of voice: that vortices, or pockets of rotating air near the vocal cords, are necessary for normal voice production. It is the modification or suppression of those vortices in laryngeal disease, researchers think, that leads to abnormal voice.

In normal voice production, or phonation, says Khosla, vocal cords come together while air flowing over them produces vibration. But he says researchers haven't been able to confirm exactly how the air creates the vibration.

Past research points to vortices as the key ingredient. Vortices were known to produce sound in jet engines and suction in tornados, but it wasn't until Khosla and Gutmark developed a method to identify vortices in a larynx that they could measure the forces they produced.

In that research, the team brought in techniques Gutmark had used to study airflow inside jet engines, when the goal was reducing jet noise.

"Now our purpose is different, but the physics is the same," says Gutmark. "Once you understand how airflow structure produces acoustics, you can either make the acoustics quieter, for jets, or make them stronger, for voices."

Khosla and his team will now study how vortices are affected in certain voice pathologies.

Specifically, they will look at treatments for unilateral vocal cord paralysis, a condition that often results in reduced vibrations of the paralyzed vocal cord.

"Often the paralyzed cord is in a position off midline," says Khosla, "so there is a gap between the cords during phonation. This will lead to altered vibration of the paralyzed side or both sides. Altered vibration gives altered sound."

If one of the tested treatments sufficiently restores vortices in the airway, then it could stand the best chance of restoring normal vibrations and normal voice.

"It's not only about determining that these vortices are there and they play a crucial role," says Khosla, "but it's also about determining the best ways to restore them for these patients."


'/>"/>

Contact: Katy Cosse
kathryn.cosse@uc.edu
513-558-0207
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Michael J. Fox Foundation Awards $2 Million for Clinical Research on Postural Instability and Gait Disturbances in Parkinsons Disease
2. Healthcare Web Site Wins Top Industry Awards
3. Michael J. Fox Foundation Awards $1 Million for Critical Step Toward Development of Dyskinesia Treatments
4. Crohn's & Colitis Foundation Presents National Science Awards to Clinical and Scientific Thought-Leaders in Inflammatory Bowel Diseases
5. NIH awards La Jolla Institute $18.8 million for major infectious disease study
6. The Venza Group Received Top Honors at the American Society of Training & Development (ASTD) eLearning Excellence Awards Ceremony Held on December 10, 2009
7. BaylorHealth.com Wins National Healthcare Website Awards
8. Ascension Health Hospital Awards Streamline Health Contract to Ensure OSHA Compliance
9. The Kenneth Rainin Foundation Awards $457,000 in Grants to Support Dance, Theater, Film and Early Literacy in the San Francisco Bay Area
10. Tipping Point Community Announces $1 Million Gift at Third Annual Awards Breakfast
11. Wellness Manufacturer Wins Two 2009 American Spa Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... , ... Providing broad access to life-saving drugs and rewarding the innovators who ... to address this problem. , That was the message from Dana Goldman, PhD, Leonard ... University of Southern California, who served as the keynote speaker for Western University of ...
(Date:4/21/2017)... ... April 21, 2017 , ... Evoke ... young adults, has kicked off its 4th annual Forum for Innovative Treatment Solutions ... is “Attachment Informed Therapy for Mental Health and Addiction.” , FITS’ 2017 ...
(Date:4/21/2017)... ... April 21, 2017 , ... The adage “Show, don’t ... the next project in the company’s esteemed VISION House demonstration project series. Manifesting the ... the amount of resources they need to live affordably and abundantly without unduly taxing ...
(Date:4/21/2017)... ... April 21, 2017 , ... Crossover Symmetry , ... , an active lifestyle company that provides Human Performance Training and education to ... offers, first responders, military officers and others in service through the development and ...
(Date:4/21/2017)... ... April 21, 2017 , ... Northern California Medical ... Care Spring Symposium on April 1, 2017 in Santa Rosa. This well-attended annual ... healthcare providers an opportunity to learn about cutting edge treatments, to collaborate, share ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 /PRNewswire/ - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), ... Healthcare Investor Conference 2017 at the Sheraton Hotel in ... Executive Officer of the Company is scheduled to present on Tuesday, ... and the Chairman of the Board, Tony Holler ... ...
(Date:4/19/2017)... 2017 Global Surgical Drainage Device Market: Overview ... to remove excess liquid and air. The fluid to ... or lymph. Surgical drains are used in a wide ... surgery, cardiovascular surgery, neurosurgery, plastic surgery etc. Common use ... accumulation of fluid e.g. blood or pus. Surgical drains ...
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
Breaking Medicine Technology: