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NIH awards $10M to Einstein for diabetes research
Date:5/25/2010

Spiegel, M.D., the Marilyn and Stanley M. Katz Dean. "This award enables the DRTC to continue its vital role in improving prospects for prevention and treatment of types 1 and 2 diabetes under the new leadership of Dr. Pessin."

Dr. Spiegel added, "The opening of the Michael F. Price Center for Genetic and Translational Medicine/Harold and Muriel Block Research Pavilion has enabled Einstein to augment its strength in diabetes research with the recruitment of Dr. Pessin and several new outstanding diabetes investigators."

The Einstein DRTC supports a variety of basic research projects. Of particular note are studies involving the central nervous system's crucial role in diabetes a field pioneered by Einstein researchers about a decade ago. It's now known that the brain helps in controlling energy expenditure, metabolism, and insulin sensitivity.

Einstein researchers are also recognized for studies of the epigenetics of diabetes and obesity focusing on how environmental factors, such as chemical exposures, influence gene expression and lead to disease. In addition, the DRTC at Einstein has a strong research effort into diabetic complications, with a particular focus on kidney disease.

"The ultimate goal of these studies is to develop new therapies for the prevention or treatment of diabetes," said Dr. Pessin. "For example, we recently mapped a signaling pathway that controls energy expenditure in mice. By blocking this pathway, we can increase energy expenditure and cause weight loss in these animals. We're now trying to develop drugs that can interfere with this pathway in humans. If we're successful, we'll take our findings to clinical trials."

To support its various research efforts, Einstein's DRTC has established several research cores, which give individual investigators access to technologies, equipment, and expertise that they could not assemble on their own. There are now six research cores: animal physiology, horm
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Contact: Deirdre Branley
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

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