NIH awards $10.8M to Columbia to study connection between diabetes and hea...(osis. In addition to working with Dr. Ta...),Health

Date:9/17/2007

osis. In addition to working with Dr. Tabas on macrophage death pathways, Dr. Tall will work with Dr. Accili to investigate pathways involved in production of lipoproteins, such as very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL, often called bad cholesterol), in insulinresistant states. This will offer clues as to how high atherogenic lipoprotein levels contribute to heart disease in people with diabetes.

Dr. Domenico Accili s research is focused on the pathogenesis of insulin action and resistance and its role in type 2 diabetes. He plans to use new mouse models to investigate potentially pro-atherogenic or plaque-causing insulin actions in the liver and macrophages as part of this NIH grant. Dr. Accilis lab has recently shown that insulin action in liver, brain and beta cells is sufficient to confer insulin sensitivity onto the whole organism and protect against the development of diabetes in mice.

In addition, the lead investigators will call upon the biostatistical and mouse modeling expertise of Carrie L. Welch, Ph.D., associate research scientist, and Rajasekhar Ramakrishnan, Sc.D., research scientist and acting director of the division of biomathematics, to help with the design and analysis of mouse phenotype data and microarray experiments.

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Contact: Elizabeth Streich eas2125@columbia.edu 212-305-6535 Columbia University Medical Center Source:Eurekalert

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