Navigation Links
NIH award goes to UT MD Anderson imaging innovator Guerrero
Date:10/1/2010

HOUSTON - Digging more data out of lung CT scans to improve treatment of lung cancer and diagnosis of chronic obstructive pulmonary disease has earned a physician-scientist at The University of Texas MD Anderson Cancer Center a New Innovator Award from the National Institutes of Health.

The award, one of 52 announced Thursday out of 2,200 applications, provides $1.5 million over five years to Thomas Guerrero, M.D., Ph.D., associate professor in MD Anderson's Department of Radiation Oncology.

"We are excited about Dr. Guerrero's innovator award," said Thomas Buchholz, M.D., professor and chair of the Department of Radiation Oncology. "His work represents a novel, noninvasive imaging method for better understanding of lung function, which will enable us to further personalize radiation treatment planning to provide the most effective and safe treatment of lung cancer."

Since 2003, Guerrero and colleagues have refined a mathematical program - an algorithm - designed to more accurately identify damaged areas of the lung. Their program applies a technology called deformable image registration (DIR) to CT scans to characterize breathing function in all areas of the lung.

"Our goal for lung cancer is to reduce toxicity caused when patients receive radiotherapy, and for COPD to characterize disease. Our research methods produce images of the distribution of lung function, or lack of lung function, throughout the lung in these patients," Guerrero said.

The NIH Innovator grant will fund a clinical trial that compares the use of Guerrero's program to target radiation at lung tumors with the current standard of image-guided targeting methods based on volume avoidance techniques. Loss of lung function will be compared between the two groups of patients.

"We're going to test the ability to reduce injury to the lung from radiation therapy for patients with advanced lung cancer," Guerrero said. "In the past we've irradiated through both good and bad parts of the lung to get to the tumor. Our algorithm will permit us to irradiate only through the nonfunctioning lung, which will allow us to preserve functioning areas and reduce overall injury to the lung."

A second study will tap CT images and clinical data from a national study called COPDgene to see whether the DIR algorithm will better characterize the damage done by a specific type of COPD.

There are two manifestations of COPD. Emphysema can be assessed with current imaging and analysis methods. "The other is small airway disease where a thickening of the walls in small airways causes air trapping. Lungs appear normal, but air is not ventilating regions beyond where airway narrowing occur. We expect to be able to identify the distribution of air trapping with this method."

The COPD research involves applying the algorithm to two separate CT images of a patient's lung, one captured when a patient holds a breath at inhalation and the other at exhalation. The program then couples information from the two images to create a detailed picture of lung function.

The lung cancer study applies the algorithm to four-dimensional CT imaging, which produces 10 images of a single breath.

"The ultimate goal is to develop software that can be incorporated into existing medical computer work stations for CT analysis and for radiation treatment planning in every hospital, large and small, in the country," Guerrero said.

Guerrero is the second NIH Innovator Award winner from MD Anderson. Gabor Balazsi, Ph.D., an assistant professor in MD Anderson's Department of Systems Biology, won one last year.

"NIH is pleased to be supporting early-stage investigators from across the country who are taking considered risks in a wide range of areas in order to accelerate research," said Francis S. Collins, M.D., Ph.D., director of the National Institutes of Health. "We look forward to the results of their work."

Guerrero has been at MD Anderson for 8 years. He earned his doctorate at UCLA under the direction of Edward J. Hoffman, Ph.D., co-inventor of Positron Emission Tomography. One of his graduate course projects led to the development of whole-body PET imaging.

He has been elected a top 10 researcher in cancer imaging twice by the readers of Medical Imaging magazine and holds an adjunct associate professorship in computational and applied mathematics at Rice University.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Mental Health America Encourages Journalists, Media Professionals to Submit Entries for 2010 Media Awards
2. 2010 HSR Impact Award recognizes surgical safety research
3. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
4. International Diabetes Federation awards $2 million to 9 global diabetes research projects
5. Highmark Foundation Awards $120,000 to the American Heart Association
6. Rocketboy Media Wins Award for Masonic Lodge Web Site; Announces Signing of Several New Clients
7. Multi-Award Winning Author Tina Turbin Interviews Special Guest Dr. Peter H.R. Green, M.D. On The Thrive in Balance Radio Show
8. Gladstones Robert Mahley to receive Research!America advocacy award
9. Republicans Give Top Award to Betsy McCaughey, Healthcare Patriot, & Rev Up for Upcoming Elections
10. Diane von Furstenberg Establishes The DVF Awards to Recognize Outstanding Women Leaders
11. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH award goes to UT MD Anderson imaging innovator Guerrero
(Date:4/25/2017)... ... 25, 2017 , ... The doctors at Wall Centre Dental are now expanding ... and require sedation to receive dental care. The doctors offer three treatment options to ... cleanings to oral surgery, at their dental office in Vancouver. Wall Centre Dental is ...
(Date:4/25/2017)... ... April 25, 2017 , ... Patients ... that achieves results in a fraction of the time as traditional braces – ... Significance Dental Specialists, now offers this revolutionary treatment with or without a referral. ...
(Date:4/25/2017)... ... April 25, 2017 , ... As Spring reignites vigilance ... research related to Zika virus during pregnancy, as well as other prenatal exposures ... science. , The Teratology Society is an international and multidisciplinary ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... Buyers and ... recreational users to dispensaries and head shops –can’t help but be heartened by the ... the tell-tale cannabis odor aptly described as “skunk smell.” At last they can ...
(Date:4/25/2017)... Clara, CA (PRWEB) , ... April 25, 2017 ... ... announces the addition of predictive analytics to its patient care management module. Using ... compliance even before a patient has been initiated on continuous positive airway pressure ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017  Cardinal Health (NYSE: ... 1 fiscal 2017 earnings per share (EPS) guidance ... 2019.  This is in conjunction with this morning,s announcement ... Vein Thrombosis and Nutritional Insufficiency businesses. Cardinal ... continuing operations will be at the bottom of its ...
(Date:4/18/2017)... , April 18, 2017 Viverae ® , ... announce the integration of IBM ® Watson Campaign ... deliver targeted communications for a personalized experience. Through digital ... on their health in real time. The enhanced experience ... most to members, wherever they are in their journey ...
(Date:4/18/2017)... -- Astute Medical, Inc., developer of biomarkers for better healthcare, ... the 2017 National Kidney Foundation (NKF) Spring Clinical ... 22. Physicians will present data on two biomarkers, ... acute kidney injury (AKI) during the management of patients ... Elevated levels of TIMP-2 and IGFBP-7 have been shown ...
Breaking Medicine Technology: