Navigation Links
NIH award goes to UT MD Anderson imaging innovator Guerrero
Date:10/1/2010

HOUSTON - Digging more data out of lung CT scans to improve treatment of lung cancer and diagnosis of chronic obstructive pulmonary disease has earned a physician-scientist at The University of Texas MD Anderson Cancer Center a New Innovator Award from the National Institutes of Health.

The award, one of 52 announced Thursday out of 2,200 applications, provides $1.5 million over five years to Thomas Guerrero, M.D., Ph.D., associate professor in MD Anderson's Department of Radiation Oncology.

"We are excited about Dr. Guerrero's innovator award," said Thomas Buchholz, M.D., professor and chair of the Department of Radiation Oncology. "His work represents a novel, noninvasive imaging method for better understanding of lung function, which will enable us to further personalize radiation treatment planning to provide the most effective and safe treatment of lung cancer."

Since 2003, Guerrero and colleagues have refined a mathematical program - an algorithm - designed to more accurately identify damaged areas of the lung. Their program applies a technology called deformable image registration (DIR) to CT scans to characterize breathing function in all areas of the lung.

"Our goal for lung cancer is to reduce toxicity caused when patients receive radiotherapy, and for COPD to characterize disease. Our research methods produce images of the distribution of lung function, or lack of lung function, throughout the lung in these patients," Guerrero said.

The NIH Innovator grant will fund a clinical trial that compares the use of Guerrero's program to target radiation at lung tumors with the current standard of image-guided targeting methods based on volume avoidance techniques. Loss of lung function will be compared between the two groups of patients.

"We're going to test the ability to reduce injury to the lung from radiation therapy for patients with advanced lung cancer," Guerrero said. "In the past we've irradiated through both good and bad parts of the lung to get to the tumor. Our algorithm will permit us to irradiate only through the nonfunctioning lung, which will allow us to preserve functioning areas and reduce overall injury to the lung."

A second study will tap CT images and clinical data from a national study called COPDgene to see whether the DIR algorithm will better characterize the damage done by a specific type of COPD.

There are two manifestations of COPD. Emphysema can be assessed with current imaging and analysis methods. "The other is small airway disease where a thickening of the walls in small airways causes air trapping. Lungs appear normal, but air is not ventilating regions beyond where airway narrowing occur. We expect to be able to identify the distribution of air trapping with this method."

The COPD research involves applying the algorithm to two separate CT images of a patient's lung, one captured when a patient holds a breath at inhalation and the other at exhalation. The program then couples information from the two images to create a detailed picture of lung function.

The lung cancer study applies the algorithm to four-dimensional CT imaging, which produces 10 images of a single breath.

"The ultimate goal is to develop software that can be incorporated into existing medical computer work stations for CT analysis and for radiation treatment planning in every hospital, large and small, in the country," Guerrero said.

Guerrero is the second NIH Innovator Award winner from MD Anderson. Gabor Balazsi, Ph.D., an assistant professor in MD Anderson's Department of Systems Biology, won one last year.

"NIH is pleased to be supporting early-stage investigators from across the country who are taking considered risks in a wide range of areas in order to accelerate research," said Francis S. Collins, M.D., Ph.D., director of the National Institutes of Health. "We look forward to the results of their work."

Guerrero has been at MD Anderson for 8 years. He earned his doctorate at UCLA under the direction of Edward J. Hoffman, Ph.D., co-inventor of Positron Emission Tomography. One of his graduate course projects led to the development of whole-body PET imaging.

He has been elected a top 10 researcher in cancer imaging twice by the readers of Medical Imaging magazine and holds an adjunct associate professorship in computational and applied mathematics at Rice University.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

Related medicine news :

1. Mental Health America Encourages Journalists, Media Professionals to Submit Entries for 2010 Media Awards
2. 2010 HSR Impact Award recognizes surgical safety research
3. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
4. International Diabetes Federation awards $2 million to 9 global diabetes research projects
5. Highmark Foundation Awards $120,000 to the American Heart Association
6. Rocketboy Media Wins Award for Masonic Lodge Web Site; Announces Signing of Several New Clients
7. Multi-Award Winning Author Tina Turbin Interviews Special Guest Dr. Peter H.R. Green, M.D. On The Thrive in Balance Radio Show
8. Gladstones Robert Mahley to receive Research!America advocacy award
9. Republicans Give Top Award to Betsy McCaughey, Healthcare Patriot, & Rev Up for Upcoming Elections
10. Diane von Furstenberg Establishes The DVF Awards to Recognize Outstanding Women Leaders
11. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH award goes to UT MD Anderson imaging innovator Guerrero
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing skills ... patients and their families pay tribute to a genetic counselor by nominating him or ... Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome magazine ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Venture ... Golf Classic Tournament held on June 20th at the Woodmont Country Club at ... Luke’s Wings, an organization dedicated to helping service members that have been wounded in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Market - Forecast to 2022" report to their offering. ... method for the patients with kidney failure, it replaces the ... from the patient,s blood and thus the treatment helps to ... chloride in balance. Increasing number of ESRD ...
Breaking Medicine Technology: