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NIH Grant to support Mount Sinai Research Program to Create Biological Network Model of Alzheimer’s Disease in partnership with New York Stem Cell Foundation
Date:9/18/2013

l cellular and animal models to validate the actions of individual genes, as well as entire molecular networks predicted to drive the disease. The team will also employ a computational approach to test if any existing drugs currently used for other conditions are capable of modulating the Alzheimer’s networks and can, therefore, be repurposed for Alzheimer’s disease treatment or prevention.

This award was among several new research grants totaling $45 million NIH announced on Wednesday to advance the National Plan to Address Alzheimer’s Disease, a national effort that aims to find effective interventions for Alzheimer’s by 2025. Dr. Neil Buckholtz, Director of the Division of Neuroscience at the National Institute on Aging, which leads the NIH Alzheimer’s research program, noted that the array of grants will fund innovative basic research as well as new clinical trials aimed at finding therapies to prevent the disorder. “We are delighted to support Dr. Schadt and his team in their important work of applying novel analytical methods to build models of this complex disorder,” Buckholtz said. “Additionally, this funding supports their computational approach investigating the repurposing of existing drugs as treatment for Alzheimer’s-- a key objective set forth in the Alzheimer’s Plan.”

Scott Noggle, PhD, Director of the NYSCF Laboratory and the NYSCF – Charles Evans Senior Research Fellow for Alzheimer’s Disease, is a principal investigator in the study. Dr. Noggle and his team at NYSCF will be the lead stem cell partner in this study. They will generate stem cell lines from Alzheimer’s patient samples and produce Alzheimer’s neurons that will be used as a platform for validating drug targets that are identified through computational analysis. Stem cell lines and neurons will be produced on the unique NYSCF Global Stem Cell ArrayTM, a proprietary automated technology platform that for the first time makes it possible to create identical stem cell
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