Navigation Links
NIH, Gates Foundation and Colorado State team up to find new approach to a TB vaccine
Date:1/25/2011

WHAT: A team of U.S. and European researchers have found that a new vaccine strategy tested in mice provides stronger, more long-lasting protection from tuberculosis (TB) infection than the vaccine currently used in humans, known as BCG. Their findings were published online on January 23rd in the journal Nature Medicine.

The study was co-funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the Bill & Melinda Gates Foundation. It was coordinated by the NIAID-funded TB Vaccine Testing and Research Materials program at Colorado State University, an initiative to speed the development of new TB vaccines and treatments.

Caused by the bacterium Mycobacterium tuberculosis (Mtb), TB remains one of the major causes of disability and death worldwide, with an estimated 1.7 million deaths in 2009 and increasing rates of drug-resistant disease. The BCG vaccine, the only one approved for human use, provides some protection against initial TB illness but does not prevent latent infection, in which Mtb persists in human cells for years and may later develop into active disease.

In this study, the researchers combined two proteins previously found to improve the BCG vaccine's effectiveness with a new component, a stress response protein that mice produce throughout the TB infection process. This three-component vaccine, known as H56, was administered to uninfected mice before and after BCG vaccination. Six weeks later, the mice were exposed to Mtb. The multistage strategy not only protected against initial illness, but controlled reactivation of latent infection and reduced Mtb levels in the lungs more effectively than BCG alone. Because of the success of this study, the vaccine candidate is now entering clinical development.


'/>"/>

Contact: Nalini Padmanabhan
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
2. Bill & Melinda Gates, Asian Parliamentary Group, Win 2010 United Nations Population Award
3. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
4. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
5. Food Safety Law Firm Investigates Major Outbreak of E. coli Linked To Lettuce
6. Georgia Tech awarded Gates Foundation grant for innovative global health research
7. Drug mitigates toxic effects of radiation in mice
8. AIDS 2010 delegates and speakers unite in support of full funding for the Global Fund, the next milestone in drive for universal access
9. Thesis investigates characteristics of society using sports activities as research tool
10. UI study investigates variability in mens recall of sexual cues
11. BUSM investigates cellular mechanisms leading to immune response in airway epithelium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... 31, 2015 , ... There’s no better way to enjoy the summer weather ... cook the next meal, making July the most appropriate to be National Hot Dog ... recipes. , Make the next cookout different than the ones in the past. Celebrate ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... communicate. Rally Insurance Group, Inc. has re-branded their social media profiles to better ... personal way for consumers to communicate, find information, share insights and opinions. The ...
(Date:7/31/2015)... ... 2015 , ... M3 USA MDLinx.com, source of the Smartest Doc Board Exam ... , The additions of Gastroenterology, Pulmonology and Allergy/Immunology round out an already robust ... the exam easy and painless. MDLinx offers thousands of board-exam style questions and ...
(Date:7/31/2015)... ... ... According to the article published July 27 on My News LA, a fire ... by the city’s fire department before it caused major damage throughout the building. The article ... and it was a fire alarm system that tipped off fire fighters so they could ...
(Date:7/31/2015)... Las Vegas, NV (PRWEB) , ... July 31, 2015 , ... ... Vegas bakery is now offering wedding cakes with custom designs, making life ... hard to deliver beautifully designed wedding cakes for each customer who orders one. , ...
Breaking Medicine News(10 mins):Health News:King Kullen Honors National Hot Dog and Blueberry Month 2Health News:King Kullen Honors National Hot Dog and Blueberry Month 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 2Health News:MDLinx Offers Three New Board Exam Prep Courses - Gastroenterology, Pulmonology and Allergy/Immunology 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2
... Marsha Parsons bring you a best-selling competency-based training ... quality of care provided to people with intellectual ... (PBSTC) teaches direct support staff and supervisors the ... to people with intellectual and developmental disabilities. , ...
... of Health Care Costs in the U.S. , , ... Obama was clear in his vision, forceful in his intent, but ... health care reform. In making his case to the American public ... is critical to solving the problem -- and that driver is ...
... segments of the population during a natural disaster," said Bill Numbers, ... and Response at Fresenius Medical Care North America (FMCNA). , ... ... represent one of the most at risk segments of the population ...
... Challenged Students to Submit Thoughts About Healthy LivingWEST NEW ... and Union City Board of Education announced the winners ... special luncheon at The Lighthouse Restaurant in West New ... poems or rap lyrics that best communicate their understanding ...
... Program Allows Doctors to Diagnose and Advise Patients ... A telemedicine program for researchers and ... week as the GW Medical Faculty Associates -- ... George Washington University -- completed the ...
... The American Academy ... announced today its support of efforts to address the nation,s long-term ... reform the U.S. health care system and restore retirement security for ... to be a top priority regardless of any other actions taken ...
Cached Medicine News:Health News:Positive behavior support training curriculum 2Health News:Partnership Applauds President for Shining Light on True Cost Driver in Health Care - Calls on CBO to Join the Effort 2Health News:Preparing for the Next Disaster: Dialysis Community Briefs Hill About Emergency Response 2Health News:Preparing for the Next Disaster: Dialysis Community Briefs Hill About Emergency Response 3Health News:Preparing for the Next Disaster: Dialysis Community Briefs Hill About Emergency Response 4Health News:AMERIGROUP Foundation and Union City Board of Education Announce Winners of 'Word About Health' Contest 2Health News:Remote Medicine: GWU Medical Faculty Treat Antarctica Personnel 2Health News:Actuaries: Priority on Health Reform and Retirement Security Signals Tough Choices Ahead 2Health News:Actuaries: Priority on Health Reform and Retirement Security Signals Tough Choices Ahead 3
(Date:7/30/2015)... 2015  Growth of the U.S. nonprescription market is ... prescription users to the OTC market. Due to an ... Rx-to-OTC switch activity over the next five years with ... new brands entering the market into existing categories. ... years (even those with low to moderate likelihood), the ...
(Date:7/30/2015)... NEW YORK , July 30, 2015 ... releases a new research report with market ... size, share, forecast, porter analysis, recent developments, ... Global Industry Insight: Biosensors Market ...      (Logo: http://photos.prnewswire.com/prnh/20150727/756778 ) ...
(Date:7/30/2015)... July 30, 2015 Takeda Pharmaceutical Company ... to fulfill the post-marketing commitment and submissions of ... European Multi-Database Bladder Cancer Risk Characterization Study , ... study, conducted in four European countries, for pioglitazone ... to 10 years of follow-up. Findings demonstrate that ...
Breaking Medicine Technology:Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 2Rx-to-OTC Switches -- Game Changers for the U.S. OTC Drugs Market through 2019, Sees Kline 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 2Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 3Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 4Global Biosensors Market (Size of $12,964 Million in 2014) to Witness 10% CAGR During 2015 - 2020 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 2Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 6
... Study Uncovers How Each Tooth Signals the Next to ... opposing genetic forces determines why mammals develop a single ... a study published today in the journal Science. When ... may help guide efforts to re-grow missing teeth and ...
... key steps to preventing bone loss focus on early ... osteoporosis are staggering. 75 million baby boomers are approaching ... on their bones. Osteoporosis ( http://orthoinfo.aaos.org/topic.cfm?topic=A00232 ... fractures in the United States annually. According to ...
Cached Medicine Technology:Scientists Discover Why Teeth Form in a Single Row 2Scientists Discover Why Teeth Form in a Single Row 3Scientists Discover Why Teeth Form in a Single Row 4Scientists Discover Why Teeth Form in a Single Row 5Staying One Step Ahead of Osteoporosis 2Staying One Step Ahead of Osteoporosis 3Staying One Step Ahead of Osteoporosis 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: