Navigation Links
NIH, Gates Foundation and Colorado State team up to find new approach to a TB vaccine
Date:1/25/2011

WHAT: A team of U.S. and European researchers have found that a new vaccine strategy tested in mice provides stronger, more long-lasting protection from tuberculosis (TB) infection than the vaccine currently used in humans, known as BCG. Their findings were published online on January 23rd in the journal Nature Medicine.

The study was co-funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the Bill & Melinda Gates Foundation. It was coordinated by the NIAID-funded TB Vaccine Testing and Research Materials program at Colorado State University, an initiative to speed the development of new TB vaccines and treatments.

Caused by the bacterium Mycobacterium tuberculosis (Mtb), TB remains one of the major causes of disability and death worldwide, with an estimated 1.7 million deaths in 2009 and increasing rates of drug-resistant disease. The BCG vaccine, the only one approved for human use, provides some protection against initial TB illness but does not prevent latent infection, in which Mtb persists in human cells for years and may later develop into active disease.

In this study, the researchers combined two proteins previously found to improve the BCG vaccine's effectiveness with a new component, a stress response protein that mice produce throughout the TB infection process. This three-component vaccine, known as H56, was administered to uninfected mice before and after BCG vaccination. Six weeks later, the mice were exposed to Mtb. The multistage strategy not only protected against initial illness, but controlled reactivation of latent infection and reduced Mtb levels in the lungs more effectively than BCG alone. Because of the success of this study, the vaccine candidate is now entering clinical development.


'/>"/>

Contact: Nalini Padmanabhan
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
2. Bill & Melinda Gates, Asian Parliamentary Group, Win 2010 United Nations Population Award
3. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
4. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
5. Food Safety Law Firm Investigates Major Outbreak of E. coli Linked To Lettuce
6. Georgia Tech awarded Gates Foundation grant for innovative global health research
7. Drug mitigates toxic effects of radiation in mice
8. AIDS 2010 delegates and speakers unite in support of full funding for the Global Fund, the next milestone in drive for universal access
9. Thesis investigates characteristics of society using sports activities as research tool
10. UI study investigates variability in mens recall of sexual cues
11. BUSM investigates cellular mechanisms leading to immune response in airway epithelium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... July 07, 2015 , ... Quadrino Law Group is pleased to announce the ... York 11747. The new facility is a state of the art building, located ... Quadrino, the firm's CEO and founder, said, "We are pleased to service our clients ...
(Date:7/7/2015)... ... , ... SC&H Group, a leading audit, tax, and consulting firm, recently hosted ... through company-wide volunteering efforts. , On an annual basis, in coordination with Business ... need throughout Baltimore and Washington D.C. , This year, SC&H Group’s team ...
(Date:7/7/2015)... ... 2015 , ... At the end of June Pacific Prime Renewals team in Hong Kong ... spearheaded by the Renewals Manager, Danielle Cotton, aims to not only reduce but eventually eliminate ... Cotton explained, “We send anything between 300 and 600 pieces of paper per month. Not ...
(Date:7/7/2015)... ... July 07, 2015 , ... Summer is a great time to get ... Insurance is sharing some safety tips. , Jean Tapley, senior wellness coordinator at Amica, ... , Start slowly. Going from no activity to several hours ...
(Date:7/7/2015)... ... July 07, 2015 , ... Healthpointe is proud to announce the ... anesthesiologist and pain management specialist, will be evaluating and treating patients with orthopedic complaints, ... After receiving his Bachelor of Science in Biology from the University of the East, ...
Breaking Medicine News(10 mins):Health News:SC&H Group Celebrates 9th Annual Day of Service 2Health News:Pacific Prime Hong Kong Renewals Team Starts Push to go Green 2Health News:Amica Insurance Has 7 Summer Safety Tips 2Health News:Dr. Pedro S. Alupay, M.D., Now Providing Pain Management Services at Healthpointe in Irwindale 2Health News:Dr. Pedro S. Alupay, M.D., Now Providing Pain Management Services at Healthpointe in Irwindale 3
... May 9 , WHAT: Passport Health, nationwide ... anyone traveling to Myanmar to,assist with recovery efforts ... areas and there is no fresh water or ... delta are crammed with dead bodies,and animal carcasses. ...
... with the 2008 CVS ... Women,s Health Award, WOONSOCKET, R.I., May 9 In recognition ... has,named Dr. Marianne Legato and Dr. Roseanna Means as recipients of ... recognized,last evening at an event in New York City. The awards ...
... first international relief groups to reach,stricken Myanmar, ... waited for access to cyclone ravaged Myanmar, among ... was Shelterbox, a grassroots,disaster relief organization supported by ... trained team of volunteers was on the ground ...
... Washington University School of Medicine in St. Louis working ... immune cells long thought to be responsible for type ... the immune cells from isolated insulin-making structures in the ... the immune cells, known as dendritic cells, "red-handed": carrying ...
... May 9 The number of U.S. hospitals ... from over 7,000 in 1975 to 5,747 in,2007. ... increases in medical errors, and rising administrative,and energy ... processes and reduce costs, hospitals are increasingly turning,to ...
... for world,s largest surgical,organization, WASHINGTON, May 9 ... a new home for its Washington, D.C.,office that will ... class A office building, located at 20 F Street, ... ACS headquarters will remain in its,current location in Chicago., ...
Cached Medicine News:Health News:Passport Health Disaster Response Experts Offer Services to Myanmar Volunteers 2Health News:CVS Caremark Honors Heroes in Women's Health 2Health News:CVS Caremark Honors Heroes in Women's Health 3Health News:Rotary Clubs Provide Emergency Shelters, Supplies to Cyclone Victims 2Health News:Suspected cause of type 1 diabetes caught 'red-handed' for the first time 2Health News:Suspected cause of type 1 diabetes caught 'red-handed' for the first time 3Health News:Can Wireless Technologies Rescue U.S. Hospitals? 2Health News:American College of Surgeons Breaks Ground on New Office Building on Capitol Hill 2
(Date:7/7/2015)... Research and Markets( http://www.researchandmarkets.com/research/hmdflj/outlook_of_global ... of Global Biologic Drug Discovery Outsourcing Market" report ... discovery outsourcing market will likely grow in a CAGR ... $11.4 B by 2020. It has been ... become a new but important type of medication. They ...
(Date:7/7/2015)... -- Dedicated to promoting wellness and giving back to its ... purple pledge in support of Alzheimer,s & Brain-Awareness Month. ... time to shine a purple light for the millions ... in our community who are affected by Alzheimer,s. Raising ... helps mobilize friends, family members, neighbors and coworkers to ...
(Date:7/7/2015)... , July 7, 2015 The ... USD 1,197.7 million by 2020, growing at an estimated CAGR ... study by Grand View Research, Inc. Introduction of innovative technologies ... with growing awareness levels pertaining to the advantages of breast ... next six years. In addition, presence of untapped growth opportunities ...
Breaking Medicine Technology:Outlook of Global Biologic Drug Discovery Outsourcing Market to 2020 2Outlook of Global Biologic Drug Discovery Outsourcing Market to 2020 3Purple for a Purpose: Supporting Alzheimer's & Brain-Awareness Month 2Breast Pumps Market To Reach $1,197.7 Million By 2020: Grand View Research, Inc. 2Breast Pumps Market To Reach $1,197.7 Million By 2020: Grand View Research, Inc. 3Breast Pumps Market To Reach $1,197.7 Million By 2020: Grand View Research, Inc. 4
A single tube that performs two rapid tests for E. coli from culture. ColiScreen™ combines both the indole test with the glucuronidase test to increase the specificity....
Legionella provides rapid, accurate results that aid in the presumptive diagnosis of Legionella infection (Legionnaires' Disease)....
... The Trinity Biotech Captia™ ... Assay (ELISA) is intended for ... antibodies (IgG and IgM) to ... in serum from patients with ...
The GoodKnight® 425 Bi-Level® device is suitable for travel and includes features such as automatic altitude compensation, optional cigarette lighter adapter and portable battery pack...
Medicine Products: