Navigation Links
NIH, Gates Foundation and Colorado State team up to find new approach to a TB vaccine
Date:1/25/2011

WHAT: A team of U.S. and European researchers have found that a new vaccine strategy tested in mice provides stronger, more long-lasting protection from tuberculosis (TB) infection than the vaccine currently used in humans, known as BCG. Their findings were published online on January 23rd in the journal Nature Medicine.

The study was co-funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and the Bill & Melinda Gates Foundation. It was coordinated by the NIAID-funded TB Vaccine Testing and Research Materials program at Colorado State University, an initiative to speed the development of new TB vaccines and treatments.

Caused by the bacterium Mycobacterium tuberculosis (Mtb), TB remains one of the major causes of disability and death worldwide, with an estimated 1.7 million deaths in 2009 and increasing rates of drug-resistant disease. The BCG vaccine, the only one approved for human use, provides some protection against initial TB illness but does not prevent latent infection, in which Mtb persists in human cells for years and may later develop into active disease.

In this study, the researchers combined two proteins previously found to improve the BCG vaccine's effectiveness with a new component, a stress response protein that mice produce throughout the TB infection process. This three-component vaccine, known as H56, was administered to uninfected mice before and after BCG vaccination. Six weeks later, the mice were exposed to Mtb. The multistage strategy not only protected against initial illness, but controlled reactivation of latent infection and reduced Mtb levels in the lungs more effectively than BCG alone. Because of the success of this study, the vaccine candidate is now entering clinical development.


'/>"/>

Contact: Nalini Padmanabhan
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
2. Bill & Melinda Gates, Asian Parliamentary Group, Win 2010 United Nations Population Award
3. Long Island Press Investigates Big Tobacco's Lobby to Kill Indian Cigarette Trade
4. SC Johnson and Bill & Melinda Gates Foundation Unite to Combat Malaria
5. Food Safety Law Firm Investigates Major Outbreak of E. coli Linked To Lettuce
6. Georgia Tech awarded Gates Foundation grant for innovative global health research
7. Drug mitigates toxic effects of radiation in mice
8. AIDS 2010 delegates and speakers unite in support of full funding for the Global Fund, the next milestone in drive for universal access
9. Thesis investigates characteristics of society using sports activities as research tool
10. UI study investigates variability in mens recall of sexual cues
11. BUSM investigates cellular mechanisms leading to immune response in airway epithelium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2017)... ... 2017 , ... The JPR Group, a public relations and ... will be assisting HackensackUMC Mountainside with its public relations efforts, effective January 2017. ... towns. The firm will be working closely with HackensackUMC Mountainside’s internal marketing operations. ...
(Date:1/14/2017)... ... January 14, 2017 , ... AgileMinder develops innovative products ... The Emoji Scale is now available on Apple as a fun, free emoji sticker ... by choosing one of the ten color coded values on The Emoji Scale. ...
(Date:1/13/2017)... Madrid, Spain (PRWEB) , ... January 13, 2017 , ... ... the Melia Avenida America hotel on March 3-4, 2017. This Congress is expertly ... focused on the management of patients with lung cancer. , Chaired by Dr. Giorgio ...
(Date:1/13/2017)... ... January 13, 2017 , ... ... has taken on the challenge of providing additional organic alternatives for customers who ... launch of the brand’s new line of all-natural activated charcoal products, Moody Zook ...
(Date:1/13/2017)... ... , ... People who have sensitive teeth are about as common as those ... Sadly, most dental hygiene products in the market contain chemical ingredients that only aggravate ... their daily oral care routine to keep their teeth white and healthy is a ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... , January 16, 2017 Bill is ... number of general management and leadership positions with global medical device ... a strong track record of launching new products and building successful ... , Africa and North ... ...
(Date:1/16/2017)... -- Cumberland Pharmaceuticals Inc. (NASDAQ: CPIX) is pleased to announce ... to its Board of Directors. He is the President ... LLC . He is also the Chief Investment Officer ... firm with over $1.5 billion under management. ... analysis and portfolio management. He began his career in ...
(Date:1/15/2017)... , Jan. 14, 2017 ImmersiveTouch Inc., ... for surgeons, today announced recent appointments strengthening their Executive ... James Bowman as Chief Executive Officer, Jay ... as Vice President of Sales and Jia ... Mr. Bowman has 20 ...
Breaking Medicine Technology: