Navigation Links
NIAID to fund new human immune profiling research centers
Date:8/24/2009

The National Institute of Allergy and Infectious Diseases (NIAID), a component of the National Institutes of Health, is accepting grant applications for a new initiative to establish a consortium of human immune profiling research centers. The purpose of these cooperative centerswhich together will receive funding up to $100 million over five yearsis to characterize the human immune system under normal conditions and to understand how it changes following infection or vaccination.

NIAID will launch this new research initiative in 2010, with the funding for the first year of the initiative coming from the American Recovery and Reinvestment Act.

"By helping us understand what constitutes a normal human immune response, this program will assist researchers who are developing vaccines and other interventions for a variety of infectious diseases of public health importance, including influenza, malaria, tuberculosis and HIV/AIDS," says NIAID Director Anthony S. Fauci, M.D.

Researchers will examine various elements of the immune systemincluding white blood cell subsets, signaling molecules and antibodiesafter exposure to either infectious agents such as viruses or bacteria or to the components of a vaccine, including vaccine boosters known as adjuvants. They also will follow immune responses as they return to a resting state. By doing so, immunologists can identify specific patterns of the various subsets of white blood cells and immune molecules that reflect the status and function of the immune system under different conditions.

A significant challenge for immunologists is to understand how the immune system behaves at rest, also known as homeostasis. A state of immunological homeostasis does not reflect a lack of immunologic activity, or even a restful condition. Furthermore, the immune system of an individual may return to one of several homeostatic states, depending on the nature of the particular immune challenge, such as infection or vaccination.

Although studies in mice have helped advance the understanding of immunological mechanisms, they have several limitations, and findings in animals cannot always be extrapolated to humans. In the new initiative, researchers will analyze samples from well-characterized human cohorts, such as people enrolled in clinical trials, children receiving routine vaccinations, and people with naturally acquired infections. These cohorts will represent the diversity of human populations with respect to genetics, age, ethnicity and gender.

The new program will exploit research approaches that have only recently become available such as systems biology, which integrates information about an organism's genes, proteins and metabolism with data from the host.

In addition, the initiative will provide support for centralized infrastructure to collect, characterize, and store the human samples; for bioinformatic capacity to analyze the large and complex data sets that will be generated; and for the discovery and development of new immune response monitoring tools and sample-sparing assays.

"The observations made and the new methodologies developed by investigators within this program will assist clinical research in vaccine development and beyond," says Daniel Rotrosen, M.D., director of the Division of Allergy, Immunology and Transplantation at NIAID. "These research centers are part of NIAID's long-range goal to identify the principles of human immune regulation, and then apply that knowledge to understanding, treating and preventing immune-mediated and infectious diseases."


'/>"/>

Contact: Julie Wu
wujuli@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIAID media availability: Still searching for predictors of asthma attacks
2. NIAID set to launch clinical trials to test 2009 H1N1 influenza vaccine candidates
3. NIAID media availability: New strategy proposed for designing antibody-based HIV vaccine
4. J. Craig Venter Institute Awarded $43 Million, Five Year Contract From NIAID to Continue to Develop and Provide Sequencing, Genotyping, and Bioinformatics Expertise and Services in Infectious Diseases
5. NIAID and Chinese officials sign agreement to foster TB research in Chinas Henan province
6. NIAID honors AIDS activist Martin Delaney
7. NIAID media availability: Seizures following parasitic infection associated with brain swelling
8. NIAID awards contracts to search for protein markers of disease
9. NIAID creates HIV vaccine discovery branch
10. NIAID to advance B-cell approach to HIV vaccines
11. NIAID describes research priorities to fight drug-resistant tuberculosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 26, 2016 , ... On May 23rd during the National Eye Institute’s “Healthy ... water advocate, was honored by Ashram, Inc. as the world’s foremost water visionary. , ... the banks of the Nile to fill their red clay pots with life-sustaining water.” ...
(Date:5/26/2016)... , ... May 26, 2016 , ... The introduction of ... ADDING PROTECTION TO YOUR HEAD ™”. , “We are proud to introduce ... the football front we have Brian Quick, wide receiver for Los Angeles who was ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... . With over 20 years of experience in leading technology and human resources ... years of university teaching, Morrow-Fox will be featured on Metcalf’s VoiceAmerica radio ...
(Date:5/26/2016)... ... , ... May 2016 – Lips may be a central feature on our ... numbers of clients now ask about lip plumping and primping techniques and want tips ... Advanced Dermatology P.C. , The trend is a national one, with 2.4 ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... is happy to announce the launch of its brand equity product, Brandvantage. ... to reflect the dynamic landscape of modern consumer decision-making. The proprietary framework ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... -- Joe Marziani has joined VMS BioMarketing as senior vice president of sales, announced ... role, Marziani will lead the company,s business development and sales team, exploring new opportunities ... Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... 24, 2016 ... , la première endoprothèse à double thérapie ... l,intervention portant sur les membres inférieurs et ... OrbusNeich, entreprise mondiale spécialisée dans la fourniture ... vie, a élargi son portefeuille pour inclure ...
(Date:5/24/2016)... , May 24, 2016 Een ... verbindt, zodat zij collectief patiënten kunnen behandelen, hun kennis ... het idee achter de nieuwe en revolutionaire MDLinking App, ... de Nederlandse vaatchirurg dr. Hans Flu en oncologisch chirurg ... die inmiddels beschikbaar is, wordt op dinsdag 24 mei ...
Breaking Medicine Technology: