Navigation Links
NIAID media availability: Still searching for predictors of asthma attacks

A new study of persistent asthma in inner-city adolescents and young adults finds that an extensive set of clinical tests cannot successfully predict the future risk of asthma attacks in participants who both receive care based on current guidelines and adhere to treatment recommendations. This finding differs from previous reports suggesting that certain clinical findings and laboratory tests could help predict future asthma attacks. These earlier conclusions, however, were based on observations of patients with poorly controlled asthma who had not received care based on current guidelines.

The study was conducted by the Inner City Asthma Consortium (ICAC), a nationwide network of clinical researchers supported by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. ICAC member Rebecca Gruchalla, M.D., Ph.D., from the University of Texas Southwestern Medical Center in Dallas, led the study. Additional support for the research was provided by the NIH National Center for Research Resources.

The 46-week study included 546 adolescents and young adults (ages 12 to 20 years old) in 10 cities across the United States. At the start of the study, ICAC investigators gathered baseline data by conducting standard tests to assess asthma symptoms. An additional battery of tests evaluated lung inflammation, lung function and allergic status. The participants were then seen every 6 to 8 weeks at their respective ICAC centers, where they were they were treated for asthma based on NIH guidelines developed by the National Asthma Education and Prevention Program. During the study, the participants carefully adhered to their treatment regimens.

After the study was completed, the investigators analyzed the baseline measurements to determine if any of these assessments, alone or in combination, could predict future asthma symptoms or asthma attacks. The investigators observed no significant clinical correlations between these common laboratory test measurements and asthma exacerbations among the study participants.

This large, longitudinal study provides the most comprehensive analysis to date of a number of factors previously thought to be useful in predicting future asthma attacks. Based on a population of patients who followed their treatment and had well-controlled asthma, the results indicate clearly that there are no known common biological markers that can predict the course of the disease in such individuals. Further studies will be needed to identify possible predictive markers.


Contact: Julie Wu
NIH/National Institute of Allergy and Infectious Diseases

Related medicine news :

1. NIAID funds $51M contract to create comprehensive model of immune responses
2. NIAID strengthens and expands Vaccine and Treatment Evaluation Units
3. NIAID scientists identify new cellular receptor for HIV
4. NIAID to convene HIV Vaccine Summit
5. NIAID describes research priorities to fight drug-resistant tuberculosis
6. NIAID to advance B-cell approach to HIV vaccines
7. NIAID creates HIV vaccine discovery branch
8. NIAID awards contracts to search for protein markers of disease
9. NIAID media availability: Seizures following parasitic infection associated with brain swelling
10. NIAID honors AIDS activist Martin Delaney
11. NIAID and Chinese officials sign agreement to foster TB research in Chinas Henan province
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from reveals that behind the tendency to ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
Breaking Medicine Technology: