Navigation Links
NIAID media availability: Food allergy-related disorder linked to master allergy gene
Date:3/7/2010

WHAT: Scientists have identified a region of a human chromosome that is associated with eosinophilic esophagitis (EoE), a recently recognized allergic disease. People with EoE frequently have difficulty eating or may be allergic to one or more foods. This study further suggests that a suspected so-called master allergy gene may play a role in the development of this rare but debilitating disorder.

EoE is characterized by inflammation and accumulation of a specific type of immune cell, called an eosinophil, in the esophagus. Symptoms of EoE vary with age: In young children a major symptom is spitting up food, while in older children and adults, the condition may cause food to become stuck in the esophagus. These symptoms may improve when a person with EoE is restricted to a liquid formula diet that contains no protein allergens or is placed on a diet that lacks six highly allergenic foods (milk, soy, eggs, wheat, peanut and seafood). EoE is not the same as more common food allergies, which also have serious consequences. Little is known about what causes EoE, but the disease runs in families suggesting that specific genes may be involved.

Investigators led by Marc Rothenberg, M.D., Ph.D., at Cincinnati Children's Medical Center Hospital, and supported by the National Institute of Allergy and Infectious Diseases and the National Institute of Diabetes and Digestive and Kidney Diseases, both part of the National Institutes of Health, performed a genome-wide association analysis in children with EoE and healthy children. This type of study detects markers of genetic variation across the entire human genome and allows researchers to zero in on a region of a chromosome to identify genes that influence health and the development of disease.

In this study, the investigators identified changes in genes within a region on chromosome 5 that were highly associated with EoE. One of the genes in this region encodes a protein called thymic stromal lymphopoietin (TSLP). When the investigators measured the expression levels of this gene in children with EoE, they found it was more highly expressed than in children without the disorder. This result suggests that TSLP plays some role in EoE.

TSLP is made by epithelial cells, which line internal and external surfaces of the body. It has already been described as a master switch that may turn on other allergic diseases, such as asthma and atopic dermatitis (eczema).

Future research is needed to determine if these findings might lead to a genetic test for TSLP and whether drugs that block the production or function of TSLP might be useful in treating EoE.


'/>"/>

Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIAID media tip sheet: Annual Meeting of the American Academy of Allergy, Asthma and Immunology
2. NIAID announces new human immunology research awards to help fight emerging infectious diseases
3. NIAID announces vaccine adjuvant discovery contracts
4. Rib-X Pharmaceuticals Receives Award from NIAID to Develop Antibiotic Treatment for Gonorrhea
5. NIAID launches 2009 H1N1 influenza vaccine trial in pregnant women
6. NIAID funds clinical trials that address the problem of antimicrobial resistance
7. NIAID Awards New Grant to Expand Studies of Peregrines Anti-PS Antibodies to Treat Viral Hemorrhagic Fevers
8. NIAID to fund new human immune profiling research centers
9. NIAID media availability: Still searching for predictors of asthma attacks
10. NIAID set to launch clinical trials to test 2009 H1N1 influenza vaccine candidates
11. NIAID media availability: New strategy proposed for designing antibody-based HIV vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... ... May 23, 2017 , ... London, May 23, 2017: Walter ... earlier this month as a Guest Speaker and Contributor to a weeklong series of ... Common Purpose. , Walter Schindler and SAIL Capital have ...
(Date:5/23/2017)... ... 23, 2017 , ... Diagnotes, an Indianapolis-based digital healthcare communication ... its secure clinical communication platform. The platform allows clinicians to easily escalate their ... and urgency of a situation. , “We know from our daily lives ...
(Date:5/23/2017)... ... May 23, 2017 , ... Therachat , a smart guided journaling ... infographic on the current state of anxiety in support of National Mental Health Awareness ... in April 2017 and benchmarked general anxiety levels as well as identified the top ...
(Date:5/22/2017)... ... 22, 2017 , ... Today, Our Urgent Care celebrates the grand opening of ... cutting ceremony. Since opening over a month ago, Our Urgent Care Washington has ... The new Our Urgent Care walk-in clinic is located at 3195 Phoenix Center Dr., ...
(Date:5/22/2017)... ... May 22, 2017 , ... ... on Wellocity to empower WeightZone Factor members to track their exercise patterns, monitor ... excellent health education, all on their mobile phones. It also provides social networks ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... N.Y. , May 5, 2017  Hill-Rom Holdings, ... will add approximately 100,000 square feet to its Welch ... September 2016 its commitment to bring more than 100 ... , where Welch Allyn has maintained a significant presence ... help accommodate these new positions, a large portion of ...
(Date:5/4/2017)... May 4, 2017 Clarius Mobile Health, ... handheld ultrasound scanners this week at the American ... (ACOG) in San Diego, CA ... "Clarius is the perfect tool for clinicians to ... rate, and evaluate pregnancy-related complications like ectopic pregnancy ...
(Date:5/4/2017)... WAYNE, Pa. , May 4, 2017 /PRNewswire/ ... made from thermoplastics and other highly-engineered materials, is ... Microextrusion tubing has been developed in recent ... neurovascular interventional therapies and surgical applications. More expensive ... used to produce microextrusion tubing due to their ...
Breaking Medicine Technology: