Navigation Links
NIAID funds $51M contract to create comprehensive model of immune responses
Date:10/23/2007

A team of scientists is expanding efforts to develop a detailed picture of immune system function with a new $51 million, five-year contract from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The research builds on a project originally funded by NIAID in 2003, and will continue to be led by Richard Ulevitch, Ph.D., of The Scripps Research Institute in La Jolla, Calif. The contract will also involve scientists from the Institute for Systems Biology in Seattle; Stanford University in Palo Alto, Calif.; and the Australian National University, Canberra.

The collaborators on this project have previously made significant contributions to our understanding of innate immunity, the bodys first line of defense against infection, says NIAID Director Anthony S. Fauci, M.D. They are well-positioned to generate knowledge that will advance the development of new treatments, diagnostics and vaccines for infectious diseases that occur naturally or are deliberately introduced into a population.

According to Dr. Ulevitch, the researchers will use a systems biology approach to build a comprehensive model of the immune systems response to several disease-causing agents. Systems biology melds established life sciences with informatics, computer modeling and new techniques of gene and protein analysis to generate a wide-angle view of entire biological systems. To date, the team focused on developing an encyclopedic account of innate immunity. Now, the projects scope will broaden to encompass components of adaptive immunity, which includes antibodies and a diverse class of immune system cells called T cells. Dr. Ulevitch and his collaborators will create mutant mice and then screen them to find defects in the animals innate and adaptive immune reactions to viruses, including influenza, mousepox and mouse cytomegalovirus, and to several bacteria, including Salmonella and Listeria. Next, the group will conduct a systems-level analysis of the multiple immune system signaling pathways triggered by infection. The expanded project also will include studies aimed at determining the relevance to humans of genes and pathways discovered in mouse models.

We recognize that translating findings made with mouse models to their counterparts in the human immune system is a formidable challenge, says Dr. Ulevitch. But we have in place a multi-pronged approach that we believe will allow us to validate our mouse findings in human cells.

Finally, notes Dr. Ulevitch, the consortium will develop a Web-based data portal that will give the wider scientific community access to the data, animal models, antibodies and other scientific tools expected to be generated over the course of the contract. The scientific community at large will be able to use the Web resources without any specialized training in informatics or computational analysis, he notes.


'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. The World Bank funds private Hospital in India
2. Shortage of funds for providing AIDS drug in Africa and India
3. Shortage Of Funds In Primary Care Trust In UK
4. Stop spending on new treatments; allocate funds to improve the existing treatments.
5. More Funds Are Required For Immunisation Drive
6. UN Calls For More Funds For Earthquake Affected
7. Hospitals May Face Funds Crunch
8. Australian Health funds stand accused
9. More Funds required for Asian Countries to fight Bird Flu
10. Shortage of NHS funds: Many Couples Denied Infertility Treatment
11. UK Woman To Raise Funds For Women Welfare
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... , ... David J. Dykeman , Ginger Pigott , and ... at DeviceTalks West, Dec. 12, 2016, at the Fairmont Newport Beach in California. Greenberg ... global Life Sciences & Medical Technology Group have been featured speakers at every DeviceTalks ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... to its innovative Unified Instance Manager architecture, meeting the needs of multichannel ... version optimizes the unattended auto-dialing system without agents, Presence Robodialer, provides greater ...
(Date:12/8/2016)... ... December 08, 2016 , ... STAT courier is pleased to ... convenient service for Texas, they are expanding their presence in Dallas. One of the ... that will bring new jobs to the Dallas and Forth Worth market. STAT takes ...
(Date:12/8/2016)... ... December 08, 2016 , ... Healthcare is ... Dr. Botelho advocates for the mass media launching of story movements to highlight ... to share their unfortunate experiences; such a movement can generate the network power ...
(Date:12/8/2016)... ... 08, 2016 , ... The Dianne Michael Insurance Agency, an ... County, is embarking on a charity drive with the aim of generating support ... orphaned or neglected senior dogs in the Cincinnati region, and LuvFurMutts volunteers also ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)...   TriNetX , the health research network, ... signed a membership agreement to join the network ... cures. The TriNetX network is comprised ... globally, biopharmaceutical companies and contract research organizations (CROs) ... site selection, patient recruitment, and collaborative research across ...
(Date:12/8/2016)... 2016 True Health Diagnostics today announced ... services and management expertise to hospital systems throughout ... more doctors and patients to benefit from state-of-the-art ... Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... pressure to contain costs, have struggled to keep ...
(Date:12/8/2016)... 2016 Research and Markets has announced the ... offering. ... The global chromatography market to grow at a CAGR ... 2016-2020, has been prepared based on an in-depth market analysis with inputs ... prospects over the coming years. The report also includes a discussion of ...
Breaking Medicine Technology: