Navigation Links
NIAID funds $51M contract to create comprehensive model of immune responses
Date:10/23/2007

A team of scientists is expanding efforts to develop a detailed picture of immune system function with a new $51 million, five-year contract from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The research builds on a project originally funded by NIAID in 2003, and will continue to be led by Richard Ulevitch, Ph.D., of The Scripps Research Institute in La Jolla, Calif. The contract will also involve scientists from the Institute for Systems Biology in Seattle; Stanford University in Palo Alto, Calif.; and the Australian National University, Canberra.

The collaborators on this project have previously made significant contributions to our understanding of innate immunity, the bodys first line of defense against infection, says NIAID Director Anthony S. Fauci, M.D. They are well-positioned to generate knowledge that will advance the development of new treatments, diagnostics and vaccines for infectious diseases that occur naturally or are deliberately introduced into a population.

According to Dr. Ulevitch, the researchers will use a systems biology approach to build a comprehensive model of the immune systems response to several disease-causing agents. Systems biology melds established life sciences with informatics, computer modeling and new techniques of gene and protein analysis to generate a wide-angle view of entire biological systems. To date, the team focused on developing an encyclopedic account of innate immunity. Now, the projects scope will broaden to encompass components of adaptive immunity, which includes antibodies and a diverse class of immune system cells called T cells. Dr. Ulevitch and his collaborators will create mutant mice and then screen them to find defects in the animals innate and adaptive immune reactions to viruses, including influenza, mousepox and mouse cytomegalovirus, and to several bacteria, including Salmonella and Listeria. Next, the group will conduct a systems-level analysis of the multiple immune system signaling pathways triggered by infection. The expanded project also will include studies aimed at determining the relevance to humans of genes and pathways discovered in mouse models.

We recognize that translating findings made with mouse models to their counterparts in the human immune system is a formidable challenge, says Dr. Ulevitch. But we have in place a multi-pronged approach that we believe will allow us to validate our mouse findings in human cells.

Finally, notes Dr. Ulevitch, the consortium will develop a Web-based data portal that will give the wider scientific community access to the data, animal models, antibodies and other scientific tools expected to be generated over the course of the contract. The scientific community at large will be able to use the Web resources without any specialized training in informatics or computational analysis, he notes.


'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. The World Bank funds private Hospital in India
2. Shortage of funds for providing AIDS drug in Africa and India
3. Shortage Of Funds In Primary Care Trust In UK
4. Stop spending on new treatments; allocate funds to improve the existing treatments.
5. More Funds Are Required For Immunisation Drive
6. UN Calls For More Funds For Earthquake Affected
7. Hospitals May Face Funds Crunch
8. Australian Health funds stand accused
9. More Funds required for Asian Countries to fight Bird Flu
10. Shortage of NHS funds: Many Couples Denied Infertility Treatment
11. UK Woman To Raise Funds For Women Welfare
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2020)... ... September 01, 2020 , ... ... completed $3 million convertible note financing, which will be used to accelerate the ... funds from this financing, the company will continue to expand its customer base ...
(Date:8/31/2020)... ... August 31, 2020 , ... The Lymphoma Research ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... of Blood Cancer Awareness Month (BCAM) and its international Light it Red ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. Chang has over 20 ... and other developmental disabilities, as well as supporting staff in caring for patients ... school consultation, and staff development. She joined the company in 2015 as Chief ...
(Date:8/28/2020)... Calif. (PRWEB) , ... August 28, 2020 , ... ... cover a one-year subscription to a customized Lighthouse Health & Wellness mobile app ... support of this project. Motorola Solutions Foundation awards grants each year to organizations, ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... ... August 27, 2020 , ... Bleep LLC, maker of the ... apnea patient, is the company’s new spokesperson. , “In my line of work, a ... I found the Bleep DreamPort it was a Bleeping no brainer for me,” said ...
(Date:8/26/2020)... ... 26, 2020 , ... AseptiScope, a privately funded San Diego, California based, clinical ... MedTech Outlook. , “AseptiScope is pleased to receive this recognition,” said Kelly ... gloves on their hands, goggles on their eyes, covers on their shoes, and gowns ...
(Date:8/26/2020)... ... 2020 , ... Crossroads Hospice & Palliative Care Chief Compliance ... her name. , That’s thanks to her completion of two additional certifications this ... Officer (CPCO.) , The CHC is designed to mitigate compliance-related risks. Being ...
Breaking Medicine Technology: