Navigation Links
NIAID funds $51M contract to create comprehensive model of immune responses

A team of scientists is expanding efforts to develop a detailed picture of immune system function with a new $51 million, five-year contract from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The research builds on a project originally funded by NIAID in 2003, and will continue to be led by Richard Ulevitch, Ph.D., of The Scripps Research Institute in La Jolla, Calif. The contract will also involve scientists from the Institute for Systems Biology in Seattle; Stanford University in Palo Alto, Calif.; and the Australian National University, Canberra.

The collaborators on this project have previously made significant contributions to our understanding of innate immunity, the bodys first line of defense against infection, says NIAID Director Anthony S. Fauci, M.D. They are well-positioned to generate knowledge that will advance the development of new treatments, diagnostics and vaccines for infectious diseases that occur naturally or are deliberately introduced into a population.

According to Dr. Ulevitch, the researchers will use a systems biology approach to build a comprehensive model of the immune systems response to several disease-causing agents. Systems biology melds established life sciences with informatics, computer modeling and new techniques of gene and protein analysis to generate a wide-angle view of entire biological systems. To date, the team focused on developing an encyclopedic account of innate immunity. Now, the projects scope will broaden to encompass components of adaptive immunity, which includes antibodies and a diverse class of immune system cells called T cells. Dr. Ulevitch and his collaborators will create mutant mice and then screen them to find defects in the animals innate and adaptive immune reactions to viruses, including influenza, mousepox and mouse cytomegalovirus, and to several bacteria, including Salmonella and Listeria. Next, the group will conduct a systems-level analysis of the multiple immune system signaling pathways triggered by infection. The expanded project also will include studies aimed at determining the relevance to humans of genes and pathways discovered in mouse models.

We recognize that translating findings made with mouse models to their counterparts in the human immune system is a formidable challenge, says Dr. Ulevitch. But we have in place a multi-pronged approach that we believe will allow us to validate our mouse findings in human cells.

Finally, notes Dr. Ulevitch, the consortium will develop a Web-based data portal that will give the wider scientific community access to the data, animal models, antibodies and other scientific tools expected to be generated over the course of the contract. The scientific community at large will be able to use the Web resources without any specialized training in informatics or computational analysis, he notes.


Contact: Anne A. Oplinger
NIH/National Institute of Allergy and Infectious Diseases

Related medicine news :

1. The World Bank funds private Hospital in India
2. Shortage of funds for providing AIDS drug in Africa and India
3. Shortage Of Funds In Primary Care Trust In UK
4. Stop spending on new treatments; allocate funds to improve the existing treatments.
5. More Funds Are Required For Immunisation Drive
6. UN Calls For More Funds For Earthquake Affected
7. Hospitals May Face Funds Crunch
8. Australian Health funds stand accused
9. More Funds required for Asian Countries to fight Bird Flu
10. Shortage of NHS funds: Many Couples Denied Infertility Treatment
11. UK Woman To Raise Funds For Women Welfare
Post Your Comments:
(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015 ... of the company’s growing product line of food safety and seafood fraud prevention ... (Oncorhynchus nerka) – allow InstantLabs to offer fast, reliable species identification for the ...
(Date:12/1/2015)... York, NY (PRWEB) , ... December 01, 2015 ... ... of non-traumatic limb amputations in the United States. Podiatrists are well aware that ... to adopt therapeutic behaviors) are often catastrophic contributors to diseases of the diabetic ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... ... Center of Excellence (BHCOE) today announced that the organization has awarded Education and ... Francisco, with a Distinguished Award. The award celebrates exceptional special needs providers that ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... Effective Post-Affiliation Integration ,” addresses a main “pain point” for merging or aligning ... results, once a deal is signed. This quick-read guidance suggests that failing ...
(Date:12/1/2015)... Beverly Hills, CA (PRWEB) , ... December 01, ... ... honored by Modern Luxury’s Angeleno Magazine as a Modern Man for 2015. ... luxury lifestyle publisher in the United States. Established in 1994, Modern Luxury includes ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... and PITTSBURGH , Dec. ... announced that it expects to be the first to ... funded by international donors, TLE400 (Tenofovir Disoproxyl Fumarate 300 ... for $99 per patient, per year. Mylan partnered with ... The significantly reduced price could generate savings of tens ...
(Date:12/1/2015)... Dec. 1, 2015  Six months of adjunctive metformin therapy ... 1 diabetes, according to new research from T1D Exchange ... may have a beneficial effect on measures of obesity, including ... of the Journal of the American Medical Association , ... effect of metformin on overweight and obese adolescents with type ...
(Date:12/1/2015)... 2015 ... of the "2016 Europe Enteric ... Coli, Enterovirus, Rhinovirus, Rotavirus, Salmonella, Shigella, ... offering. --> ) ... "2016 Europe Enteric Disease Testing ...
Breaking Medicine Technology: