Navigation Links
NIAID awards contracts to search for protein markers of disease
Date:10/9/2008

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded two five-year contracts to establish Clinical Proteomics Centers for Infectious Diseases and Biodefense. The contracts were awarded to the University of Texas Medical Branch (UTMB), Galveston, and to the Canadian firm Caprion Proteomics, Montreal. Researchers at the centers will analyze human blood and other tissue samples from completed or ongoing clinical studies with the aim of discovering proteins that could serve as biomarkers of infectious disease.

A biomarker is a measurable biological substance that acts as an indicator of either health or disease. One biomarker test now used by doctors is the prostate-specific antigen (PSA) blood test for prostate cancer screening. Elevated levels of PSA protein in the blood may signal the presence of cancerous cells in the prostate gland.

Scientists at the new NIAID-funded centers will look for proteins produced either by disease-causing agents or by the immune system in response to infection. "Identifying specific biomarkers that are present in infected people--but absent in uninfected people--would give researchers new leads in understanding how microbes cause disease and how the body reacts to those microbes," says Maureen Beanan, Ph.D., a program officer in NIAID's Division of Microbiology and Infectious Diseases. This, in turn, could guide development of diagnostics, therapies or vaccines, she adds.

The first two diseases to be studied at the new centers will be dengue fever, a viral illness spread by mosquitoes, and brucellosis, a bacterial disease that can cause severe influenza-like symptoms. Once discovered and characterized, any candidate biomarkers found by the centers' scientists will be made freely available to the research community at large for further development.

The centers also will encourage clinical infectious disease researchers from other institutions to submit clinical samples to be assessed for the presence of potential biomarker proteins, notes Dr. Beanan. This service will be provided at no charge to the requestors.

The five-year contract to UTMB is estimated to be up to $10.9 million. The five-year contract to Caprion Proteomics is estimated to be up to $12.9 million.

Besides the new clinical proteomics centers, NIAID has established numerous research resources in the areas of bioinformatics, functional and structural genomics, and gene and protein sequencing. Together, these resources are assisting scientists to better understand interactions between disease-causing organisms and the human immune response. For more information about these resources, see http://www3.niaid.nih.gov/topics/pathogenGenomics.


'/>"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. NIAID funds $51M contract to create comprehensive model of immune responses
2. NIAID strengthens and expands Vaccine and Treatment Evaluation Units
3. NIAID scientists identify new cellular receptor for HIV
4. NIAID to convene HIV Vaccine Summit
5. NIAID describes research priorities to fight drug-resistant tuberculosis
6. NIAID to advance B-cell approach to HIV vaccines
7. NIAID creates HIV vaccine discovery branch
8. Corbett Selected to Host the Only Midwest Global Awards Judging Competition
9. Good Clinical Practice Journal Awards: Winners Announced
10. NIH awards $10.8M to Columbia to study connection between diabetes and heart disease
11. NIH awards Einstein multimillion dollar grant to extend studies of exceptional longevity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... advisory services for healthcare compliance program management, will showcase a range of technology ... Association for Assisted Living (NCAL) Convention and Expo to be held October 14–18, ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... in post-acute health care, have expanded their existing home health joint venture through ... AccentCare has been operating a joint venture home health company with Asante, delivering ...
(Date:10/12/2017)... ... , ... HMP , a leader in healthcare events and education, today announced ... Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie ... competition recognizes editorial and design excellence across a range of sectors. This year’s program ...
(Date:10/12/2017)... ... 12, 2017 , ... Women-owned and Grand Rapids-based workplace wellness ... in Wellness® by Best and Brightest. OnSite Wellness will be honored at the ... 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, located at ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  BioPharmX Corporation (NYSE ... team that developed an innovative way to use nonlinear ... the delivery of new drugs. ... Clinical Dermatology Conference will show how researchers from BioPharmX ... Harvard Medical School used a suite of imaging techniques ...
(Date:10/10/2017)... COUNTY, Calif. , Oct. 10, 2017  NDS received FDA ... Mobile  — a medical-grade battery-powered display stand specifically designed for endoscopy ... to transform technology into a clinical solution to support the improvement ... Innovative Design ... ZeroWire Mobile Wireless Solution ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology: