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NIAID announces vaccine adjuvant discovery contracts
Date:10/8/2009

ell responses that characterize long-term immunity.

The investigators also will seek to identify the cellular receptor for each of the novel adjuvant candidates, determine how it triggers the innate immune response, and then make changes to the adjuvant to improve its ability to induce the innate immune response. Although a number of innate immune receptors already have been described, many more likely exist and are expected to be uncovered in the course of these projects.

"The award of these contracts is an integral part of NIAID's long-range plan to expand the adjuvant pipeline," says Daniel Rotrosen, M.D., director of NIAID's Division of Allergy, Immunology, and Transplantation, which oversees these awards. "A first round of NIAID contracts, awarded in 2003, limited the discovery of novel adjuvants to those that stimulated the only group of innate immune receptors known at the time. With this second round of awards, we intend to increase the number of adjuvant candidates by expanding the research scope to include all known innate immune receptors."

The institutions receiving contracts for 2009 are

  • James R. Baker, Jr., M.D., University of Michigan, Ann Arbor
  • Dennis A. Carson, M.D., Moores Cancer Center, University of California San Diego, La Jolla
  • Sunil A. David, M.D., Ph.D., University of Kansas, Lawrence
  • Michael J. Gale, Jr., Ph.D., University of Washington School of Medicine, Seattle
  • David A. Johnson, Ph.D., Corixa Corporation (now part of GlaxoSmithKline Biologicals), Hamilton, Mont.
  • Peter Palese, Ph.D., Mount Sinai School of Medicine, New York City


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Contact: Julie Wu
wujuli@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

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