Navigation Links
NIA researchers find gene to explain mouse embryonic stem cell immortality
Date:3/24/2010

Researchers at the National Institute on Aging (NIA), part of the National Institutes of Health, have discovered a key to embryonic stem (ES) cell rejuvenation in a geneZscan4as reported in the March 24, 2010, online issue of Nature. This breakthrough finding could have major implications for aging research, stem cell biology, regenerative medicine and cancer biology.

ES cells are unique because, along with the ability to develop into nearly any type of cell in the body, they can produce infinite generations of new, fully operational ES cells (daughter cells). ES cells are essentially immortal, meaning that they can divide indefinitely to produce additional generations of functional ES daughter cells. Other cells can only produce a certain number of generations of daughter cells before they no longer function properly. This is partially because the telomere, the protective end of the chromosome which carries the cell's genetic information, shortens each time a cell divides. When a telomere becomes too short, it can no longer protect the cell. At that time, the cell dies, turns itself off, known as cell senescence, or produces abnormal and possibly dysfunctional cells.

Until now, the mechanism for the ES cell's immortality had been a mystery. The prevailing theory was that ES cells practiced "self-renewal," meaning that when they divided, they produced daughter cells that were completely unaltered (including telomere length) from the parent. NIA researchers discovered that the process occurring in ES cells can be more appropriately described as "rejuvenation" than the "self-renewal." As in other cells, when ES cells replicate, the daughter cells are not identical to the parent and the telomeres are shorter. However, ES cells express a unique Zscan4 gene that, when activated (or turned on), rejuvenates the ES cell, restoring it to its original vigor. This rejuvenation includes telomere lengthening through recombination, when a shorter telomere combines with a longer telomere to elongate itself. Zscan4 then turns off. The gene is not turned on every time that the cell replicatesapproximately 5 percent of the cells will have an activated gene at any one point. The process is a cycle of cell replication (with telomere shortening) and intermittent activation of Zscan4 (cell rejuvenation).

Researchers are currently investigating whether a similar mechanism also operates in human cells.


'/>"/>

Contact: Megan Homer
homerm@mail.nih.gov
301-496-1752
NIH/National Institute on Aging
Source:Eurekalert

Related medicine news :

1. Researchers discover fundamental step in immune-system development
2. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
3. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
4. Researchers find new chemotherapy combination shows promise in endometrial cancer
5. Researchers ID brain abnormalities in children exposed to methamphetamine in utero
6. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
7. Researchers discover chemical that may protect hearts of muscular dystrophy patients
8. Researchers recommend curriculum on unhealthy substance use
9. Using new approach, Mayo Clinic researchers find level of gene alters risk of Alzheimers disease
10. Researchers discover brain tumors grow-or-go switch
11. Exposure to BPA may cause permanent fertility defects, Yale researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... February 12, 2016 , ... CDRH Enforcement Trends: , Back to the Future , Feb. ... , As Winston Churchill said, “Those who don’t learn from history are doomed to repeat ... when they come knocking this year. But that takes time. , Take a close ...
(Date:2/12/2016)... ... 12, 2016 , ... T.E.N., a technology and information security ... Southeast Awards 2016. Finalists and winners of the ISE® Awards for both Executive ... Awards Gala on March 15, 2016 at the Westin Peachtree Plaza, Atlanta. ...
(Date:2/12/2016)... Washington, NC (PRWEB) , ... February 12, 2016 , ... ... the surrounding areas, is initiating a charity drive that will raise funds earmarked to ... at John C. Tayloe Elementary School. , “My school is in a low-income area ...
(Date:2/12/2016)... ... February 12, 2016 , ... Donor Network West, the organ procurement organization that ... partnership with San Ramon Regional Medical Center. Under the collaboration, the first of its ... to accommodate a more certain time frame for donor families for the recovery of ...
(Date:2/12/2016)... OR (PRWEB) , ... February 12, 2016 , ... ... an article about foods choices that promote eye health. These articles generally list ... health. Water and health advocate Sharon Kleyne endorses every one of these lists ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 11, 2016  NOIT™ Research LLC, a private, leading-edge ... Change" campaign to assist needy families in obtaining one ... sold between February 10, 2016 and March 31, 2016, ... family. The NOIT is an auditory stimulus that plays ... language skills. Beth Shier , NOIT ...
(Date:2/11/2016)... Feb. 11, 2016 AAIPharma Services Corp./Cambridge ... custom manufacturing and development services for the pharmaceutical ... capabilities and capacity in its Charleston, ... has driven several recent investments. ... one filling line with small-scale lyophilization. The site ...
(Date:2/11/2016)... and PORTLAND, Ore. , Feb. 11, ... company, is pleased to announce the acquisition of SolutionsRx, ... and rural access hospitals. Along with providing traditional contract ... consulting services to assist clients in navigating the complex ... , CEO of Wellpartner. --> James R. ...
Breaking Medicine Technology: