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NHLBI funds research to improve safety of red blood cell transfusions
Date:6/21/2010

which is conducting the trial.

The trial, part of the Transfusion Medicine/Hemostasis Clinical Trials Network, is led by principal investigator Marie Steiner, M.D., associate professor at the University of Minnesota Medical School, and will be conducted at multiple sites across the country, including Atlanta; Baltimore; Boston; Chapel Hill, N.C.; Durham, N.C.; Iowa City, Iowa; Minneapolis; New York City; New Brunswick, N.J.; Pittsburgh; and Seattle. Participants will be randomly assigned to receive blood that was stored for 10 or fewer days, or blood that was stored for 21 or more days. Researchers will track the participants' health and compare outcomes between the two groups, such as death rates one month following surgery; post-operative complications such as stroke, heart attack, kidney failure, pulmonary embolism (blockage of an artery in the lungs), and sepsis (a life-threatening infection); and the need for mechanical ventilation.

RECESS plans to enroll about 1,830 patients. Most RECESS sites expect to begin enrolling patients in early summer 2010, although additional sites may be added later. More information about the trial (NCT00991341) can be found at http://clinicaltrials.gov/.

Eight Grants for Blood Storage and Preparation

The NHLBI is also supporting eight different studies that will examine what changes red blood cell units undergo when they are prepared and stored, as well as whether those changes affect the blood vessels and tissues once transfused.

"These studies will lead to a better understanding of the changes that occur as a function of red blood cell preparation and storage time and their effect, if any, when transfused," said Simone Glynn, M.D., chief of the Transfusion Medicine and Cellular Therapeutics Branch in the NHLBI's Division of Blood Diseases and Resources. "The results of this work could lead to improved red blood cell therapies th
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Contact: NHLBI Communications Office
NHLBI_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

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