NEWSWEEK: Media Lead Sheet/April 21, 2008 Issue (on newsstands Monday, ...(sweek.com/id/131761 target _new http://...),Health

RELIGION: "Why This Pope Doesn't Connect" (p. 41). Senior Editor Lisa Miller writes that Pope Benedict XVI has done little to appeal to Americans in need of serious spiritual catharsis. "It's not just that Benedict pales in comparison to his predecessor John Paul II in almost every respect," Miller writes. "It's that Benedict himself has done very little to win the hearts of his American flock at what may be the most critical moment in their history."

http://www.newsweek.com/id/131837

SHARON BEGLEY: "A New Reason to Frown" (p. 45). Senior Editor Sharon Begley writes that researchers at Italy's Institute of Neuroscience found that the botulinum in Botox can reach nerve cells in the brain and spine. Researchers injected rats and mice with botulinum neurotoxin A in doses comparable to those used in people. "Neurons at the injection site -- the whisker muscles -- absorbed some of the toxin and passed it along to other neurons they connected to ... Within three days, the toxin had migrated from the whisker muscles to the brainstem, where it disrupted neuronal activity," she writes.

http://www.newsweek.com/id/131749

MUSIC: "Where Have You Been?" (p. 57). Assistant Editor Joshua Alston reviews British band Portishead's long awaited third album called "Third," and interviews band members on the 11-year gap between this and the previous album. Portishead fans know that the time elapsed between albums was almost inevitable. But when asked about it, instrumentalist Adrian Utley told Alston, "We have to operate this way to make it work. I don't even understand the criticism of perfectionism, really. It's just about wanting things to be correct."

http://www.newsweek.com/id/131756 '/>"/>