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NEJM study shows combination treatments benefit melanoma patient
Date:3/7/2012

s, allowing the immune system to function more robustly and leading to better recognition and control of the disease."

Together, these data showed that radiation given locally can impact the immune system globally. Today, the patient continues to have a durable regression of melanoma both within and outside of the irradiated field. In the study, researchers followed the patient for seven years from her initial diagnosis of melanoma in 2004 through a series of treatments and eventual disease regression in April 2011 after a combination treatment of radiation and immunotherapy.

"The immune system differs in each of us. In studying one person's response, we were able to carefully investigate the clinical findings with in-depth laboratory studies, which suggested that a change in the immune system was vital to the successful results," added Dr. Wolchok.

The patient's dramatic systemic response following targeted radiation therapy in combination with immunotherapy has spurred interest in pursuing clinical trials to further validate this approach for prostate cancer and melanoma.


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Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

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