Navigation Links
NEJM study shows combination treatments benefit melanoma patient
Date:3/7/2012

New York, NY, March 8, 2012 Research published today in the New England Journal of Medicine by scientists at the Ludwig Institute for Cancer Research (LICR) and Memorial Sloan-Kettering Cancer Center (MSKCC) showed that combining targeted radiation therapy with immunotherapy (ipilimumab), fostered a strong immune response and a favorable clinical outcome in a patient with melanoma, the most dangerous form of skin cancer. The size of both the tumor that was treated with radiation and distant tumors in the patient were reduced. This study is a rare example of a documented case of an immune response, known as the abscopal effect, in cancer treatment.

The research team led by Jedd Wolchok, M.D., Ph.D., Assistant Member of LICR, Associate Attending Physician and Director of Immunotherapy Clinical Trials at MSKCC and Director of the CRI/LICR Cancer Vaccine Collaborative, took their findings a step further by investigating how the immune system may have played a role in the enhanced tumor regression. "We evaluated whether there were changes in the blood, which would help us to understand why the combined ipilimumab/radiation treatment improved the patient's response," said Dr. Wolchok.

What the team found was that the patient had a pre-existing immune response to an antigen known as NY-ESO-1, which was discovered by LICR researchers more than a decade ago. Select cancer patients produce antibodies and develop T-cell responses to NY-ESO-1, and research has shown that cancer patients who have pre-existing immunity to NY-ESO-1 are more likely to respond to the immunotherapy treatment, ipilimumab, than those who do not.

"The use of radiation therapy modulated the patient's immune system, resulting in an increased antibody response to one portion of the NY-ESO-1 protein, as well as increased antibody responses to other antigens," said Dr. Wolchok. "In addition, the radiation decreased the level of a population of suppressive cells, allowing the immune system to function more robustly and leading to better recognition and control of the disease."

Together, these data showed that radiation given locally can impact the immune system globally. Today, the patient continues to have a durable regression of melanoma both within and outside of the irradiated field. In the study, researchers followed the patient for seven years from her initial diagnosis of melanoma in 2004 through a series of treatments and eventual disease regression in April 2011 after a combination treatment of radiation and immunotherapy.

"The immune system differs in each of us. In studying one person's response, we were able to carefully investigate the clinical findings with in-depth laboratory studies, which suggested that a change in the immune system was vital to the successful results," added Dr. Wolchok.

The patient's dramatic systemic response following targeted radiation therapy in combination with immunotherapy has spurred interest in pursuing clinical trials to further validate this approach for prostate cancer and melanoma.


'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... February 17, 2017 , ... Like most hospitals across ... Driven in large part by the Hospital Readmission Reduction Program (HRRP), the return of ... focus area for hospitals across the nation. While many providers are struggling to leverage ...
(Date:2/17/2017)... ... 17, 2017 , ... The Mason Pasquin Agency, a Virginia-based ... owners in and around the Hampton Roads metropolitan region, is joining the local ... domestic violence. , There are multiple categories of domestic violence – physical abuse ...
(Date:2/16/2017)... ... February 17, 2017 , ... Harsha ... 10 years of research, development and clinical trials, the founder of Chigurupati Technologies ... patented compound of FDA approved ingredients that when infused into alcohol, protect the ...
(Date:2/16/2017)... ... 17, 2017 , ... Teaching nursing care of vulnerable children is the focus ... is being created with the support of the Hearst Foundations. An initiative of the ... address what has been identified as a critical gap in preparing the next generation ...
(Date:2/16/2017)... Mt. Kisco, New York (PRWEB) , ... February ... ... Westchester Hospital’s (NWH) nursing professionalism, teamwork and superiority in patient care, NWH ... Chair of the Commission on Magnet on Tuesday, January 31, 2017. The American ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , February 17, 2017 ... the S&P 500 edged lower at the closing bell, ... streak above the 20,000 benchmark. Moreover, five out of ... Taking into consideration yesterday,s market sentiment, Stock-Callers.com assessed the ... & Nephew PLC (NYSE: SNN ), ABIOMED ...
(Date:2/16/2017)... Research and Markets has announced the ... Technologies" report to their offering. ... Traditional medical devices include ... non-drug coated implantables, large endoscopes, needle based drug delivery, lab ... last two to three decades for the treatment and management ...
(Date:2/16/2017)... -- The global preparative and process chromatography market is ... USD 5.49 billion in 2016, at a CAGR of ... the preparative and process chromatography market is segmented into ... chromatography segment is expected to account for the largest ... in this segment can primarily be attributed to the ...
Breaking Medicine Technology: