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NEJM study shows combination treatments benefit melanoma patient
Date:3/7/2012

New York, NY, March 8, 2012 Research published today in the New England Journal of Medicine by scientists at the Ludwig Institute for Cancer Research (LICR) and Memorial Sloan-Kettering Cancer Center (MSKCC) showed that combining targeted radiation therapy with immunotherapy (ipilimumab), fostered a strong immune response and a favorable clinical outcome in a patient with melanoma, the most dangerous form of skin cancer. The size of both the tumor that was treated with radiation and distant tumors in the patient were reduced. This study is a rare example of a documented case of an immune response, known as the abscopal effect, in cancer treatment.

The research team led by Jedd Wolchok, M.D., Ph.D., Assistant Member of LICR, Associate Attending Physician and Director of Immunotherapy Clinical Trials at MSKCC and Director of the CRI/LICR Cancer Vaccine Collaborative, took their findings a step further by investigating how the immune system may have played a role in the enhanced tumor regression. "We evaluated whether there were changes in the blood, which would help us to understand why the combined ipilimumab/radiation treatment improved the patient's response," said Dr. Wolchok.

What the team found was that the patient had a pre-existing immune response to an antigen known as NY-ESO-1, which was discovered by LICR researchers more than a decade ago. Select cancer patients produce antibodies and develop T-cell responses to NY-ESO-1, and research has shown that cancer patients who have pre-existing immunity to NY-ESO-1 are more likely to respond to the immunotherapy treatment, ipilimumab, than those who do not.

"The use of radiation therapy modulated the patient's immune system, resulting in an increased antibody response to one portion of the NY-ESO-1 protein, as well as increased antibody responses to other antigens," said Dr. Wolchok. "In addition, the radiation decreased the level of a population of suppressive cell
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Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

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