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NEJM study demonstrates carotid stenting with embolic protection is comparable to surgery
Date:4/10/2008

id revascularization and carotid surgery, said Donald E. Cutlip, M.D., Executive Director of Clinical Investigation, Harvard Clinical Research Institute, Harvard Medical School. Dr. Cutlip currently serves as an investigator in the Cordis-sponsored SAPPHIRE study.

SAPPHIRE is the first, longest-term randomized study comparing the safety and efficacy of carotid stenting with embolic protection to those undergoing endarterectomy or surgery in patients considered at a high surgical risk. Carotid artery stenting is a minimally invasive procedure that involves placement of a stent, a wire mesh device used to open a narrowed artery, up to the neck through a catheter near the leg. To reduce the chances of small pieces of plaque breaking off and entering the bloodstream during this process, SAPPHIRE researchers used an emboli-protection device to catch these small particles. The PRECISE Stent and ANGIOGUARD Guidewire are approved to treat carotid artery disease in patients at high risk for adverse events from carotid endarterectomy (CEA) -- a surgical treatment for removing arterial plaque from the carotid artery.

These long-term study results are important to the approximately one-third of patients who have severe carotid artery stenosis and require a less invasive, but effective treatment option because they are poor candidates for surgery, said Sidney Cohen, M.D., Ph.D., Vice President, Clinical Research, Cordis Corporation. Results show that stenting with the PRECISE Nitinol Stent combined with the ANGIOGUARD distal protection device offers these patients a safe and effective alternative to carotid surgery.


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Contact: Amy Meshulam
amy.meshulam@edelman.com
323-202-1028
Edelman Public Relations
Source:Eurekalert

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