Navigation Links
NEJM: Low-fat diets not best for weight loss: New study by Ben-Gurion U. of the Negev
Date:7/16/2008

NEW YORK, July 14, 2008 A two-year study led by researchers from Ben-Gurion University of the Negev (BGU) reveals that low-carbohydrate and Mediterranean diets may be just as safe and effective in achieving weight loss as the standard, medically prescribed low-fat diet, according to a new study published in the prestigious New England Journal of Medicine.

The study was conducted by BGU and the Nuclear Research Center in Dimona, Israel, in collaboration with Harvard University, The University of Leipzig, Germany and the University of Western Ontario, Canada.

In the two-year study, 322 moderately obese people were intensively monitored and were randomly assigned one of three diets: a low-fat, calorie-restricted diet; a Mediterranean calorie-restricted diet with the highest level of dietary fiber and monounsaturated/saturated fat; or a low-carbohydrate diet with the least amount of carbohydrates, highest fat, protein, and dietary cholesterol. The low-carb dieters had no caloric intake restrictions.

Although participants actually decreased their total daily calories consumed by a similar amount, net weight loss from the low-fat diet after two years was only 6.5 lbs. (2.9 kg) compared to 10 lbs. (4.4 kg) on the Mediterranean diet, and 10.3 lbs. (4.7 kg) on the low-carbohydrate diet. "These weight reduction rates are comparable to results from physician-prescribed weight loss medications," explains Dr. Iris Shai, the lead researcher.

The low-fat diet reduced the total cholesterol to HDL ratio by only 12 percent, while the low-carbohydrate diet improved the same ratio by 20 percent. Lipids improved the most in the low-carbohydrate, with a 20% increase in the HDL ("good") cholesterol and, 14% decrease in triglycerides. In all three diets, inflammatory and liver function biomarkers was equally improved. However, among diabetic participants, the standard low-fat diet actually increased the fasting glucose levels by 12mg/dL, while the Mediterranean diet induced a decrease in fasting glucose levels by 33mg/dL.

In addition to the findings, this two-year study is also significant because of the relatively large number of participants coupled with a low drop-out rate 95 percent were in the study after one year and 85 percent were still participating after the second.

Dr. Iris Shai is a researcher at the S. Daniel Abraham International Center for Health and Nutrition in the Department of Epidemiology at Ben-Gurion University of the Negev. She conceived the study with Dr. Stampfer, the senior author, while she was a Fulbright fellow at Harvard School of Public Health and Channing Laboratory in Boston, Massachusetts.

The trial conducted at the Nuclear Research Center in Israel involved unparalleled and significant cooperation between staff, participants and their spouses. The cafeterias in the workplace went through a "health revolution," integrating the workplace cafeteria managers with clinical support and a nutritional advisor, in order to provide healthy food dishes that would fit each one of the dietary arms, as labeled with specific colors every day. Along with careful workplace nutritional counseling, spouses of the trial participants were educated on how to keep the specific assigned diet strategy at home. The participants also completed electronic questionnaires, developed specifically for the study.

"The Nuclear Research Center Dimona highly values health promotion within the workplace," said Dr. Dan Schwarzfuchs, director of the clinical department at the facility. "This is why it supported performance of such a nutritional study and enabled the outstanding adherence rate of the DIRECT participants."

"Clearly, there is not one diet that is ideal for everyone," Shai concludes. "We believe that this study will open clinical medicine to considering low-carb and Mediterranean diets as safe effective alternatives for patients, based on personal preference and the medical goals set for such intervention. Furthermore, the improvement in levels of some biomarkers continued until the 24-month point, although maximum weight loss was achieved by 6 months. This suggests that healthy diet has beneficial effects beyond weight loss."


'/>"/>

Contact: Andrew Lavin
alc@alavin.com
516-353-2505
American Associates, Ben-Gurion University of the Negev
Source:Eurekalert

Related medicine news :

1. Media availability: low-fat dietary pattern may lower risk of ovarian cancer
2. Low-Carb Diets Better Than Low-Fat Diets at Preventing Diabetes
3. The Low-Fat Diet is Fueling Our Rate of Obesity, Says Researcher Phoenix Gilman
4. Low-Fat Dairy Reduces High Blood Pressure Risk
5. eDiets.com(R) Updates Timing of Third Quarter 2007 Earnings Conference Call
6. Cancer risks for urban African-American women grow, healthy diets more difficult to maintain
7. Diets May Raise Cancer Risk for Poor, Urban Women
8. Far flung food: Europes distant diets
9. Diabetes Group Backs Low-Carb Diets
10. Nations Leading Dialysis Provider - DaVita - Partners with eDiets(R) to Launch One-of-a-Kind Diet Helper Online Nutrition and Meal Planning Tool for Late-Stage Kidney Disease Patients and Caregivers
11. eDiets.com, Inc. Announces Resignation of Robert Hamilton, Chief Financial Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Finally, a bruise cream that really ... cream can be incorporated into the post-surgical treatment plans of a variety of other ... dermaka cream is very effective for bruising and causes a rapid resolution of bruising ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Seema Daulat, a native Texan and University ... Lamar location as of July 13, 2016. , Dr. Daulat earned her Doctorate of ... she regularly volunteered at the Agape Clinic serving Dallas’ underprivileged community. , Following medical ...
(Date:6/23/2016)... ... 23, 2016 , ... SyncDog, Inc. , the leading ... is featured in the current issue of Silicon Review magazine. Silicon ... technology solutions and features them in their magazine. The magazine allows top-level executives ...
(Date:6/23/2016)... ... 23, 2016 , ... The U.S. Supreme Court decision on immigration has significant ... The Senior Citizens League (TSCL) . “President Obama’s executive actions on immigration would ... who worked in this country illegally, even though the newly - issued green cards ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016  Arkis BioSciences, a leading innovator in ... durable cerebrospinal fluid treatments, today announced it has ... is led by Innova Memphis, followed by Angel ... investors.  Arkis, new financing will accelerate the commercialization ... release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... 2016 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated testing ... With this clearance, Roche is the first IVD company ... for sepsis risk assessment and management. PCT ... PCT levels in blood can aid clinicians in assessing ...
Breaking Medicine Technology: