Navigation Links
NCI study finds extreme obesity may shorten life expectancy up to 14 years
Date:7/8/2014

Adults with extreme obesity have increased risks of dying at a young age from cancer and many other causes including heart disease, stroke, diabetes, and kidney and liver diseases, according to results of an analysis of data pooled from 20 large studies of people from three countries. The study, led by researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, found that people with class III (or extreme) obesity had a dramatic reduction in life expectancy compared with people of normal weight. The findings appeared July 8, 2014, in PLOS Medicine.

"While once a relatively uncommon condition, the prevalence of class III, or extreme, obesity is on the rise. In the United States, for example, six percent of adults are now classified as extremely obese, which, for a person of average height, is more than 100 pounds over the recommended range for normal weight," said Cari Kitahara, Ph.D., Division of Cancer Epidemiology and Genetics, NCI, and lead author of the study. "Prior to our study, little had been known about the risk of premature death associated with extreme obesity."

In the study, researchers classified participants according to their body mass index (BMI), which is a measure of total body fat and is calculated by dividing a person's weight in kilograms by their height in meters squared. BMI classifications (kilogram/meter-squared) are:

  • Normal weight: 18.5-24.9
  • Overweight: 25.0- 29.9
  • Class I obesity: 30.0-34.9
  • Class II obesity: 35.0-39.9
  • Class III obesity: 40.0 or higher

The 20 studies that were analyzed included adults from the United States, Sweden and Australia. These groups form a major part of the NCI Cohort Consortium, which is a large-scale partnership that identifies risk factors for cancer death. After excluding individuals who had ever smoked or had a history of certain diseases, the researchers evaluated the risk of premature death overall and the risk of premature death from specific causes in more than 9,500 individuals who were class III obese and 304,000 others who were classified as normal weight.

The researchers found that the risk of dying overall and from most major health causes rose continuously with increasing BMI within the class III obesity group. Statistical analyses of the pooled data indicated that the excess numbers of deaths in the class III obesity group were mostly due to heart disease, cancer and diabetes. Years of life lost ranged from 6.5 years for participants with a BMI of 40-44.9 to 13.7 years for a BMI of 55-59.9. To provide context, the researchers found that the number of years of life lost for class III obesity was equal or higher than that of current (versus never) cigarette smokers among normal-weight participants in the same study.

The accuracy of the study findings is limited by the use of mostly self-reported height and weight measurements and by the use of BMI as the sole measure of obesity. Nevertheless, the researchers noted, the results highlight the need to develop more effective interventions to combat the growing public health problem of extreme obesity.

"Given our findings, it appears that class III obesity is increasing and may soon emerge as a major cause of early death in this and other countries worldwide," said Patricia Hartge, Sc.D., Division of Cancer Epidemiology and Genetics, and senior author of the study.


'/>"/>

Contact: NCI Press Officers
ncipressofficers@mail.nih.gov
301-496-6641
NIH/National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Study shows link between inflammation in maternal blood and schizophrenia in offspring
2. Study reveals protective role for specialized cells in intestinal and respiratory systems
3. Infant toenails reveal in utero exposure to low-level arsenic, Dartmouth study finds
4. $12.6 million NIH grant to study genetics of Alzheimers disease
5. New study reveals how tumors remodel their surroundings to grow
6. Study finds higher risk for celiac disease in some children
7. New study will discover why women freeze their eggs
8. New study discovers biological basis for magic mushroom mind expansion
9. Twin study links community socioeconomic deprivation to sleep duration
10. GW researcher receives more than $1 million in grants to study epigenetics of pancreatic cancer
11. Study finds online bullying creates off-line fear at school
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2016)... ... , ... TLC Laser Eye Centers announced today that it has acquired Gordon ... be called “Gordon Schanzlin New Vision Institute, a TLC Laser Eye Center.” , ... ensure that patients continue to receive the highest quality of care. In addition, all ...
(Date:5/5/2016)... ... 05, 2016 , ... LELO has discovered many people are insecure ... out via email, social media and on the Volonté blog seeking advice about how ... masturbate ‘normal’ or ‘correct’?” , While some methods are more common than others, there ...
(Date:5/5/2016)... ... May 05, 2016 , ... ... master charity program created to assist the people of their local community. The ... nonprofit organizations and community leaders. Their hope is to bring awareness to important ...
(Date:5/5/2016)... ... May 05, 2016 , ... Vitenas Cosmetic Surgery has ... Awards, presented by the American Institute of Architects and the Academy of Architecture for ... renowned Perkins+Will and Harrell Architects, opened to patients in October of 2014. ...
(Date:5/5/2016)... ... 2016 , ... Sun Health registered nurse Brittany Eads and ... Care Transitions program at the 9th Annual Orthopedic and Spine Summit held ... Post-Acute Environment Through Effective Transitions of Care.” , Major changes are taking place ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... Progra m m e ... Oxitec , s mosquito in Cayman Islands ... by 96 %   Oxitec and the Cayman ... wild Aedes aegypti, the dangerous mosquito that spreads dengue, Zika and ... Grand Cayman .  MRCU, a global leader in mosquito control, is ...
(Date:5/5/2016)... , May 5, 2016 /PRNewswire/ ... announced the addition of the  "Europe ... - 2016"  report to their offering.  ... ) , ,The latest research ... Highlights - 2016, provides comprehensive insights ...
(Date:5/4/2016)... May 4, 2016  Compass Diversified Holdings (NYSE: ... an owner of leading middle market businesses, announced today ... March 31, 2016. First Quarter 2016 Highlights ... Reinvestment ("CAD" or "Cash Flow") of $13.6 million for ... loss of $15.0 million for the first quarter of ...
Breaking Medicine Technology: