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NCI renews Fox Chase/Penn Ovarian Cancer 'SPORE' grant for a third 5-year term
Date:9/4/2009

ase, and Timothy Rebbeck, M.D., Penn.

While well known for their involvement in breast cancer, mutations in the BRCA1 and BRCA2 genes whether inherited or acquired -- also contribute to ovarian cancer. The risk of these mutations, and how to counsel BRCA1/2 mutation carriers, is less well understood. The team lead by Daly and Rebbeck seeks to identify extent of risk factors related to BRCA1/2-associated ovarian cancers and to develop a methodology by which to counsel carriers of the mutation on treatment options including prophylactic removal of the ovaries.

3. Therapeutic Micro RNA Strategies for Ovarian Cancer, co-lead by Lin Zhang, M.D., and Peter. O'Dwyer, M.D. from Penn, and Thomas Hamilton, Ph.D., of Fox Chase

Malignant epithelial ovarian cancer is one of the most common and lethal forms of ovarian cancer. While new therapies have led to increased survival, these patients typically relapse within a few years with a more resistant form of the disease. Recently, the Penn SPORE investigators have found evidence that microRNAs tiny segments of RNA have a role in ovarian cancer and could serve as a biomarker for early diagnosis. These microRNAs, which usually help regulate how genes are read, or expressed, are often themselves deregulated in ovarian cancer. Therefore, the researchers believe that microRNAs might be able to help restore the regulation of genes in ovarian cancer and might serve as a therapeutic or enhance the effect of chemotherapy.

4. Targeting Signaling Networks Via Novel RNAi Approaches to Improve Therapy for Ovarian Cancer, co-lead by Fox Chase researchers Andrew Godwin, Ph.D., Erica Golemis, Ph.D., and Russell Schilder, M.D.

While a single genetic mutation might initiate cancer, most tumors have evolved multiple mutations by the time the cancer is diagnosed. This team of researchers plans to use so-called silencing RNA (siRNA) technology to piece together the effects of silencing individual cancer gen
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Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

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