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NCI renews Fox Chase / Penn Ovarian Cancer 'SPORE' grant for a third 5-year term
Date:9/3/2009

es along the EGFR signaling pathway in epithelial ovarian cancer. The overall objective is to identify how sets of genes that interact could be attacked through siRNA strands, drugs or combinations thereof, which could then be brought to Phase 1 trials in the clinic.

5. Advancing T Cell Therapy for Ovarian Cancer, co-lead by Penn researchers George Coukos, M.D., Ph.D., Carl June, M.D. and Daniel Powell, Ph.D.

The human immune system is still the most powerful means of attacking disease, however, it has proven difficult to harness this power to fight cancer cells. Over the past five years of SPORE funding, the team lead by Coukos and June have made great progress in understanding the mechanisms by which tumors evade the immune system and how to disable these mechanisms. The researchers will conduct a Phase I/II clinical trial that will modify a patient's own T cells and then use those T cells in combination with chemotherapy to further stimulate the immune system to attack its own cells.


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Contact: Greg Lester
gregory.lester@fccc.edu
215-728-2753
Fox Chase Cancer Center
Source:Eurekalert

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