Navigation Links
NCI awards $19.3m for multisite investigation of cancer disparities
Date:8/25/2011

Why are African-American women more likely than those of European descent to be diagnosed with breast cancer at a young age, and with poor prognoses? It's a provocative question, and one that a multidisciplinary team from the Slone Epidemiology Center at Boston University (BU), the University of North Carolina Lineberger Comprehensive Cancer Center (UNC) and Roswell Park Cancer Institute (RPCI) are coming together to address, supported by a five-year, $19.3 million award from the National Cancer Institute (NCI).

This "team science" effort to better understand a significant health disparity will be led by Co-Principal Investigators Julie Palmer, ScD, from BU, Robert Millikan, PhD, from UNC's Lineberger Comprehensive Cancer Center and Christine Ambrosone, PhD, from RPCI. They will collaborate with a team of researchers in a national study investigating the causes of breast cancer among African-American women. For reasons that are not clear, African-American women are more likely than women of European descent to be diagnosed before age 45, and are also more likely to be diagnosed with aggressive types of breast cancer that are linked to more deaths.

The study, the largest to date on breast cancer in African-American women, will involve 5,500 African-American women from four ongoing studies the Carolina Breast Cancer Study (CBCS), the Women's Circle of Health Study (WCHS), the Black Women's Health Study (BWHS) and the Multiethnic Cohort Study (MEC) as well as 5,500 controls, or healthy women. Until now, studies on breast cancer in African-American women have been hampered by not having a large population to investigate risk factors for specific subtypes of breast cancer and for breast cancer diagnosed at an early age.

The investigation will be the first to develop comprehensive models for contributions of genetic and non-genetic risk factors for breast cancer subtypes in African-American women. The collaborators' goal is to discover genetic, biologic, reproductive and behavioral risks for breast cancer subgroups defined by tumor biology and age at onset of disease.

"We've known about these disparities for years, but not what's causing them," said Dr. Ambrosone, Professor of Oncology and Chair of the Department of Cancer Prevention and Control, Division of Cancer Prevention and Populations Science, RPCI. "Drs. Millikan, Palmer and I are passionate about this work, and we're joining forces in an effort to identify factors that can ultimately be used to prevent this deadly disease."

The researchers will apply a multi-faceted approach, investigating genetic susceptibility; reproductive history, lactation, and hormonal factors; body size, early life and adult physical activity; gene/environment interactions; and other risk factors in relation to breast cancer subtypes.

African-American women under age 45 have a 76 percent five-year survival rate from breast cancer, while young white women have an 88 percent survival rate (statistics for 2001-2007, the most recent period for which data are available).

The studies that form the foundation for this Program Project, or P01, award have been funded by a number of sources: the NCI (BWHS, CBCS, MEC and WCHS); NCI Specialized Program of Research Excellence in Breast Cancer (SPORE) and the North Carolina University Cancer Research Fund (CBCS); and the Department of Defense Breast Cancer Research Program, the Breast Cancer Research Foundation and a gift from the Philip H. Hubbell family (WCHS).


'/>"/>

Contact: Jenny Eriksen
jenny.eriksen@bmc.org
617-638-6841
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Elsevier congratulates Dr. Charles Silverstein upon his receipt of 2 awards
2. NIH awards WSU researcher $1.39M to study chromatins role in cell division
3. BIDMC scientists receive Challenge Awards from Prostate Cancer Foundation
4. NIH awards WSU researcher $1.7 million to study non-alcoholic fatty liver disease
5. The Samuel Waxman Cancer Research Foundation awards more than $3.1 million in grants
6. Nature Publishing Group supports ASCB Childcare Awards for scientist-parents at annual meeting
7. AOSSM presents prestigious research awards at annual meeting
8. Stanford Woods Institute awards Environmental Venture Projects
9. Three senior Hebrew University faculty members receive Kaye Awards for innovations
10. Damon Runyon Cancer Research Foundation awards $3.45 million to 9 top young clinical investigators
11. BUS Jeffrey H. Samet, M.D., selected as a 2011 NIDA International Program Awards of Excellence winner
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... Ca (PRWEB) , ... May 24, 2017 , ... ... effects and background. Understanind and choosing the most appropriate instruments for research and ... critical in research finding. This webinar will focus on innovations in stereo microscopy ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... ... dental implants in Bayside, NY, who have now spent 10 years as clinical ... New York University (NYU) College of Dentistry. Through the program, private practitioners receive ...
(Date:5/24/2017)... ... May 24, 2017 , ... Myers Jackson is well known for auctioning homes ... luxury homes anywhere on the planet. The luxury home market is alive and well ... city-scapes. A quick search of “11 Spyglass Hill Auction will enlighten you on the ...
(Date:5/24/2017)... ... 24, 2017 , ... Accordant Technology, a trusted IT solutions ... an analytics-first approach, layered with machine learning, that provides real-time visibility into the ... cloud to the edge. Through the new partnership, customers get the real-time situational ...
(Date:5/24/2017)... ... May 24, 2017 , ... The CFOs included ... and health systems in the nation and help their organizations navigate the challenges ... and been instrumental in developing successful hospital and health system strategy. , Becker's ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... Israel , May 4, 2017  DarioHealth Corp. ... mobile health and big data solutions, today announced that ... A&D Company, and STI Technologies Limited to lower diabetes ... immediately. Through STI,s innoviCares card, which is available throughout ... , DarioHealth customers will be eligible for additional savings ...
(Date:5/3/2017)... May 3, 2017  Kalorama Information notes that ... percent next year and this is projected to ... stem cell (HSCT) or bone marrow transplants require ... are well-suited for this task. This according to ... Kalorama Information. The various PCR-based methodologies, Sanger sequencing ...
(Date:5/2/2017)... , May 2, 2017  George Clinical, a ... region, and Vector Oncology, a ... and data analytics, formally announced today that George Clinical ... the transaction has the dual purpose of strengthening ... led oncology trial delivery solutions throughout the ...
Breaking Medicine Technology: