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NCI awards $11.5 million to Fred Hutchinson Cancer Research Center to lead breast cancer consortium
Date:11/11/2010

nd poor response to systemic therapy Using PET and MRI imaging to measure glucose metabolism and blood flow, respectively, in patients with locally advanced breast tumors, Hutchinson Center researchers have identified a "metabolic signature" indicative of breast cancers that become resistant to systemic chemotherapy, which increases the likelihood of early relapse and death. This project aims to better understand the underlying biology of drug-resistant tumors and develop treatments that overcome drug resistance. By using imaging technologies to identify drug-resistant tumors, such patients can be directed toward therapy that is more likely to work in the long term. Project co-leaders: David Hockenberry, M.D., a member of the Clinical Research Division at the Hutchinson Center; and David Mankoff, M.D., professor of radiology at UW School of Medicine.

Project 4: Identifying genetic biomarkers that could prevent over- or under-treatment in women with breast cancer The goal of this project is to identify markers of DNA damage repair as a way to predict outcome in breast cancer and prevent over- or under-treatment of the disease. Candidate biomarkers will be identified from tissue samples taken from a population-based group of approximately 2,000 survivors of invasive breast cancer who are being followed for recurrence and mortality. By identifying such markers, researchers hope to improve treatment decision-making. Project leader: Amanda Paulovich, M.D., Ph.D., an associate member of the Hutchinson Center's Clinical Research Division; project co-leader: Kathleen Malone, Ph.D., a member of the Hutchinson Center's Public Health Sciences Division.

Established by Congress in 1992, the SPORE program was created to promote collaboration between basic and applied scientists to speed the testing of new approaches to the prevention, early detection, diagnosis and treatment of a variety of cancers. The Hutchinson Center also leads SPORE initiatives in prostate
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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