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NCI awards $11.5 million to Fred Hutchinson Cancer Research Center to lead breast cancer consortium
Date:11/11/2010

b and into the clinic, where it will be made available to cancer patients enrolled in clinical studies, a process known as translational research.

Below are brief descriptions of each project.

Project 1: Predicting mortality and response to therapy Aggressive breast tumors often express abnormally low amounts of a cell cycle inhibitor called p27. Low levels of p27 are often a marker of poor outcome in breast cancer. This project will follow a small number of breast cancer patients who have survived at least five years to test the possibility that p27 expression in tumor cells predicts poor prognosis or poor response to anti-estrogen and/or anti-HER2 therapies. If this holds true, it will be possible to develop a test that will not only predict which women will fail treatment, but also will allow researchers new insight into which targeted therapies are needed to treat drug-resistant tumors. Project co-leaders: SPORE co-principal investigator Porter will lead this project along with James Roberts, M.D., Ph.D., a member of the Basic Sciences Division at the Hutchinson Center.

Project 2: Targeted T-cell immunotherapy of breast cancer This project will evaluate new immunotherapeutic approaches for breast cancer in a phase 1 clinical trial in which cells of the immune system will be isolated and programmed to target and kill breast cancer cells and then transferred back to the patient. The results of this research, which aims to kill cancer without harming healthy tissue, will provide insights into the potential utility of adoptive T-cell therapy for breast cancer, as well as the broader application of this approach for the treatment of other solid tumors. Project co-leaders: Stanley Riddell, M.D., a member of the Hutchinson Center's Clinical Research Division; and Lupe Salazar, M.D., an assistant professor of medicine in the Department of Oncology at the University of Washington School of Medicine.

Project 3: Predicting poor prognosis a
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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