Navigation Links
NCI awards $1.7 million to cancer specialist at Children's Hospital Los Angeles
Date:4/12/2011

LOS ANGELES (April 12, 2011) Fatih Uckun, MD, PhD, head of Translational Research in Leukemia and Lymphoma at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, and a research professor of Pediatrics at the Keck School of Medicine of the University of Southern California, has been awarded $1.7 million from the National Cancer Institute (NCI) to support development of a new strategy to overcome the resistance of cancer cells to radiation therapy.

In spite of promising advances in some forms of cancer, especially childhood leukemia, the overall progress in cancer therapy has remained modest due to the resistance of cancer cells to contemporary radiation and chemotherapy regimens. A team of researchers led by Dr. Uckun, an investigator at The Saban Research Institute and a member of the Developmental Therapeutics Program of the USC Norris Comprehensive Cancer Center, has recently discovered that radiation-resistant cancer cells can be made radiation-sensitive by specifically inactivating a molecular target comprised of three important signaling proteins, namely polo-like kinase 1 (PLK1), spleen tyrosine kinase (SYK) and STAT3 transcription factor.

The group's translational research shows that rationally designed inhibitors of this molecular target markedly improve the potency of radiation therapy in animal models of radiation-resistant cancer. With an earlier $2.5 million dollar grant from NCI and the support of the National Cancer Institute Alliance for Nanotechnology in Cancer, Dr. Uckun and his team have been developing nanoparticle formulations of these inhibitors as promising drug candidates against cancer.

The goal of this new grant is to allow Dr. Uckun to further optimize the clinical potential of his innovative strategy as part of a multidisciplinary effort to overcome radiation resistance of cancer cells. In addition, Dr. Uckun and colleagues will try to identify so-called "biomarkers" that will help clinicians predict which patients would be most likely to benefit from this new strategy.

"Our long-term goal is to develop biomarker-guided, personalized radiation therapy regimens that are both more effective and have fewer side effects," said Dr. Uckun. "We are grateful to NCI for this opportunity to work towards a practical solution for one of the most urgent unmet challenges in cancer therapy." The main therapeutic target for this five-year research project will be the most aggressive and radiation-resistant forms of childhood leukemia and will include detailed efficacy and safety studies to evaluate clinical potential of the lead experimental anti-cancer drug candidate.


'/>"/>

Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

Related medicine news :

1. NSF awards grant to University of Houston professor to develop color-coded MRIs
2. SEBM Young Investigator Awards for 2011
3. UCSD scientists receive prestigious Hartwell Biomedical Research Awards
4. American Cancer Society awards new research and training grants
5. AACR awards 50 minority scholar in cancer research awards
6. AACR and Landon Foundation support the next generation of researchers with INNOVATOR Awards
7. ESCEO Young Investigators Awards presented at ECCEO11-IOF in Valencia
8. Sea grant awards more than $1.1 million for research under EPAs Long Island Sound study
9. LRI awards wide-ranging research grants to drive next generation of scientific discovery in lupus
10. Bristol-Myers Squibb Foundation awards nearly $1M to HBV, HCV awareness, prevention and care
11. McKesson Foundation awards $1.3 million in 6 Mobilizing for Health Research grants
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NCI awards $1.7 million to cancer specialist  at Children's Hospital Los Angeles 
(Date:4/29/2016)... ... April 29, 2016 , ... ... Footwear Foundation, the national charitable foundation serving the footwear industry, has broken all ... representing more than 130 companies across 23 states during the months of April ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American ... productivity, stability, even security. Most importantly, employees are the single most important asset ... American workers so unhappy? , Just under half of American workers are emotionally ...
(Date:4/29/2016)... ... April 29, 2016 , ... A new ... with severe congenital diaphragmatic hernia have better survival rates if surgery is performed ... (CDH)—a condition where the diaphragm fails to form completely, letting abdominal organs into ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Gluten-Free Certification Program (GFCP), ... announce the launch of the GFCP Scoop in response to consumer ... of the GFCP Scoop site is to keep the gluten-free community ...
(Date:4/29/2016)... ... ... For those who skip meals occasionally (which is pretty much everyone), two ... new lifestyle diet tips offered by nutritionists Pam Bonney and Priya Lawrence of Tried ... Bonny and Lawrence noted that because proper nutrition, including water, provides energy during the ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... India , April 29, 2016 ... the life science laboratory due to the growing demands ... by advance technology, contemporary automated systems are already adept ... performed by slow, tedious and manual labor. Instrumentation continues ... were not even conceivable just a few years ago. ...
(Date:4/28/2016)... 2016 Dr. ... und Stephen Schmidt werden ... ArisGlobal®, ein führender Anbieter cloudbasierter Softwarelösungen für ... dass neue Führungskräfte zum Team Sicherheit und ... vielfältige Erfahrungen mitbringen.  Dies wird die Geschäftseinheit ...
(Date:4/28/2016)... Oramed Pharmaceuticals Inc. (NASDAQ: ... on the development of oral drug delivery systems, announced today ... conference, presented by Joseph Gunnar & Co. LLC, ... York . Nadav Kidron , CEO of Oramed, ... Presentation Details:   PIONEERS 2016, presented by ...
Breaking Medicine Technology: