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NCI awards $1.7 million to cancer specialist at Children's Hospital Los Angeles
Date:4/12/2011

LOS ANGELES (April 12, 2011) Fatih Uckun, MD, PhD, head of Translational Research in Leukemia and Lymphoma at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles, and a research professor of Pediatrics at the Keck School of Medicine of the University of Southern California, has been awarded $1.7 million from the National Cancer Institute (NCI) to support development of a new strategy to overcome the resistance of cancer cells to radiation therapy.

In spite of promising advances in some forms of cancer, especially childhood leukemia, the overall progress in cancer therapy has remained modest due to the resistance of cancer cells to contemporary radiation and chemotherapy regimens. A team of researchers led by Dr. Uckun, an investigator at The Saban Research Institute and a member of the Developmental Therapeutics Program of the USC Norris Comprehensive Cancer Center, has recently discovered that radiation-resistant cancer cells can be made radiation-sensitive by specifically inactivating a molecular target comprised of three important signaling proteins, namely polo-like kinase 1 (PLK1), spleen tyrosine kinase (SYK) and STAT3 transcription factor.

The group's translational research shows that rationally designed inhibitors of this molecular target markedly improve the potency of radiation therapy in animal models of radiation-resistant cancer. With an earlier $2.5 million dollar grant from NCI and the support of the National Cancer Institute Alliance for Nanotechnology in Cancer, Dr. Uckun and his team have been developing nanoparticle formulations of these inhibitors as promising drug candidates against cancer.

The goal of this new grant is to allow Dr. Uckun to further optimize the clinical potential of his innovative strategy as part of a multidisciplinary effort to overcome radiation resistance of cancer cells. In addition, Dr. Uckun and colleagues will try to identify so-called "biomar
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Contact: Ellin Kavanagh
ekavanagh@chla.usc.edu
323-361-8505
Children's Hospital Los Angeles
Source:Eurekalert  

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NCI awards $1.7 million to cancer specialist  at Children's Hospital Los Angeles 
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