Navigation Links
NCH investigators receive grant to distinguish bacterial infections from viral infections in infants
Date:9/30/2010

Octavio Ramilo, MD, chief of Infectious Diseases at Nationwide Children's Hospital, is one of three principal investigators who will share in a five-year, $3.4 million grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Dr. Ramilo and a team of more than 50 physicians across the United States are investigating the use of novel technologies for distinguishing between bacterial and viral infections in infants with fevers within emergency departments. This could lead to more rapid and accurate diagnoses and treatment for serious bacterial infections such as bacteremia and meningitis.

The multi-site study, including more than 20 children's hospitals within the Pediatric Emergency Care Applied Research Network (PECARN) network, will make use of RNA biosignatures biological indicators that can be identified from a blood test to distinguish infants presenting with fever who have bacterial infections from those infected with non-bacterial, or viral, pathogens.

The evaluation and management of febrile infants, especially those younger than 60 days of age, remains a challenge, particularly in hospital emergency departments. In fact, 6 to 10 percent of these infants arrive with serious, bacterial infections. Current tests to distinguish infants with these infections from those with benign viral illnesses can be invasive, inaccurate and time consuming, sometimes yielding false positive or false negative results. In addition, urine, blood and spinal fluid cultures typically take several days for final results.

"We plan to determine the host response to infection using RNA biosignatures that could help address some very challenging problems when evaluating these young, vulnerable infants," said Dr. Ramilo, also a faculty member at The Ohio State University College of Medicine. "This study could significantly improve the care we can provide to our youngest of patients when they arrive at an emergency department with a fever. We think it will give physicians and families quicker and precise information, helping avoid unnecessary tests and hospitalizations."

Dr. Ramilo is leading the study along with Dr. Nathan Kuppermann of UC Davis Health System in Sacramento and Dr. Prashant Mahajan of Children's Hospital of Michigan and Wayne State University. They are collaborating with colleagues at medical centers around the country as part of the PECARN network. Also involved in the study are Bema Bonsu, MD, an attending physician in the Emergency Department at Nationwide Children's Hospital and Daniel Cohen, MD, an associate director of Emergency Medicine at Nationwide Children's Hospital within the Emergency Department at Nationwide Children's and Asuncion Mejias, MD, an investigator at the Center for Vaccines and Immunity in The Research Institute at Nationwide Children's Hospital within Infectious Diseases.

"Bacterial infections likely carry very distinct biological signatures because they induce different host responses than nonbacterial pathogens," said Dr. Mejias. "We plan to use a type of molecular fingerprint technology to enable physicians to identify the specific markers in bacterial infections, as well as determine if such tests are feasible and practical in the emergency room setting."

There is a need to develop less invasive, highly accurate and timelier diagnostic strategies for febrile infants. Making use of new molecular tools, especially in emergency care, could ultimately help improve care for the youngest of patients, added Dr. Ramilo.


'/>"/>

Contact: Erin Pope
Erin.Pope@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Related medicine news :

1. Investigators examine colorectal cancer screening methods among diverse populations
2. UT Southwestern investigators perform head-to-head comparison of incontinence treatments
3. Damon Runyon Cancer Research Foundation awards $3.1M to 8 top young clinical investigators
4. Investigators identify gene associated with kidney disease in African-American population
5. SWOG names 5 cancer researchers outstanding Young Investigators
6. NACDD Receives Two-Year Grant From Merck & Co., Inc. to Improve Diabetes Education
7. Gladstones Robert Mahley to receive Research!America advocacy award
8. Patients with Lethal Lung Disease Finally Receive Recognition by Social Security Administration
9. Dr Yaghouti of Global Laser Vision Receives Patient's Choice Award for 2009
10. UT researcher receives $2.4 million to research obesity, high-risk pregnancy
11. BestMassage.com Receives Award for Customer Trust
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... 2017 , ... ProRehab Physical Therapy (PRPT) is ... therapy provider for Derby City CrossFit, effective immediately. , In addition to treating ... effectively as possible, ProRehab’s sports physical therapists will work with athletes to maximize ...
(Date:4/25/2017)... BC (PRWEB) , ... April 25, 2017 , ... The ... from Richmond, BC, who live with dental fear and require sedation to receive dental ... at ease during various procedures, from hygienic cleanings to oral surgery, at their ...
(Date:4/25/2017)... ... April 25, 2017 , ... Back Pain Centers ... back pain with a reputable physician in their area, announces the launch of a ... information for patients who are looking for reputable physicians to help them with back ...
(Date:4/25/2017)... ... 25, 2017 , ... There is no better place in South Florida to ... in the May issue of Consumer Reports focused on heart health. , The ... during and after coronary bypass and aortic valve replacement procedures. , Consumer Reports ...
(Date:4/24/2017)... ... 24, 2017 , ... Michael Vick announced his retirement earlier this year from ... overall number one pick in the 2001 NFL Draft, to the Atlanta Falcons, made ... the most career rushing yards by a quarterback (6,109) and the most rushing yards ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Zimmer Biomet Holdings, Inc. ... healthcare, today announced that it will be participating in ... at the InterContinental Hotel in Boston, Massachusetts ... will present at 11:20 a.m. Eastern Time. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
(Date:4/20/2017)... WOONSOCKET, R.I. , April 20, 2017 /PRNewswire/ ... (NYSE: CVS), today unveiled a new store design ... new assortment of healthier food, health-focused products and ... the store to help customers discover new offerings. ... represent the next evolution of the customer experience ...
(Date:4/20/2017)... Eyevensys, a private biotechnology company developing its ... that enables the safe, local, sustained production of therapeutic ... of ophthalmic diseases, announces it has received approval from ... to advance its technology into clinical development. ... The EyeCET platform uses ...
Breaking Medicine Technology: