Navigation Links
NCCS scientists discover gene regulation is dependent on protein ANP32E
Date:1/23/2014

Singapore, 23 January 2014 A team of scientists from the National Cancer Centre Singapore (NCCS), the Institut de Gntique et de Biologie Moleculaire et Cellulaire (Strassbourg France), and the Institut Albert Bonniot (Grenoble, France) have made an important finding on how genes are regulated. This study will be released in the January 30th, 2014 print issue of the journal Nature. The discovery used a genetically modified mouse that was developed by Dr Patrick Reilly, a Senior Scientist in the Laboratory of Inflammation Biology headed by Prof Tak Wah Mak at the NCCS, to demonstrate that the architecture of DNA in the living cell is maintained in part by a protein called ANP32E. The ANP32E or Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein in humans.

"While DNA is normally represented as a two strands forming a helix, the actual amounts of DNA in the cell mean that these strands must be compacted into complex structures, called chromatin, which restricts the DNA volume while still allowing access to the encoded information, " said Dr Patrick Reilly, a Senior Scientist at NCCS. Errors in chromatin structure are found in a wide array of developmental diseases as well as in all types of cancers. By understanding the processes controlling chromatin structure, we hope to improve our tools for timely regulation of specific genes, thus reversing the impact of many diseases and developing novel anti-cancer agents.

In recent decades, scientists have found that proper regulation of genes depends, in part, on these structures. In the study, the researchers in France began studying a specific component of chromatin called H2A.Z, which has been previously shown as important in controlling specific regions of DNA expression. They found that ANP32E, a protein that Dr. Reilly has been studying at NCCS for several years, had the ability to strip H2A.Z away from DNA, thus allowing altered gene expression. In collaboration, Dr Reilly was able to provide a mouse, which he generated to specifically lack ANP32E and together they found that cells lacking ANP32E lacked the proper chromatin structure. Since Dr Reilly is studying ANP32E as a possible therapeutic target based on its unusual protein composition, this finding could reveal novel therapeutic strategies in the long run.


'/>"/>

Contact: Ms Rachel Tan
Rachel.Tan.C.H@nccs.com.sg
659-754-0842
SingHealth
Source:Eurekalert

Related medicine news :

1. Scientists make your stomach turn bright green if you have an ulcer
2. Scientists reduce protein crystal damage, improve pharmaceutical development
3. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
4. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
5. Scientists discover that short-term energy deficits increase factors related to muscle degradation
6. CNIO scientists create the first large catalog of interactions between drugs and proteins
7. Over 70 new centers to train tomorrows engineers and scientists
8. Scientists Agree: Sleep Less, Get Fat
9. UNC scientists find potential cause for deadly breast cancer relapse
10. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
11. Scientists show how cells protect their DNA from catastrophic damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial Services, ... preparation services, is providing an update on a charitable event that began earlier ... is a locally recognized nonprofit that provides shelter and care for animals seeking ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family ... next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. ... 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... SAN LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... with Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for ... mean is the 90-day elimination period, when the family pays for care, is often ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... Fla. , Oct. 2, 2017  AllianceRx Walgreens ... company formed by Walgreens and pharmacy benefit manager Prime ... its new brand, which included the unveiling of new ... , as well as at a few other ... the new brand to patients, some of whom will ...
Breaking Medicine Technology: