Navigation Links
NCCS scientists discover gene regulation is dependent on protein ANP32E
Date:1/23/2014

Singapore, 23 January 2014 A team of scientists from the National Cancer Centre Singapore (NCCS), the Institut de Gntique et de Biologie Moleculaire et Cellulaire (Strassbourg France), and the Institut Albert Bonniot (Grenoble, France) have made an important finding on how genes are regulated. This study will be released in the January 30th, 2014 print issue of the journal Nature. The discovery used a genetically modified mouse that was developed by Dr Patrick Reilly, a Senior Scientist in the Laboratory of Inflammation Biology headed by Prof Tak Wah Mak at the NCCS, to demonstrate that the architecture of DNA in the living cell is maintained in part by a protein called ANP32E. The ANP32E or Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein in humans.

"While DNA is normally represented as a two strands forming a helix, the actual amounts of DNA in the cell mean that these strands must be compacted into complex structures, called chromatin, which restricts the DNA volume while still allowing access to the encoded information, " said Dr Patrick Reilly, a Senior Scientist at NCCS. Errors in chromatin structure are found in a wide array of developmental diseases as well as in all types of cancers. By understanding the processes controlling chromatin structure, we hope to improve our tools for timely regulation of specific genes, thus reversing the impact of many diseases and developing novel anti-cancer agents.

In recent decades, scientists have found that proper regulation of genes depends, in part, on these structures. In the study, the researchers in France began studying a specific component of chromatin called H2A.Z, which has been previously shown as important in controlling specific regions of DNA expression. They found that ANP32E, a protein that Dr. Reilly has been studying at NCCS for several years, had the ability to strip H2A.Z away from DNA, thus allowing altered gene expression. In collaboration, Dr Reilly was able to provide a mouse, which he generated to specifically lack ANP32E and together they found that cells lacking ANP32E lacked the proper chromatin structure. Since Dr Reilly is studying ANP32E as a possible therapeutic target based on its unusual protein composition, this finding could reveal novel therapeutic strategies in the long run.


'/>"/>

Contact: Ms Rachel Tan
Rachel.Tan.C.H@nccs.com.sg
659-754-0842
SingHealth
Source:Eurekalert

Related medicine news :

1. Scientists make your stomach turn bright green if you have an ulcer
2. Scientists reduce protein crystal damage, improve pharmaceutical development
3. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
4. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
5. Scientists discover that short-term energy deficits increase factors related to muscle degradation
6. CNIO scientists create the first large catalog of interactions between drugs and proteins
7. Over 70 new centers to train tomorrows engineers and scientists
8. Scientists Agree: Sleep Less, Get Fat
9. UNC scientists find potential cause for deadly breast cancer relapse
10. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
11. Scientists show how cells protect their DNA from catastrophic damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... San Francisco, CA (PRWEB) , ... May 26, 2016 , ... ... 1st, 2016, from 6pm to 7.30pm PST at HP in Palo Alto, CA. This ... panel discussion will be led by clinical trial experts from the pharmaceutical company Hallux, ...
(Date:5/25/2016)... ... May 25, 2016 , ... “We are ... Partner at HealthScape Advisors. “Brad brings significant experience advising healthcare provider clients throughout ... accelerates with the implementation of MACRA, we believe that continuing to add professionals ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... The Georgia ... Award of Excellence from the Atlanta Urban Design Commission. , The annual award recognizes ... city of Atlanta’s built environment, the preservation of its physical heritage and the balance ...
(Date:5/25/2016)... ... 2016 , ... Serenity Recovery, a holistic treatment center for ... the many supplemental program options offered at their rehabilitation facility, this time focusing ... Belt in the Shorin-ryu style of Karate that originated in Okinawa, Japan, and ...
(Date:5/25/2016)... ... ... to an article published May 5th on The Daily Mail, a survey pointed ... it found that more than a third cited unappealing breath a one of their top ... a failure to brush after meals, can typically be attributed to gum disease. Moreover, the ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25,2016 ... the near-infrared Cellvizio platform for urological and surgical ... OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary confocal ... regulatory milestone in the US with the 12 ... and Drug Administration (FDA). This new FDA clearance ...
(Date:5/25/2016)... India , May 25, 2016 ... Animation Market by Type (3D, 2D, 4D), by Therapeutic ... Education), by End User (Medical Device Manufacturers, Hospitals/ Clinics) ... studies the global Medical Animation Market for the forecast ... to reach USD 301.3 Million by 2021 from USD ...
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 /PRNewswire/ ... dringenden Bedarf zur Steuerung ... N.V. (NASDAQ: QGEN ; Frankfurt Prime ... Entwicklungsvereinbarung mit Therawis Diagnostics GmbH zur Entwicklung und ... sein. Ein erstes Projekt wird die Entwicklung und ...
Breaking Medicine Technology: