Navigation Links
NCCS scientists discover gene regulation is dependent on protein ANP32E
Date:1/23/2014

Singapore, 23 January 2014 A team of scientists from the National Cancer Centre Singapore (NCCS), the Institut de Gntique et de Biologie Moleculaire et Cellulaire (Strassbourg France), and the Institut Albert Bonniot (Grenoble, France) have made an important finding on how genes are regulated. This study will be released in the January 30th, 2014 print issue of the journal Nature. The discovery used a genetically modified mouse that was developed by Dr Patrick Reilly, a Senior Scientist in the Laboratory of Inflammation Biology headed by Prof Tak Wah Mak at the NCCS, to demonstrate that the architecture of DNA in the living cell is maintained in part by a protein called ANP32E. The ANP32E or Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein in humans.

"While DNA is normally represented as a two strands forming a helix, the actual amounts of DNA in the cell mean that these strands must be compacted into complex structures, called chromatin, which restricts the DNA volume while still allowing access to the encoded information, " said Dr Patrick Reilly, a Senior Scientist at NCCS. Errors in chromatin structure are found in a wide array of developmental diseases as well as in all types of cancers. By understanding the processes controlling chromatin structure, we hope to improve our tools for timely regulation of specific genes, thus reversing the impact of many diseases and developing novel anti-cancer agents.

In recent decades, scientists have found that proper regulation of genes depends, in part, on these structures. In the study, the researchers in France began studying a specific component of chromatin called H2A.Z, which has been previously shown as important in controlling specific regions of DNA expression. They found that ANP32E, a protein that Dr. Reilly has been studying at NCCS for several years, had the ability to strip H2A.Z away from DNA, thus allowing altered gene expression. In collaboration, Dr Reilly was able to provide a mouse, which he generated to specifically lack ANP32E and together they found that cells lacking ANP32E lacked the proper chromatin structure. Since Dr Reilly is studying ANP32E as a possible therapeutic target based on its unusual protein composition, this finding could reveal novel therapeutic strategies in the long run.


'/>"/>

Contact: Ms Rachel Tan
Rachel.Tan.C.H@nccs.com.sg
659-754-0842
SingHealth
Source:Eurekalert

Related medicine news :

1. Scientists make your stomach turn bright green if you have an ulcer
2. Scientists reduce protein crystal damage, improve pharmaceutical development
3. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
4. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
5. Scientists discover that short-term energy deficits increase factors related to muscle degradation
6. CNIO scientists create the first large catalog of interactions between drugs and proteins
7. Over 70 new centers to train tomorrows engineers and scientists
8. Scientists Agree: Sleep Less, Get Fat
9. UNC scientists find potential cause for deadly breast cancer relapse
10. Western University cancer researcher teams up with Chinese scientists to study chemotherapy
11. Scientists show how cells protect their DNA from catastrophic damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... Dallas, Texas (PRWEB) , ... June 24, 2016 ... ... 12th International Conference and Scientific Sessions in Dallas that it will receive two ... Announcement of the grants came as PHA marked its 25th anniversary by recognizing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
Breaking Medicine Technology: