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NCCN Stresses Importance of PSA Testing in High-Risk Men
Date:8/10/2009

r early in high-risk men, not the screening of mass populations. The updated NCCN Guidelines emphasize this point with a note in the introduction stating that they are specifically for men opting to participate in an early detection program after receiving appropriate counsel.

An additional update to the NCCN Guidelines is a higher PSA (1.0 ng/mL) that would prompt high-risk men to receive more frequent screenings. Therefore, the current NCCN Guidelines recommend that at age 40, high-risk men be offered a baseline PSA and DRE and if their PSA is 1.0 ng/mL or greater, that they receive annual follow-ups. If their PSA is less than 1.0, the NCCN Guidelines recommend that these men be screened again at age 45.

The NCCN Guidelines for Prostate Cancer Early Detection do not include information on the treatment of prostate cancer; treatment recommendations are available in the NCCN Guidelines for Prostate Cancer. The NCCN Guidelines for Prostate Cancer are continuously updated and have increasingly emphasized the assessment of life expectancy, the threat to the life of the patient posed by prostate cancer, and enhanced the sections with the option of active surveillance.

In conclusion, the NCCN Guideline Panel Members acknowledge that there is no "right" answer about PSA testing for everyone, but that each man needs to make an informed decision with his physician.

NCCN Clinical Practice Guidelines in Oncology(TM) are developed and updated through an evidence-based process with explicit review of the scientific evidence integrated with expert judgment by multidisciplinary panels of physicians from NCCN Member Institutions. The most recent version of this and all the NCCN Guidelines are available free of charge at NCCN.org.

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SOURCE National Comprehensive Cancer Network
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