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NCCN Receives $4 Million Oncology Research Grant from Wyeth
Date:1/15/2009

gical process that is a fundamental step in the transition of tumors from a dormant state to a malignant state. By disrupting this pathway, temsirolimus may inhibit the growth of tumors.

"This collaboration represents a unique opportunity to benefit from the research expertise of NCCN and their Member Institutions as we explore the potential of Torisel in the treatment of a variety of solid tumors," says Mikael Dolsten, President, Research and Development, Wyeth Pharmaceuticals. "We are pleased to support an organization that shares our commitment to innovative cancer research to the benefit of patients with cancer."

The primary goal of clinical trials resulting from this grant is to help determine the role of temsirolimus in the treatment of solid tumors in a variety of cancers. Significant secondary goals include:

  • Identification of cancers or cancer subtypes that may be dependent on the mTOR pathway.
  • Clarification of the mechanism of action of mTOR inhibition in different tumors.
  • Investigation of combination therapy with cytotoxics, targeted therapies, biologic agents, and radiation therapy, based on hypothesis generating preclinical studies.
  • Identification of biomarkers and molecular imaging that can be used to assess mTOR inhibition.

The NCCN Oncology Research Program (ORP) facilitates all phases of clinical research by identifying clinical investigators and initiating trials at NCCN Member Institutions. The ORP draws on the expertise of investigators at 21 of the world's leading cancer centers and establishes collaborations with pharmaceutical and biotech companies in order to advance therapeutic options for patients with cancer.

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network (NCCN), a not-for-profit alliance of 21 of th
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SOURCE National Comprehensive Cancer Network
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