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NCCN Receives $4 Million Oncology Research Grant from Wyeth
Date:1/15/2009

NCCN recently received a $4 million research grant from Wyeth Pharmaceuticals to evaluate the safety and effectiveness of temsirolimus in the treatment of solid tumors. Temsirolimus is currently approved to treat advanced renal cell carcinoma (RCC). This grant is the largest research award received by NCCN to date. Investigators from NCCN Member Institutions are eligible to apply for the research funding.

FORT WASHINGTON, Pa., Jan. 15 /PRNewswire-USNewswire/ -- The National Comprehensive Cancer Network (NCCN) has been awarded a $4 million grant from Wyeth Pharmaceuticals to support clinical studies of temsirolimus (Torisel(R), Wyeth) in the treatment of solid tumors. This is the largest individual research grant that NCCN has received since the inception of its Oncology Research Program in 1999.

Temsirolimus is a targeted therapy approved to treat advanced renal cell carcinoma (RCC), a type of cancer that originates in the kidney. Clinical trials supported by this grant will evaluate the effectiveness of temsirolimus in solid tumors, including but not limited to, breast, endometrial, head and neck, hepatocellular, hormone-refractory prostate, non-small cell lung, and ovarian cancers.

"This grant represents the largest research award to date for NCCN and is an outstanding achievement," says William T. McGivney, PhD, Chief Executive Officer, NCCN. "The funding not only helps accelerate potentially life-saving research in the field of cancer, but also creates a collaborative opportunity for investigators from NCCN Member Institutions. Obtaining major research grants represents yet another way in which NCCN lives out our mission of improving the quality and effectiveness of care provided to patients with cancer."

Temsirolimus is the only commercially available inhibitor of mammalian target of rapamycin (mTOR). The mTOR signaling pathway regulates cell growth and promotes angiogenesis, a physiolo
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SOURCE National Comprehensive Cancer Network
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