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NCCN Guidelines for Non-Small Cell Lung Cancer Updated to Incorporate Maintenance Therapy
Date:12/9/2009

NCCN updates the NCCN Guidelines for Non-Small Cell Lung Cancer to include guidance on maintenance therapy, several new therapeutic recommendations for specific patients with Non-Small Cell Lung Cancer, and a revised staging system.

FORT WASHINGTON, Pa., Dec. 9 /PRNewswire-USNewswire/ -- The National Comprehensive Cancer Network (NCCN) recently updated the NCCN Guidelines for Non-Small Cell Lung Cancer (NSCLC) to incorporate a new section about maintenance therapy, a number of new indications for specific therapies for advanced NSCLC, and the recently revised staging system for lung cancer. Lung cancer remains the leading cause of cancer death in the United States.

The updated NCCN Guidelines now include a description of maintenance therapy for patients with advanced or metastatic disease. Maintenance therapy refers to treatment that prevents a cancer from spreading after it has responded to initial treatments with chemotherapy (usually 4 to 6 rounds of treatment). This new section helps distinguish between recommended therapies for continuation maintenance versus switch maintenance.

Noteworthy updates to the NCCN Guidelines involving specific therapies for advanced NSCLC include:

  • The addition of erlotinib (Tarceva(R), Genentech BioOncology and OSI Oncology) as a first-line treatment option for EGFR mutation positive patients with advanced or metastatic disease.
  • Bevacizumab (Avastin(TM), Genentech BioOncology) and cetuximab (Erbitux(R), Bristol-Myers Squibb Company and ImClone Systems Incorporated) have been added as treatment options for continuation maintenance with a category 1 designation.
  • Pemetrexed (Alimta(R), Eli Lilly & Company) and erlotinib have been added as treatment options for switch maintenance with a category 2B designation and docetaxel (Taxotere(R), sanofi-aventis, U.S.) has been added with a category
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SOURCE National Comprehensive Cancer Network
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