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NCCN Announces Updates to Pancreatic Adenocarcinoma Guidelines
Date:3/13/2009

ised set of criteria based on a consensus of the panel members which defines borderline resectable disease.

Dr. Tempero also provided additional clarification regarding the importance of upfront systemic therapy prior to administration of chemoradiation therapy stating that, "Radiation is important for a subset of patients with local disease only, but systemic chemotherapy should be given first."

Upfront systemic therapy provides for disease control and allows selection of those patients most likely to benefit from subsequent chemoradiation.

Dr. Tempero also recommended fluorinated pyrimidine-based therapy with oxaliplatin (Eloxatin(R), sanofi-aventis) as a second-line option for patients with advanced disease and good performance status based on results of clinical trial that showed a significant survival benefit for patients receiving the combination of therapies.

Dr. Tempero summarized the recommendations for patients with metastatic disease by saying, "Single agent gemcitabine (Gemzar(R), Eli Lilly and Company) or selected gemcitabine combinations followed by a fluorinated pyrimidine plus oxaliplatin is the standard of care."

Of all the gastrointestinal malignancies, pancreatic adenocarcinoma is the second most common cause of death from cancer. The diagnosis of pancreatic cancer is rarely made at an early stage, which is one of the main reasons for failing to achieve a cure in most patients.

Dr. Tempero illustrated this point further during the presentation stating that, "80 percent of patients with pancreatic cancer relapse systematically even with adjuvant therapy" and that "clinicians must keep this in mind as we treat our patients."

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network (NCCN), a not-for-profit alliance of 21 of the world's leading cancer centers, is dedicated to improvin
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SOURCE National Comprehensive Cancer Network
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