Navigation Links
Mysterious fevers of unknown origin: Could surgery be a cure?
Date:3/28/2008

A child spikes a high fever, sometimes as high as 104 or 105 degrees, and sometimes causing seizures. Shes rushed to the emergency room, the hospital runs test after test, specialists are brought in, but no explanation is found.

Many families though no one knows how many go through this cyclical nightmare. The fevers seem to come like clockwork, arent accompanied by any obvious symptoms and dont respond to antibiotics or fever reducers like Motrin or Tylenol. Instead, they vanish on their own after four to five days, only to return four to six weeks later.

A report in last months Archives of Otolaryngology and Head and Neck Surgery finds that tonsillectomy (with or without removal of the adenoids) is almost always curative. No one knows why the tonsils and adenoids show no evidence of unusual infection or other abnormality when pathologists study them. But desperate families are opting for surgery as a last-ditch measure and finding it to be life-changing.

The paper, describing 27 children treated at Childrens Hospital Boston from 2004 through 2006, offers the largest reported surgical experience to date with this syndrome, currently known as PFAFA (periodic fever, aphthous ulcers, pharyngitis and adenitis). Of the 27 children, 26 had complete fever resolution. Many had suffered cyclical fevers for years.

Why taking out tonsils and adenoids works is unclear, but it works in almost every single kid, says Childrens otolaryngologist Greg Licameli, MD, FACS, the papers first author. I tell parents, I dont know why this works, but it has a good chance of ridding your child of fevers.

Licameli has now seen 60 children with PFAFA, first described in the medical literature in 1987, and the findings continue to hold up. Given how many children hes seen in just five years, he thinks the condition isnt all that uncommon, though it is underrecognized and unknown to most pediatricians and otolaryngologists.

Licamelis introduction to PFAFA was a personal one: His first patient, described as a case report in the paper, was his own daughter, who at 19 months was getting fevers every three weeks. There was nothing to break the fevers, he recalls. She was seen by several experts at Childrens. The workup was always negative.

Searching the medical literature for answers, Licameli found two small case studies in Europe, where doctors diagnosed PFAPA, removed the tonsils and the children got better, and decided to try this approach. It worked, with an immediate cessation of his daughters fever cycles (shes now almost 6), and other doctors began referring patients to him.

The hallmark of PFAFA is high fevers of a cyclical nature parents can often look at their calendars and predict what day the fevers will arrive. There are typically no other symptoms. Some children have sore throat, swollen glands and small mouth ulcers, but these symptoms arent very specific and can be very subtle.

On the face of it, it doesnt seem like a surgical problem, Licameli says. The tonsils and adenoids appear normal, even when you study them pathologically, yet surgery is immediately curative.

Before undergoing surgery, patients are evaluated for any rheumatologic or infectious etiologies that can also cause cyclical fever.

So what causes this condition, and why does surgery work? Licameli suspects the tonsils may harbor a chronic indolent infection to which the immune system is hypersensitive. He and his colleagues at Childrens including specialists in infectious disease, rheumatology and immunology -- plan to pursue these questions further.

In the meantime, they hope that increased physician awareness will allow children struggling with this condition to be offered surgery sooner.


'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Related medicine news :

1. Deafness and seizures result when mysterious protein deleted in mice
2. Methamphetamine Use Associated With Pulmonary Arterial Hypertension in Patients With Previously Unknown Risk Factors
3. Study provides hope that some transplant patients could live free of antirejection drugs
4. Study provides hope that some transplant patients could live free of anti-rejection drugs
5. HIV denialists spread misinformation online -- consequences could be deadly; and more
6. Virus Could Help Drive Obesity
7. Discovery of sugar sensor in intestine could benefit diabetes
8. Cranberry Could Juice Up Ovarian Cancer Treatment
9. Treating Diabetes During Pregnancy Could Lead to Thinner Kids
10. High-risk behaviors could lead to HIV epidemic in Afghanistan
11. Chinas 1-child policy could backfire on its elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Pets bring laughter, joy and ... appreciation, pet owners celebrate National Pet Week, which falls on the first full week ... owners to cherish the human-animal bond and recognize responsible pet ownership. Pet owners can ...
(Date:5/2/2016)... ... May 02, 2016 , ... The Civilian Corps of the U.S. Army Medical ... that care for its uniformed service members, the retired service members, their families and ... 6th through May 12th National Nurses Week. It acknowledges the hard work and dedication ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... help consumers better understand life insurance throughout various life stages. , The site ... life insurance needs calculator and content specific to the times when life insurance ...
(Date:5/2/2016)... ... May 02, 2016 , ... In honor of National Physical ... incentive to people who share their fitness journey on social media. , The ... products, will award a $100 product voucher each week during May to one winner. ...
(Date:5/2/2016)... ... , ... WestHarbor Growth Partners, a growth, expansion and turnaround ... Healthy Vending’s newly revamped brand campaign. Grow Healthy Vending is headquartered in ... North America with locations across the United States as well as internationally. ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... BERLIN , April 29, 2016 ... world-leading glyco-biology expertise, today announces the appointment of Dr. ... Dr. Zurlo is an oncologist with many years ... pharmaceutical and biotechnology industries. His last role was at ... Member of the Executive Board. Previously Dr. Zurlo held ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s ... complement the company,s valve repair and stent business, ... also places Abbott more firmly into patient monitoring.  ... the fastest growing device areas, with double-digit growth ... recent report,  Advanced Remote Patient Monitoring ...
(Date:4/28/2016)... April 28, 2016 ... George Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter ... heute bekannt, dass neue Führungskräfte zum Team ... sind, die vielfältige Erfahrungen mitbringen.  Dies wird ...
Breaking Medicine Technology: