Navigation Links
Mysterious cells may play role in ALS
Date:11/17/2010

By tracking the fate of a group of immature cells that persist in the adult brain and spinal cord, Johns Hopkins researchers discovered in mice that these cells undergo dramatic changes in ALS, also known as Lou Gehrig's disease.

A study reported November 17 online in Neuron shows that these cells, called NG2+, grow and expand rapidly during early life, eventually morphing into mature nervous system cells called oligodendrocytes. These "oligos" help speed the transmission of electrical impulses by providing insulation around nerve cells. This insulation, known as myelin, is disrupted in nervous system diseases such as multiple sclerosis.

The team tracked the fate of NG2+ cells in both normal mice and mice with a mutant form of the SOD1 gene that causes ALS. Using a stringent system that let them color-tag only NG2+ cells and then accurately locate these cells at various times in their development, the researchers found that NG2+ cells normally keep up a quiet program of dividing in adult tissues, sometimes replacing themselves and other times forming new oligos.

A slow and steady turnover of oligodendrocytes may be required throughout life to maintain myelin, says Dwight Bergles, Ph.D., associate professor in The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine. However, the normal developmental program of NG2+ cells goes awry in the spinal cords of ALS mice.

"In the model ALS mice we studied, it's as though NG2+ cells step onto a high-speed treadmill," Bergles says. "They undergo explosive division, morph more readily into abnormal-looking oligodendrocytes and then, uncharacteristically, those differentiated cells quickly die. The brakes that normally hold these cells in check appear to be gone in ALS."

Of special note are provocative data showing this cell type as the most proliferating cell population in the spinal cords of ALS mice, churning out even more oligodendrocyt
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Mysterious ball lightning: Illusion or reality?
2. Scientists discover the mechanisms and function of a type of mysterious immune cell
3. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
4. New study suggests stem cells sabotage their own DNA to produce new tissues
5. Attacking cancer cells with hydrogel nanoparticles
6. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
7. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
8. New tool illuminates connections between stem cells and cancer
9. Bitter melon extract attacks breast cancer cells
10. Heart Stem Cells Move Closer to Human Treatments
11. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... (PRWEB) November 24, 2014 Abington ... Ternopolska, MD has joined The Neurology Group and ... Multiple Sclerosis Center. , A graduate of Vinnica ... Neurology at Albert Einstein Medical Center in Philadelphia and ... Jaffe Multiple Sclerosis Center at Weill Cornell Medical College. ...
(Date:11/24/2014)... 24, 2014 Recently, SweetDressy.com, a well-known ... its new collection of 2014 Evening Dresses. All these ... to the company’s marketing manager, the special offer is ... for more. , Sweetdressy.com has been working well in ... unveil the latest designs. Their new dresses may be ...
(Date:11/24/2014)... The typical American diet includes foods that ... consuming a diet high in calories and carbohydrates only ... that typically accumulate around the internal organs exposing people ... in the form of love handles, beer bellies and ... to rid themselves of the burden of embarrassing, unhealthy ...
(Date:11/24/2014)... California (PRWEB) November 24, 2014 Dr. ... Diego Fertility Center, recently appeared on NBC to discuss egg ... Egg freezing has been trending in the news recently, with ... expensive procedure for women. , “[The companies] see ... who are on a career hot path.” Says Dr. Kettel. ...
(Date:11/23/2014)... the coming special Friday, Tidebuy, a famous wedding dress ... many products, especially the beautiful colored wedding dresses ( ... amazing discounts, up to 90% off. Don’t hesitate to ... to buy colored wedding dresses in different sizes and ... for delicate craftsmanship, elegant style and perfect lines. All ...
Breaking Medicine News(10 mins):Health News:Nataliya Ternopolska Named Associate Medical Director of Abington Health’s Multiple Sclerosis Center 2Health News:SweetDressy.com Unveiled A New Selection Of Evening Dresses 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Beautiful Wedding Dresses Available at Popular B2C Company Tidebuy 2
... 4 The American,College of Pediatricians challenges the results ... recently released by Murray Straus, a,leading opponent of the ... to sexual problems in teens and adults is premature ... investigation to the common,use of ordinary spanking by loving ...
... Designed to Tackle Taste Barrier to ... Vegetable Consumption, CAMDEN, N.J., March ... makers of V8(R) juices are rolling,out a new 100% juice blend with ... Acai berry. V8 V-Fusion(R) Acai Mixed Berry,juice provides a full serving of ...
... Programs to Gain Members, ... from HealthLeaders-InterStudy, NASHVILLE, Tenn., March 4 ... that San,Antonio employers, predominantly small businesses with less ... their health insurance premiums,down with participation in wellness ...
... to Help Hospitals Prevent Infections, DUBLIN, Ohio, ... products and services that improve the safety and,productivity ... to,acquire the assets of privately held Enturia Inc. ... line of infection prevention,products sold under the ChloraPrep(R) ...
... March 4 Therap Services, a service,bureau ... to,organizations working with people with developmental disabilities,announces ... Project Manager. Mozammel,will have the primary responsibility ... "Mozammel has made remarkable contributions to ...
... 4 Crdentia Corp. (OTC Bulletin,Board: CRDT), ... services,today announced the appointment of Mr. Randall ... Chief Clinical Officer. In this newly created,position, ... compliance and accreditation, assisting in business,plan development ...
Cached Medicine News:Health News:American College of Pediatricians Questions Validity of Spanking Study 2Health News:V8 V-Fusion(R) Takes an Exotic, Tasty Twist on Vegetable Juice 2Health News:San Antonio Employers Look to Wellness Programs to Tackle Rising Health Insurance Premiums 2Health News:Cardinal Health Agrees to Acquire ChloraPrep(R) Manufacturer for $490 Million 2Health News:Cardinal Health Agrees to Acquire ChloraPrep(R) Manufacturer for $490 Million 3Health News:Cardinal Health Agrees to Acquire ChloraPrep(R) Manufacturer for $490 Million 4Health News:Cardinal Health Agrees to Acquire ChloraPrep(R) Manufacturer for $490 Million 5Health News:Cardinal Health Agrees to Acquire ChloraPrep(R) Manufacturer for $490 Million 6Health News:Therap Services Promotes Mozammel Haque to Project Manager 2Health News:Crdentia Appoints Randall Turnbull to Senior Vice President and Chief Clinical Officer 2Health News:Crdentia Appoints Randall Turnbull to Senior Vice President and Chief Clinical Officer 3
(Date:11/23/2014)... , Nov. 23, 2014  Aurobindo Pharma ... of Gabapentin Capsules, USP 300 mg 100-count bottles to ... to contain some empty capsules. Empty capsules ... adverse health consequences that could range from no effect, ... or status epilepticus (long period seizures) that could be ...
(Date:11/22/2014)... -- New data demonstrates that flibanserin, a novel, non-hormonal medicine ... sexual dysfunction, Hypoactive Sexual Desire Disorder (HSDD), does not ... women when taken at bedtime. The data was presented ... America,s (SMSNA) 20th Annual Fall Scientific Meeting ... SMSNA accepted this study as a late breaking abstract ...
(Date:11/22/2014)... , 21 de noviembre de 2014  BioClinica®, ... clínicos externalizados y tecnologías eClinical, ha indicado un ... ,seguimiento inteligente, para el seguimiento basado en el ... amplía el concepto del seguimiento basado en el ... las visitas de seguimiento o cambio de los ...
Breaking Medicine Technology:Aurobindo Pharma USA, Inc. Issues Voluntary Nationwide Recall of Northstar Label Gabapentin Capsules, USP 300 mg Due to Complaints of Empty Capsules 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 3El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3
... Today Novo Nordisk announced results of its ... treatment with NovoLog® (insulin aspart [rDNA origin] injection). The ... Scientific Sessions, demonstrated a reduction of A1c levels in ... was introduced at meals, using two approaches that start ...
... Reportlinker.com announces that a new market research report is available in its catalogue: , ... Global Melanoma Therapeutics industry , ... http://www.reportlinker.com/p0197206/Global-Melanoma-Therapeutics-industry.html , , , ... markets for Melanoma Therapeutics in US$ Million. The report provides separate comprehensive analytics for US, ...
Cached Medicine Technology:Study Shows Gradual Addition of NovoLog® at Mealtime Can Reduce A1c in Type 2 Diabetes Patients 2Study Shows Gradual Addition of NovoLog® at Mealtime Can Reduce A1c in Type 2 Diabetes Patients 3Study Shows Gradual Addition of NovoLog® at Mealtime Can Reduce A1c in Type 2 Diabetes Patients 4Study Shows Gradual Addition of NovoLog® at Mealtime Can Reduce A1c in Type 2 Diabetes Patients 5Study Shows Gradual Addition of NovoLog® at Mealtime Can Reduce A1c in Type 2 Diabetes Patients 6Global Melanoma Therapeutics Industry 2Global Melanoma Therapeutics Industry 3Global Melanoma Therapeutics Industry 4Global Melanoma Therapeutics Industry 5Global Melanoma Therapeutics Industry 6Global Melanoma Therapeutics Industry 7Global Melanoma Therapeutics Industry 8Global Melanoma Therapeutics Industry 9Global Melanoma Therapeutics Industry 10Global Melanoma Therapeutics Industry 11Global Melanoma Therapeutics Industry 12
... for the precise requirements of blood ... Blood Bank Equipment meets American Association ... Red Cross (ANRC) and U.S. Food ... storage freezers, and platelet incubators feature ...
... Designed for the precise requirements ... Thermo Forma Blood Bank Equipment meets ... American National Red Cross (ANRC) and ... standards. Refrigerators, storage freezers, and platelet ...
Refrigerator specially designed for the storage of blood in standard 500ml bags, complying with Australian Standard AS3864 1997....
The Testosterone Enzyme Immunoassay is intended for the quantitative determination of Testosterone concentration in human serum. No special pretreatment of the sample is necessary. For in vitro Diag...
Medicine Products: