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Myriad publishes clinical utility study for Prolaris
Date:3/3/2014

in Therapeutic Burden Among Trial Participants

Number of Patients in the Study Number of Patients Who Saw an Increase in Therapeutic Burden Percentage Increase in Therapeutic Burden
305 76 +25%

The study also evaluated the shift in treatment paradigms from interventional to non-interventional and non-interventional to interventional. Those data appear in the Table-3 and Table-4 below:

Table 3: Planned Interventional Therapy (e.g., Surgery and/or Radiation)

Number of Patients Planned for Interventional Treatment Before Prolaris Test Score Number of Patients Planned for Interventional Treatment After Prolaris Test Score Percentage Decrease in Interventional Therapy
164 103 -37%

Table 4: Planned Non-Interventional Therapy (e.g., Active Surveillance and/or Watchful Waiting)

Number of Patients Planned for Non-Interventional Treatment Before Prolaris Test Score Number of Patients Planned for Non-Interventional Treatment After Prolaris Test Score1 Percentage Increase in Interventional Therapy
141 108 +23%

Importantly, in this study there was an overall 50 percent reduction in surgical interventions and a 30 percent reduction in radiation treatment. Additionally, 96 percent of the 24 patients with initial "undecided" treatment regimens selected non-interventional options after receiving the Prolaris score. These results demonstrate that the Prolaris test is associated with high clinical utility among urologists.

"In multiple clinical studies, Prolaris was shown to provide personalized risk of cancer-spe
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Contact: Ronald Rogers
rrogers@myriad.com
801-584-3065
Myriad Genetics, Inc.
Source:Eurekalert

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