Navigation Links
MyoD helps stem cells proliferate in response to muscle injury

The master regulator of muscle differentiation, MyoD, functions early in myogenesis to help stem cells proliferate in response to muscle injury, according to researchers at Case Western Reserve University. The study appears online Jan. 4 in the Journal of Cell Biology (

MyoD is a transcription factor that activates muscle-specific genes as myoblast precursors differentiate and fuse to form mature muscle fibers. But MyoD is also expressed at an earlier stage of myogenesis when quiescent stem cells rapidly expand in number to generate the myoblasts needed to repair tissue damage. The transcription factor's function in this proliferative phase is unknown.

The team found that MyoD bound to the promoter of CDC6, a gene that initiates DNA replication, suggesting that MyoD might activate Cdc6 expression in muscle stem cells to promote their reentry into the cell cycle and rapid proliferation. Indeed, Cdc6 was expressed shortly after MyoD in stimulated muscle progenitors, and knocking down MyoD reduced Cdc6 production and slowed cells' entry into S phase. MyoD works in conjunction with transcription factors from the E2F family. E2F3a activated the CDC6 promoter with MyoD, but was replaced by the repressive family member E2F4 as myoblasts began to differentiate.

Senior author Nikki Harter now wants to investigate how the transcription factors cooperate to control Cdc6 expres-sioninitial results suggest that MyoD recruits E2F3a to the promoter region. The researchers also propose that a related protein, Myf5, might control Cdc6 transcription in MyoD's absence, acting as a backup mechanism to ensure that muscle stem cells expand to repair tissue damage.


Contact: Rita Sullivan
Rockefeller University Press

Page: 1

Related medicine news :

1. Bariatric Advantage Helps Bariatric Patients to Remember Their Surgeons Nutritional Protocols!
2. Metabolife(R) Helps People Nationwide Start off the New Year Right as the Presenting Sponsor of the 2009 Brian Boitano Skating Spectacular
3. Placebo Effect Helps Some Psoriasis Patients
4. Narconon Helps Restore Honesty and Trust to Former Addicts
5. Flipping for Phonics(TM) Helps Spread Cheer To Military Families In Fisher Houses(R) This Holiday Season
6. Patent Granted on GenerOs EX, A Medical Device That Helps Bones Grow
7. Who Should Deliver Your Baby? New Tool Helps Expectant Parents Choose Their Health Care Provider
8. Bullfrog Spas Helps Critically Ill Children
9. New Website Helps Grocers Comply With COOL Laws
10. 4Rs Profit Optimizing Inventory Solutions Helps The Vitamin Shoppe Drive Increased Productivity and Performance
11. Free Webinar Series at Shows How New Combination Liposuction/Fat Transfer Treatment Helps Patients Slim Down and Reduce Facial Wrinkling
Post Your Comments:
Related Image:
MyoD helps stem cells proliferate in response to muscle injury
(Date:11/30/2015)... (PRWEB) , ... December 01, 2015 , ... The Turks ... Journal, one of the leading digital news sites highlighting Caribbean destinations, has published five ... While much of North America shivers under chilly grey skies or worse, it's ...
(Date:11/30/2015)... ... November 30, 2015 , ... 1Heart Caregiver Services’ Executive Team ... of Philippine American Chambers of Commerce held from November 6-8, 2015 at the ... Services, as an active delegate from the Philippine American Chamber of Commerce of ...
(Date:11/30/2015)... ... November 30, 2015 , ... During ... information for caregivers and held two webinars on topics of ‘Medical and Palliative ... of charge at . , With a loved one's diagnosis of ...
(Date:11/30/2015)... Minneapolis, MN (PRWEB) , ... November 30, 2015 ... ... launched at . The directory is specialized and only includes chiropractic ... is to find a competent and trustworthy alternative health practitioner when back pain ...
(Date:11/30/2015)... ... November 30, 2015 , ... In an ... festivities, the Word of Life Christian Church of Flint, MI, hosted a family-oriented ... giant 1.25 ton pile of candy dubbed “Candy Mountain”. , A Forever Recovery, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Die MEDTEC Japan 2016, ... Entwicklung und Herstellung medizinischer Geräte, findet ... in Tokyo ... Foto: ... --> ...
(Date:11/30/2015)... India , December 1, 2015 /PRNewswire/ ... --> adds "Endometriosis - Pipeline ... provides an overview on therapeutic pipeline of ... to create effective counter strategies to gain ... identifying new targets and MOAs to produce ...
(Date:11/30/2015)... Nevro Corp. (NYSE: NVRO ), a global ... the treatment of chronic pain, today announced that the Patent ... Trademark Office (USPTO) has denied instituting an inter partes ... patent).  --> --> ... filed two petitions challenging the validity of certain claims of ...
Breaking Medicine Technology: