Navigation Links
Myelodysplastic Syndrome Linked to Abnormal Stem Cells
Date:7/5/2012

THURSDAY, July 5 (HealthDay News) -- As researchers suspected, abnormal bone marrow stem cells trigger the development of myelodysplastic syndromes, serious blood diseases that affect the bone marrow and can progress to leukemia, according to a new study.

"Good Morning America" host Robin Roberts recently disclosed that she had developed myelodysplastic syndrome, or MDS, as a rare complication of her breast cancer treatment. The syndrome is diagnosed in about 10,000 to 15,000 people in the United States each year, mostly in men and in those over age 60.

The new findings, published in the July 2 online edition of Blood, could lead to improved treatments for myelodysplastic syndrome and cancers related to the syndrome, researchers from the Albert Einstein College of Medicine of Yeshiva University, in New York City, suggested in an Einstein news release.

"Researchers have suspected that [myelodysplastic syndrome] is a 'stem cell disease,' and now we finally have proof," said the study's co-senior author Amit Verma, an associate professor of medicine and of developmental and molecular biology at Einstein and attending physician in oncology at Montefiore Einstein Center for Cancer Care.

"Equally important, we found that even after [myelodysplastic syndrome] standard treatment, abnormal stem cells persist in the bone marrow. So, although the patient may be in remission, those stem cells don't die and the disease will inevitably return. Based on our findings, it's clear that we need to wipe out the abnormal stem cells in order to improve cure rates," Verma explained in the news release.

For the study, the researchers analyzed bone marrow stem cells and the progenitor cells, or cells formed by stem cells, of 16 patients with various types of myelodysplastic syndrome. They compared these cells to those of 17 people who did not have the syndrome.

The investigators found widespread genetic and epigenetic (related to environmental factors) variations in the stem and progenitor cells taken from myelodysplastic syndrome patients. The abnormalities were more obvious in those with more serious forms of the disease, the researchers noted.

"Our study offers new hope that [myelodysplastic syndromes] can be more effectively treated, with therapies that specifically target genes that are deregulated in early stem and progenitor cells," the study's co-senior author Dr. Ulrich Steidl, an assistant professor of cell biology and of medicine at Einstein, said in the news release. "In addition, our findings could help to detect minimal residual disease in patients in remission, allowing for more individualized treatment strategies that permanently eradicate the disease."

More information

The U.S. National Library of Medicine has more about myelodysplastic syndromes.

-- Mary Elizabeth Dallas

SOURCE: Albert Einstein College of Medicine, news release, July 2, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction, Moffitt says
2. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
3. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
4. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
5. Broken heart syndrome protects the heart from adrenaline overload
6. Antibiotics Linked to Retinal Detachment Risk
7. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
8. Pharmacy Robots Linked to Bacterial Contamination of Drugs
9. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
10. Dental X-Rays May Be Linked to Benign Brain Tumors
11. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Myelodysplastic Syndrome Linked to Abnormal Stem Cells 
(Date:2/8/2016)... ... 2016 , ... Eating disorders and post-traumatic stress disorder (PTSD) ... men with eating disorders report a history of trauma, research suggests that it ... eating disorder. , At the 2016 iaedp Symposium, the workshop, “What Eating ...
(Date:2/8/2016)... Gaithersburg, MD (PRWEB) , ... February 08, 2016 ... ... (AHCC) is excited to share this important news! AHCC and the Home Health ... (AHA) Coding Clinic, CMS' designee for official ICD coding guidance and clarifications, to ...
(Date:2/8/2016)... ... 08, 2016 , ... The schedule is now online for the ... Conference, which is being held May 25-29 at the Loews Chicago O’Hare Hotel, continues ... and causes of chronic illness in children. , Very recent articles have cited 1 ...
(Date:2/7/2016)... ... February 07, 2016 , ... HealthSmart Holdings, Inc. announced ... with the tools and information to lower the costs, and increase the impact ... of providing employee healthcare benefits by as much as 22%:, + Price ...
(Date:2/6/2016)... Viejo, CA (PRWEB) , ... February 06, 2016 , ... ... quickly and easily add warm color grades to their footage. A LUT is a ... every pixel's color to the corresponding color indicated by the table. By manipulating each ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... announced the addition of the "Global ... financials" company profile to their offering. ... announced the addition of the "Global ... financials" company profile to their offering. ...
(Date:2/5/2016)... BEIJING , Feb. 5, 2016 ... ("Dehaier Medical" or the "Company"), which develops, markets ... products in China and ... restructuring plan which aims to concentrate the Company,s ... wearable sleep respiratory business and to focus more ...
(Date:2/5/2016)... 2016 Site Profile: --> ... - The Speech Recognition People, announced their latest primary healthcare case ... care, reduce turnaround times and to save the practice money. ... since 2013 Challenge: --> ,- Wirral CCG ... - Six doctors ,- Wirral CCG ,- VoicePower client since 2013 ...
Breaking Medicine Technology: