Navigation Links
Myelodysplastic Syndrome Linked to Abnormal Stem Cells
Date:7/5/2012

THURSDAY, July 5 (HealthDay News) -- As researchers suspected, abnormal bone marrow stem cells trigger the development of myelodysplastic syndromes, serious blood diseases that affect the bone marrow and can progress to leukemia, according to a new study.

"Good Morning America" host Robin Roberts recently disclosed that she had developed myelodysplastic syndrome, or MDS, as a rare complication of her breast cancer treatment. The syndrome is diagnosed in about 10,000 to 15,000 people in the United States each year, mostly in men and in those over age 60.

The new findings, published in the July 2 online edition of Blood, could lead to improved treatments for myelodysplastic syndrome and cancers related to the syndrome, researchers from the Albert Einstein College of Medicine of Yeshiva University, in New York City, suggested in an Einstein news release.

"Researchers have suspected that [myelodysplastic syndrome] is a 'stem cell disease,' and now we finally have proof," said the study's co-senior author Amit Verma, an associate professor of medicine and of developmental and molecular biology at Einstein and attending physician in oncology at Montefiore Einstein Center for Cancer Care.

"Equally important, we found that even after [myelodysplastic syndrome] standard treatment, abnormal stem cells persist in the bone marrow. So, although the patient may be in remission, those stem cells don't die and the disease will inevitably return. Based on our findings, it's clear that we need to wipe out the abnormal stem cells in order to improve cure rates," Verma explained in the news release.

For the study, the researchers analyzed bone marrow stem cells and the progenitor cells, or cells formed by stem cells, of 16 patients with various types of myelodysplastic syndrome. They compared these cells to those of 17 people who did not have the syndrome.

The investigators found widespread genetic and epigenetic (related to environmental factors) variations in the stem and progenitor cells taken from myelodysplastic syndrome patients. The abnormalities were more obvious in those with more serious forms of the disease, the researchers noted.

"Our study offers new hope that [myelodysplastic syndromes] can be more effectively treated, with therapies that specifically target genes that are deregulated in early stem and progenitor cells," the study's co-senior author Dr. Ulrich Steidl, an assistant professor of cell biology and of medicine at Einstein, said in the news release. "In addition, our findings could help to detect minimal residual disease in patients in remission, allowing for more individualized treatment strategies that permanently eradicate the disease."

More information

The U.S. National Library of Medicine has more about myelodysplastic syndromes.

-- Mary Elizabeth Dallas

SOURCE: Albert Einstein College of Medicine, news release, July 2, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction, Moffitt says
2. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
3. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
4. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
5. Broken heart syndrome protects the heart from adrenaline overload
6. Antibiotics Linked to Retinal Detachment Risk
7. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
8. Pharmacy Robots Linked to Bacterial Contamination of Drugs
9. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
10. Dental X-Rays May Be Linked to Benign Brain Tumors
11. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Myelodysplastic Syndrome Linked to Abnormal Stem Cells 
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding them ... a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to provide ... need to turn on a light when taking medication during the night, allowing the ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... BASKING RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... second annual Holly Day Market. Featuring a collection of specialty vendors and unique items ... myriad of personalized and quality-focused health and wellness services offered by the VNA. ...
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... ... October 12, 2017 , ... First ... compliance program management, will showcase a range of technology and learning solutions at ... (NCAL) Convention and Expo to be held October 14–18, 2017 at the Mandalay ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... to the Centers for Disease Control and Prevention (CDC), influenza vaccination ... is helping communities across Massachusetts , Connecticut ... flu shots through the end of the month. *Some exclusions ... ... shot is by the end of October, according to the Centers for ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
(Date:9/27/2017)... NEW YORK , Sept. 27, 2017  DarioHealth Corp. ... big data solutions, today announced that its MyDario product is expected to ... TV listings for when The Dr. Oz Show airs in your area: ... The nine-time Emmy award-winning, ... ...
Breaking Medicine Technology: