Navigation Links
Myelodysplastic Syndrome Linked to Abnormal Stem Cells
Date:7/5/2012

THURSDAY, July 5 (HealthDay News) -- As researchers suspected, abnormal bone marrow stem cells trigger the development of myelodysplastic syndromes, serious blood diseases that affect the bone marrow and can progress to leukemia, according to a new study.

"Good Morning America" host Robin Roberts recently disclosed that she had developed myelodysplastic syndrome, or MDS, as a rare complication of her breast cancer treatment. The syndrome is diagnosed in about 10,000 to 15,000 people in the United States each year, mostly in men and in those over age 60.

The new findings, published in the July 2 online edition of Blood, could lead to improved treatments for myelodysplastic syndrome and cancers related to the syndrome, researchers from the Albert Einstein College of Medicine of Yeshiva University, in New York City, suggested in an Einstein news release.

"Researchers have suspected that [myelodysplastic syndrome] is a 'stem cell disease,' and now we finally have proof," said the study's co-senior author Amit Verma, an associate professor of medicine and of developmental and molecular biology at Einstein and attending physician in oncology at Montefiore Einstein Center for Cancer Care.

"Equally important, we found that even after [myelodysplastic syndrome] standard treatment, abnormal stem cells persist in the bone marrow. So, although the patient may be in remission, those stem cells don't die and the disease will inevitably return. Based on our findings, it's clear that we need to wipe out the abnormal stem cells in order to improve cure rates," Verma explained in the news release.

For the study, the researchers analyzed bone marrow stem cells and the progenitor cells, or cells formed by stem cells, of 16 patients with various types of myelodysplastic syndrome. They compared these cells to those of 17 people who did not have the syndrome.

The investigators found widespread genetic and epigenetic (related to environmental factors) variations in the stem and progenitor cells taken from myelodysplastic syndrome patients. The abnormalities were more obvious in those with more serious forms of the disease, the researchers noted.

"Our study offers new hope that [myelodysplastic syndromes] can be more effectively treated, with therapies that specifically target genes that are deregulated in early stem and progenitor cells," the study's co-senior author Dr. Ulrich Steidl, an assistant professor of cell biology and of medicine at Einstein, said in the news release. "In addition, our findings could help to detect minimal residual disease in patients in remission, allowing for more individualized treatment strategies that permanently eradicate the disease."

More information

The U.S. National Library of Medicine has more about myelodysplastic syndromes.

-- Mary Elizabeth Dallas

SOURCE: Albert Einstein College of Medicine, news release, July 2, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Myelodysplastic syndrome treated with deferasirox shows beneficial iron reduction, Moffitt says
2. Normal triglyceride levels in people of African descent may hinder diagnosis of metabolic syndrome
3. Study: Women not getting enough exercise; at risk of developing metabolic syndrome
4. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
5. Broken heart syndrome protects the heart from adrenaline overload
6. Antibiotics Linked to Retinal Detachment Risk
7. Pesticides May Be Linked to Slightly Smaller Babies, Shorter Pregnancies
8. Pharmacy Robots Linked to Bacterial Contamination of Drugs
9. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
10. Dental X-Rays May Be Linked to Benign Brain Tumors
11. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Myelodysplastic Syndrome Linked to Abnormal Stem Cells 
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work ... as “patient engagement.” The patient is doing more than filling out a survey; in ... “There is an increasing emphasis in health care and research on the importance of ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... the certification process to promote standards of excellence for the field of eating ... for March 22 – 25, 2018 in Orlando, Florida at the Omni Resort ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the Law ... organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps our ... a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: