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Myc inhibition is an effective therapeutic strategy against most aggressive brain tumors
Date:8/18/2014

al nervous system glioblastoma, for which there is a critical call to improve current therapies which are largely ineffective. "This is the very first time that the use of Omomyc in human tumor specimens have been validated. We have also confirmed that Myc inhibition is effective against the tumor once it has developed, acts against tumor initiating cells, and prevents them from dividing, proliferating and forming the tumor again." continues Dr. Soucek.

Mitotic catastrophe as the therapeutic mechanism of Myc inhibition

The Myc protein plays an important role in regulating gene transcription, controlling the expression of up to 15% of human genes. It is also implicated in cellular proliferation, differentiation and apoptosis (programmed cell death which is necessary for tissue regeneration and the elimination of damaged cells). However, alterations in this protein trigger uncontrolled cell proliferation, which can result in cancers developing in different tissues. Myc deregulation is actually found in most tumors including cancer of the cervix, breast, colon, lung, pancreas, and stomach.

Brain tumors can now be added to this list of potential tumors that can be targeted with Myc inhibition.

At the cellular level, we now know more about its mechanism of action. Regardless of the experimental system used, Myc inhibition reduces proliferation and increases cell death. "Importantly, the cells we treated with Omomyc went crazy. They showed problems with cell proliferation, with aberrant mitosis and the formation of cells with many nuclei that then died through mitotic catastrophe, that is, due to the inability to divide properly" explains Laura Soucek. "If we do not allow Myc to function normally, tumor cells cannot divide efficiently." she affirms. Myc is not deregulated in healthy cells, hence, its inhibition does not generate any significant side effects that might limit the use of this therapy.

To conclude, Myc inhibitio
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Contact: Amanda Wren
awren@vhio.net
34-695-207-886
Vall dHebron Institute of Oncology
Source:Eurekalert  

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