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Myc inhibition is an effective therapeutic strategy against most aggressive brain tumors
Date:8/18/2014

Barcelona, 18 August 2014. Research led by the Vall d'Hebron Institute of Oncology (VHIO) evidence the most conclusive preclinical results to-date validating Myc inhibition as a therapeutic strategy in glioma a highly agressive tumor type that notoriously outsmarts current anti-cancer therapies. The study led by Laura Soucek, Principal Investigator of VHIOs Mouse Models of Cancer Therapies Group, published today in Nature Communications, not only represents an important step forward in ultimately providing brain glioma patients with new therapeutic avenues, but also reveals new insights into the biology of Myc that could further impact on its therapeutic potential.

In a study published last year, the group succeded in eradicating lung tumors in transgenic mice by adopting the same strategy involving the expression of Omomyc, a Myc inhibitor designed by Soucek. They also confirmed that there were no side effects post-administration of repeated and long-term treatment. Importantly, there was no evidence of resistance to therapy -- one of the greatest challenges in the treatment of cancer. These results therefore confirmed Myc inhibition as a sound and effective therapeutic strategy for the development of novel cancer drugs.

Soucek and her group were to raise the bar yet higher. Firstly, the focus on gene expression-based therapy under experimental study progressed and re-programed on the development of an administrable Omomyc-based drug. Second, the group continued to show the efficacy of Myc inhibition across different tumors and, above and beyond transgenic models, they showed the same success in human tumors using a technique that transfers human cancer cells to immunodeficient mice. "Upon reporting initial results at preclinical level, our main concern was how do demonstrate these findings in human tumors," says Laura Soucek. "Firstly, we focused on how they could apply to other tissues and other more aggressive tumor types for wh
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Contact: Amanda Wren
awren@vhio.net
34-695-207-886
Vall dHebron Institute of Oncology
Source:Eurekalert  

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