Navigation Links
Myc inhibition is an effective therapeutic strategy against most aggressive brain tumors
Date:8/18/2014

Barcelona, 18 August 2014. Research led by the Vall d'Hebron Institute of Oncology (VHIO) evidence the most conclusive preclinical results to-date validating Myc inhibition as a therapeutic strategy in glioma a highly agressive tumor type that notoriously outsmarts current anti-cancer therapies. The study led by Laura Soucek, Principal Investigator of VHIOs Mouse Models of Cancer Therapies Group, published today in Nature Communications, not only represents an important step forward in ultimately providing brain glioma patients with new therapeutic avenues, but also reveals new insights into the biology of Myc that could further impact on its therapeutic potential.

In a study published last year, the group succeded in eradicating lung tumors in transgenic mice by adopting the same strategy involving the expression of Omomyc, a Myc inhibitor designed by Soucek. They also confirmed that there were no side effects post-administration of repeated and long-term treatment. Importantly, there was no evidence of resistance to therapy -- one of the greatest challenges in the treatment of cancer. These results therefore confirmed Myc inhibition as a sound and effective therapeutic strategy for the development of novel cancer drugs.

Soucek and her group were to raise the bar yet higher. Firstly, the focus on gene expression-based therapy under experimental study progressed and re-programed on the development of an administrable Omomyc-based drug. Second, the group continued to show the efficacy of Myc inhibition across different tumors and, above and beyond transgenic models, they showed the same success in human tumors using a technique that transfers human cancer cells to immunodeficient mice. "Upon reporting initial results at preclinical level, our main concern was how do demonstrate these findings in human tumors," says Laura Soucek. "Firstly, we focused on how they could apply to other tissues and other more aggressive tumor types for wh
'/>"/>

Contact: Amanda Wren
awren@vhio.net
34-695-207-886
Vall dHebron Institute of Oncology
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Enzyme-inhibition could revolutionize molecular imaging
2. Inhibition of CDK4 might promote lymphoma development and progression
3. Inhibition of oral biofilm and cell-cell communication using natural-products derivatives
4. New STELARA data show inhibition of joint destruction in active psoriatic arthritis
5. Epoxide hydrolase inhibition and Thiazolidinediones: A therapy for cardiometabolic syndrome
6. Neurological Wellness Center's Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimer's, Stroke and Brain Injury is Now Being Taught in a Newly Released Video
7. Novel test identifies patients most likely to benefit from ALK inhibition therapy
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer
10. New Book on Stuttering Dispels Myths Offers New Insights for Effective Treatment
11. High-intensity exercise found safe and effective in long-term heart transplant recipients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Myc inhibition is an effective therapeutic strategy against most aggressive brain tumors
(Date:3/6/2015)... As the Muscular Dystrophy Association continues to enhance its ... two new Scientific Program Officers, Amanda Haidet-Phillips, Ph.D and ... Pavlath, Ph.D, who joined MDA late last year as ... will lead MDA as it accelerates new front-line discovery ... of neuromuscular and motor neuron diseases. , ...
(Date:3/6/2015)... Further solidifying their position as a healthcare ... that the company has earned Inavero’s Best of Staffing® ... Talent Award five years in a row. Presented in ... winners are proven industry leaders in service quality based ... they have helped find temporary and permanent jobs. With ...
(Date:3/6/2015)... 2015 First Choice Emergency Room ... facility is located at 13351 W. Bowles Avenue, Littleton, Colorado ... is ready 24-7 to provide the highest quality emergency medical ... Director of First Choice Emergency Room Littleton. , ... South Metro Denver Chamber of Commerce and a medical community ...
(Date:3/6/2015)... Houston, TX (PRWEB) March 06, 2015 ... patients safely and rapidly reach their ideal weight has ... loss products to their already impressive collection of ... new and existing clients special promotions and savings to ... embarrassing fat immediately. This promotion is especially appealing ...
(Date:3/6/2015)... FCPX developers have announced a new animated ... Hue is a lower 3rd pack with a clean and ... “Blurring the line between professional and armature, Pro3rd Hue is ... of 30 customizable lower third presets made exclusively for use ... can complement any design with a clean and simplistic style. ...
Breaking Medicine News(10 mins):Health News:MDA Adds Muscle Disease and ALS Leaders to Research Team 2Health News:MDA Adds Muscle Disease and ALS Leaders to Research Team 3Health News:MDA Adds Muscle Disease and ALS Leaders to Research Team 4Health News:Cross Country Healthcare: Medical Doctor Associates Earns Inavero's 2015 Best of Staffing Talent Diamond Award 2Health News:Cross Country Healthcare: Medical Doctor Associates Earns Inavero's 2015 Best of Staffing Talent Diamond Award 3Health News:First Choice Emergency Room Opens New Facility in Littleton, Colorado 2Health News:Diet Doc Announces Never Before Offered Discounts, Promotions and Savings for New and Existing Clients 2Health News:Diet Doc Announces Never Before Offered Discounts, Promotions and Savings for New and Existing Clients 3Health News:Diet Doc Announces Never Before Offered Discounts, Promotions and Savings for New and Existing Clients 4Health News:A New Plugin Entitled Pro3rd Hue was Released Today from Pixel Film Studios Exclusively for FCPX 2
... and other acute respiratory infections in Afghanistan // following a ... agency is sending antibiotics for thousands of people and putting ... the illnesses. ,“Early recognition and prompt treatment ... Adrian Edwards told a press briefing in Kabul, the capital. ...
... doses of steroids can inhibit joint damage when used in ... review of evidence.// ,High-quality evidence supports combining ... after diagnosis. “Such treatment should be made readily available to ... Women’s Hospital in England. ,Concern exists about ...
... Men treated for breast cancer face a significantly high ... recent study.// ,More than 10 percent of ... of the breast, stomach and skin. Hence the researchers ... any possible second onset of cancer in them. ...
... study suggests that TEMPE, a topical anesthetic spray has ... men with premature ejaculation and might be useful// as ... published in the February issue of the urology journal ... Netherlands studied 54 men with premature ejaculation, randomly assigning ...
... The Madhya Pradesh government has decided to implement a ... mothers// through several 'anganwadis' (mother and child care centres). ... 3-6 years are in full swing in the 59,324 ... said an official of the women and child welfare ...
... January to 21 January 2007, the Ministry of Health ... rate, 6.6%) in Arua/ Maracha-Terego, Koboko, and Yumbe districts, ... of the Congo. ,The population in ... living in rural, densely populated settlements. Three cerebrospinal fluid ...
Cached Medicine News:Health News:UN Sends Medicine to Afghanistan 2Health News:Low-Dose Steroids Reduce Joint Damage From Rheumatoid Arthritis 2Health News:Low-Dose Steroids Reduce Joint Damage From Rheumatoid Arthritis 3Health News:Breast Cancer in Men Lead to Second Primary Cancers 2Health News:TEMPE Spray Delays Ejaculation 2
(Date:3/5/2015)... SAN DIEGO , March 5, 2015 /PRNewswire/ ... company engaged in the development of biosimilar therapeutics ... announced today that its fourth quarter and full ... Monday, March 16, 2015, before the market opens ... management will host a conference call to discuss ...
(Date:3/5/2015)... 2015 Vermillion, Inc. (Nasdaq: ... gynecologic disease, announced today it will report fourth ... open on Wednesday, March 25, 2015, followed by ... Eastern. Conference Call & Webcast: ... Domestic: , 800-753-9057International: , 913-981-5571Conference ID: , ...
(Date:3/5/2015)... und TÜBINGEN, Deutschland, 5. März ... Gates Stiftung und das deutsche biopharmazeutische Unternehmen ... 46 Millionen Euro (52 Millionen US-Dollar) in ... Bereich der medizinisch angewandten Messenger-RNA (mRNA). Auf ... Ansätze zur Behandlung von Krankheiten und zum ...
Breaking Medicine Technology:Pfenex To Report Fourth Quarter and Full Year 2014 Results and Provide Business Update 2Vermillion to Report Fourth Quarter and Year-End 2014 Financial Results and Host an Investor Conference Call on March 25 2Bill & Melinda Gates Stiftung investiert in CureVac zur Entwicklung innovativer Impfstoffe 2Bill & Melinda Gates Stiftung investiert in CureVac zur Entwicklung innovativer Impfstoffe 3Bill & Melinda Gates Stiftung investiert in CureVac zur Entwicklung innovativer Impfstoffe 4
... N.Y., March 29, 2012 Nano Mask Inc., ... health and wellness related markets, today announced that ... agreement with Tamayz Medical, Inc. (the distributor), a ... Saudi Arabia . Tamayz has agreed to purchase ...
... (Nasdaq: ENDP ) announced today that American Medical Systems, ... the Endo devices operating company in July 2012. While the company ... initiated. Mr. Bihl joined Endo as Group President in ... and Chief Executive Officer of AMS in April 2008. ...
Cached Medicine Technology:Nano Mask Enters Into Five Year $13,000,000 Middle East Distribution Agreement with Tamayz Medical 2Endo Announces Departure of American Medical Systems President 2
We offer small and large pre-gelled Surface Electrodes suitable for EGG or EMG recordings. Surface Electrodes, Skin Preparation and Conductive Cream complete the setup for a EGG study and are essenti...
We offer small and large pre-gelled Surface Electrodes suitable for EGG or EMG recordings. Surface Electrodes, Skin Preparation and Conductive Cream complete the setup for a EGG study and are essenti...
Sandhill Scientific offers a comprehensive selection of solid state and water perfused catheters for both adult & pediatric applications.Contact Sandhill Scientific for full details...
Sandhill Scientific offers a comprehensive selection of solid state and water perfused catheters for both adult & pediatric applications.Contact Sandhill Scientific for full details...
Medicine Products: