Navigation Links
Mutations of immune system found in breast cancers
Date:11/18/2013

Mutations in the genes that defend the body against cancer-related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study at the University of Illinois at Chicago.

Bernard Friedenson, associate professor of biochemistry and molecular genetics at UIC, looked at the DNA sequences of breast cancers from 21 different women and found mutations in genes involved in immunity in every one of them. The mutations were different in each of the breast cancers he analyzed, but all the mutations would have affected some aspect of pathogen recognition and defense, especially against viruses, Friedenson said.

His results are published in the November issue of Functional & Integrative Genomics.

The finding suggests that mutations affecting the immune system play an important role in the development of breast cancer, contrary to the prevailing notion that mutations in the genes that regulate cell division are primarily responsible. Viruses such as human papilloma virus, which can cause cervical cancer, and Epstein-Barr virus, which can cause certain lymphomas, have also been implicated in breast cancer.

"Almost every human being is infected with one or more of these viruses, but most people never develop symptoms, much less breast cancer," Friedenson said.

Friedenson thinks that cancer-related viruses that are normally harmless can become dangerous if genes involved in immunity are mutated, either through heredity or environmental causes.

He identified gene mutations in breast cancer cells that affect their ability to recognize viruses, including some mutations that would be expected to significantly increase the cells' vulnerability to viruses implicated in breast cancer.

"If we know which genes are damaged in a breast cancer patient's immune system, prevention or even therapy can be tailored by giving vaccines or perhaps antiviral drugs to reduce the chances of recurrence," said Friedenson. "Sequencing the genomes of individual breast cancers now costs about $2,000, and the cost continues to fall. This information could help physicians prescribe more targeted and effective treatments."


'/>"/>

Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. First genetic mutations linked to atopic dermatitis identified in African-American children
2. Researchers at Pace University Explore the Lived Experiences of Families Members That Have the Possible Risk of Genetic Mutations That Cause Sudden Cardiac Death
3. Rapid method to detect BRAF mutations in cancer tissue samples
4. Mutations in cancer often affect the X chromosome
5. Whole DNA sequencing reveals mutations, new gene for blinding disease
6. 2 mutations triggered an evolutionary leap 500 million years ago
7. Rare genomic mutations found in 10 families with early-onset, familial Alzheimers disease
8. Mutations in susceptibility genes common in younger African American women with breast cancer
9. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
10. Tumors with ALK rearrangements can harbor more mutations
11. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... California (PRWEB) , ... June ... ... pioneer in the patient payment industry today announced its strategic partnership with ... health system workflows. , The two companies’ proven, proprietary technology combine to ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star ... , Millions of individuals in the United States and Canada wear eyeglasses. Once considered ... both correct vision and make a fashion statement. Even celebrities use glasses as a ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever Recovery, ... Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility ... home to some of the world’s leading providers of cereal and other breakfast foods. ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 The vast ... an outpatient dialysis facility.  Treatments are usually 3 times ... hours per visit, including travel time, equipment preparation and ... patient, but especially grueling for patients who are elderly ... a skilled nursing and rehabilitation centers for some duration ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
(Date:6/23/2016)... June 23, 2016  The National Pharmaceutical Council ... the health policy research organization as its newest ... MD, senior vice president and chief scientific officer, ... on the NPC Board of Directors. ... Mallinckrodt has joined us in support of our ...
Breaking Medicine Technology: