Navigation Links
Mutations in cancer often affect the X chromosome
Date:10/19/2013

Every case of cancer originates from changes in a person's genetic material (mutations). These usually occur as "somatic mutations" in individual cells during an individual's lifetime, rather than being inherited from a person's parents. "Over time, the original damaged cell accumulates additional mutations, and it is still largely unknown why," says Prof. Roland Eils, who leads bioinformatics departments both at DKFZ and Heidelberg University.

By studying when and where mutations occur the researchers hope to gain insights into the early mechanisms that send cells along a pathway to cancer. The new international study coordinated by Roland Eils has now for the first time analyzed the exact distribution of somatic mutations in the genomes of tumor cells of various types of cancer. Mutations do not affect all regions of the genome to the same extent. It is known, for example, that the number of somatic mutations depends on the sequence of bases making up a gene and the frequency at which it is transcribed into RNA molecules.

In the current study, the researchers analyzed the genome sequences of more than 400 tumors from patients suffering from twelve different types of cancer, including brain cancer in children and adults, leukemias and breast cancer.

The scientists were surprised to find that mutations were extremely frequent in the X chromosome of females, which is responsible for determining sex. In many cancers, this chromosome displayed from two to four times as many mutations as were observed in the other chromosomes. Every cell in a female has two copies of the X chromosome and interestingly the rate was not the same in the two copies. From embryonic development onwards, one of the copies is inactivated in each cell. The higher mutation rate exclusively affects the inactive copy.

This phenomenon was not found in male cancer patients, whose cells carry only one X chromosome, or in inactive X chromosomes of healthy fem
'/>"/>

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Whole DNA sequencing reveals mutations, new gene for blinding disease
2. 2 mutations triggered an evolutionary leap 500 million years ago
3. Rare genomic mutations found in 10 families with early-onset, familial Alzheimers disease
4. Mutations in susceptibility genes common in younger African American women with breast cancer
5. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
6. Tumors with ALK rearrangements can harbor more mutations
7. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
8. Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do
9. Pathologists identify patterns of mutations to help inform design of future trials
10. Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
11. University of Minnesota researchers discover enzyme behind breast cancer mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... Increases in household, construction and ... treatment volumes. However, government regulations and higher landfill ... According to IBISWorld industry analyst Alen Allday, “over ... at reducing the volume of waste generated, and ... Still, a large proportion of waste generated by ...
(Date:9/20/2014)... York (PRWEB) September 20, 2014 ... to grow in federal court, Bernstein Liebhard LLP ... Drug Administration (FDA) have voted overwhelmingly to recommend ... in men be subjected to further study in ... a report published on September 18th by Bloomberg.com, ...
(Date:9/20/2014)... Sept. 20, 2014 (HealthDay News) -- As flu season ... infection is to get a flu shot and a ... A primary care doctor can vaccinate people against the ... patients may have. Retail stores may provide flu shots ... advice, said Dr. Jorge Parada, medical director of infection ...
(Date:9/20/2014)... New York (PRWEB) September 20, 2014 ... morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological surgeries ... yet another insurer has announced plans to end ... posted on its website last month, Harrisburg, Pennsylvania-based ... effective November 1, 2014. The insurer said its ...
(Date:9/20/2014)... Traditionally dentists have advised their patients against drinking coffee and ... re-visiting that advice and changing his stance after considering two ... on oral health. “There’s good news and great news,” says ... in protecting against gum disease, and red wine can help ... from the September 2014 issue of Boston University School ...
Breaking Medicine News(10 mins):Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Waste Treatment and Disposal Services in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 2Health News:As Testosterone Lawsuits Grow, Bernstein Liebhard LLP Notes Overwhelming Vote Calling for Further Study of Testosterone Heart Risks 3Health News:Get a Flu Shot During Checkup, Doctor Says 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3
... Breakthroughs in the Field , , ... and the American Friends of The Hebrew University ... co-chair of the Bill & Melinda Gates Foundation, with its inaugural ... New York Hilton. , , ...
... MEXICO CITY and PRINCETON, N.J., Dec. 5 MetLife ... life insurance company in Mexico, and a leading provider ... today that it has partnered with Assist America, Inc., ... through employee benefit plans, to protect 500,000 of its ...
... soon be possible, thanks to a discovery made by ... Coastal Health Research Institute neuroscience researchers. , The researchers ... previously found to that cause cell death following a ... following head trauma or a stroke. , The findings, ...
... A Better Tomorrow, a fast growing,Southern California-based rehabilitation center, is ... and the United,States. , ... for their,addictions," said Sylvia Reynolds, a bilingual therapist from A ... "And these calls are ...
... and Families Embrace Life to the Fullest , ... a world-leading developer and marketer of innovative medical technologies for ... the new global lifestyle magazine for people with an ostomy. ... articles on living a healthy and active life after ostomy ...
... Anthem Blue Cross and Blue Shield,in New Hampshire has ... the current issue of U.S. News & World Report/NCQA America,s ... best health plans,is the result of outstanding overall performance in ... Anthem Blue Cross and Blue Shield ...
Cached Medicine News:Health News:Event Honoring Bill Gates Raises Over $1.5 Million for Sustainable Agriculture Research at The Hebrew University of Jerusalem 2Health News:Event Honoring Bill Gates Raises Over $1.5 Million for Sustainable Agriculture Research at The Hebrew University of Jerusalem 3Health News:MetLife Mexico Life Insurance Company Partners with Assist America for Global Emergency Medical Assistance Services 2Health News:New target discovered to treat epileptic seizures following brain trauma or stroke 2Health News:Southern California Rehabilitation Clinic is Hiring Bilingual Therapists to Better Serve the Hispanic Communities of Mexico and the United States 2Health News:ConvaTec Launches New Lifestyle Magazine for People With an Ostomy 2Health News:Anthem Blue Cross and Blue Shield in New Hampshire Ranks Among Top Insurers on U.S. News & World Report / National Committee for Quality Assurance Best Health Plans List 2Health News:Anthem Blue Cross and Blue Shield in New Hampshire Ranks Among Top Insurers on U.S. News & World Report / National Committee for Quality Assurance Best Health Plans List 3
(Date:9/19/2014)... The American Association for Homecare (AAHomecare) is ... has joined the AAHomecare Corporate Partner Program. ... have been actively involved in AAHomecare for much of ... grown into a major global manufacturer of home medical ... to increase efforts on behalf of the HME sector ...
(Date:9/19/2014)... 2014 Larry J. Merlo , President and ... speak before the National Press Club in Washington, ... move to stop selling tobacco products and its leadership in ... "Dramatic changes in our health care system pose ... Merlo has said. "CVS Health has a truly unique combination ...
(Date:9/19/2014)...  Lpath, Inc. (NASDAQ: LPTN ), ... today that it has entered into definitive agreements ... and 3,605,042 unregistered warrants in a registered direct ... share of common stock and one unregistered warrant ... will be $3.475.  The warrants have an exercise ...
Breaking Medicine Technology:Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3Lpath, Inc. Announces $12.5 Million Registered Direct Offering 2Lpath, Inc. Announces $12.5 Million Registered Direct Offering 3
... , BEDFORD, Ohio , Jan. 14 ... is pleased to announce FDA approval for the addition of ... line. This product is AP rated and is equivalent to ... for oropharyngeal and esophageal candidiasis, cryptococcal meningitis, and is indicated ...
... , , BETHLEHEM, Pa. , Jan. 13 ... and easy-to-use WHIN ® Safe Huber Needle , an implantable ... a single Huber Needle and provides clinicians with advanced protection ... http://www.newscom.com/cgi-bin/prnh/20081022/NYW008LOGO ) , There are three models of the WHIN ® ...
Cached Medicine Technology:Bedford Laboratories(TM) To Begin Shipping Fluconazole Injection 2Bedford Laboratories(TM) To Begin Shipping Fluconazole Injection 3Bedford Laboratories(TM) To Begin Shipping Fluconazole Injection 4B. Braun Introduces WHIN(R) Safe Huber Needle 2B. Braun Introduces WHIN(R) Safe Huber Needle 3B. Braun Introduces WHIN(R) Safe Huber Needle 4
... broad selection of tip styles for ... ophthalmic procedures. Each single use cautery ... safety cap to lock switch in ... in use, and carries a 3-4 ...
... a broad selection of tip styles ... of ophthalmic procedures. Each single use ... a safety cap to lock switch ... not in use, and carries a ...
... Accu-Temp Cauteries provide a broad selection ... a wide variety of ophthalmic procedures. ... sterile, complete with a safety cap ... " position when not in use, ...
... The B-VAT® PC visual acuity system ... features of the B-VAT II. The system ... sequencing, contrast sensitivity testing and animated characters. ... the operator has single letter, single line ...
Medicine Products: