Navigation Links
Mutations in cancer often affect the X chromosome
Date:10/19/2013

Every case of cancer originates from changes in a person's genetic material (mutations). These usually occur as "somatic mutations" in individual cells during an individual's lifetime, rather than being inherited from a person's parents. "Over time, the original damaged cell accumulates additional mutations, and it is still largely unknown why," says Prof. Roland Eils, who leads bioinformatics departments both at DKFZ and Heidelberg University.

By studying when and where mutations occur the researchers hope to gain insights into the early mechanisms that send cells along a pathway to cancer. The new international study coordinated by Roland Eils has now for the first time analyzed the exact distribution of somatic mutations in the genomes of tumor cells of various types of cancer. Mutations do not affect all regions of the genome to the same extent. It is known, for example, that the number of somatic mutations depends on the sequence of bases making up a gene and the frequency at which it is transcribed into RNA molecules.

In the current study, the researchers analyzed the genome sequences of more than 400 tumors from patients suffering from twelve different types of cancer, including brain cancer in children and adults, leukemias and breast cancer.

The scientists were surprised to find that mutations were extremely frequent in the X chromosome of females, which is responsible for determining sex. In many cancers, this chromosome displayed from two to four times as many mutations as were observed in the other chromosomes. Every cell in a female has two copies of the X chromosome and interestingly the rate was not the same in the two copies. From embryonic development onwards, one of the copies is inactivated in each cell. The higher mutation rate exclusively affects the inactive copy.

This phenomenon was not found in male cancer patients, whose cells carry only one X chromosome, or in inactive X chromosomes of healthy fem
'/>"/>

Contact: Dr. Sibylle Kohlstädt
s.kohlstaedt@dkfz.de
German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Whole DNA sequencing reveals mutations, new gene for blinding disease
2. 2 mutations triggered an evolutionary leap 500 million years ago
3. Rare genomic mutations found in 10 families with early-onset, familial Alzheimers disease
4. Mutations in susceptibility genes common in younger African American women with breast cancer
5. Mount Sinai Researchers Identify Gene Mutations in Congenital Heart Disease
6. Tumors with ALK rearrangements can harbor more mutations
7. Some patients with incurable tumors and BRCA mutations respond to new 2-drug combination
8. Blood tests can provide fuller picture of mutations in cancer than traditional biopsies do
9. Pathologists identify patterns of mutations to help inform design of future trials
10. Gene Mutations Appear Key to Childhood Leukemia Risk, Study Says
11. University of Minnesota researchers discover enzyme behind breast cancer mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Allegheny General Hospital’s (AGH) Cardiovascular Institute ... to repair a damaged mitral valve as the heart ... developed by Abbott Vascular , is designed to ... condition in which the heart’s mitral valve leaflets fail ... the heart’s left ventricle into the left atrium. The ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 T.E.N., ... relationship-marketing firm, announced today that William H. Murray, ... the 2014 ISE® Luminary Leadership Award winner. Presented ... achievements of an outstanding leader and industry practitioner ... contributions in advancing the information security industry. , ...
(Date:10/20/2014)... WA (PRWEB) October 20, 2014 My ... workflow management software application. The new module enables ... patients receive full life-cycle quality care. , This application ... others within their practice, attach a to-do item to ... fit, and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... Rockynol Retirement Community broke ground on ... $11 million project will include the latest in Assisted ... full-service restaurant style dining. , “We are excited to ... Living apartments,” said Kara Hanzie, Rockynol Executive Director during ... care and this investment is proof of our commitment.” ...
(Date:10/20/2014)... Final Cut Pro X Plugin developers from ... theme for FCPX filmmakers . , “Fun, cool, and ... Citrus theme” Says Christina Austin, CEO of Pixel Film Studios. ... , Citrus comes with all the tools needed for a ... transitions for added style, a title screen for an introduction, ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 2Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 3Health News:Bill Murray named 2014 ISE® Luminary Leadership Award Winner 4Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Rockynol Retirement Community Expands Assisted Living Center 2Health News:Today Pixel Film Studios Announced the Release of the Citrus theme for Final Cut Pro X 2
... Smith III, O.D., dean of the College of Optometry at ... his work in slowing the progression of nearsightedness in children. ... chair, accepted the Donald Korb Award for Excellence at a ... of the American Optometric Association (AOA). The Korb ...
... Many members of low-income families are not getting proper nutrition ... the families, eating patterns and the nutritional value of their ... the 100 families, who were newly enrolled in the Nebraska ... vital nutrients, including vitamins A and C, protein, calcium and ...
... June 28, 2011A chemical produced by the same cells that ... 1 diabetes in mice, researchers at St. Michael,s Hospital have ... is characterized by the immune system,s destruction of the beta ... a result, the body makes little or no insulin. ...
... new insight into the brain processes that cause the following ... in the center of the image in this short video ... of the University of Rochester) appears to be expanding. But ... he is growing because our brains have adapted to the ...
... identified specific resistance mutations for two classes of p7 ... clinical trials combined with current standard of care. Study ... potential components of future HCV-specific therapies and are available ... journal published by Wiley-Blackwell on behalf of the American ...
... (HealthDay News) -- A flexible work schedule helps employers retain ... birth, according to a new study. "When confronted by ... moms with alternatives for meeting those demands while caring for ... their work environment and adapt, work-related stress is less likely ...
Cached Medicine News:Health News:Work to slow progression of nearsightedness in children wins award 2Health News:Low-Income Families Often Miss Out on Proper Nutrition 2Health News:Chemical produced in pancreas prevented and reversed diabetes in mice 2Health News:Neuroscientists find famous optical illusion surprisingly potent 2Health News:P7 protein resistance mutations identified; represent drug targets for hepatitis C virus 2Health News:Flexible Schedule Helps Keep New Moms in the Workplace 2
(Date:10/17/2014)... , Oct. 17, 2014 A victim of medical ... doctor with a history of alcohol abuse, a ... Yes on Prop 46 today, highlighting how Prop 46 will ... alcohol testing. The ad pictures a doctor ... "911-Report To ER."  Proposition 46 will enact the first law ...
(Date:10/17/2014)... , Oct. 17, 2014 The ... Medical Technology Policy: The Green Park ... FDA, public and private payers, medical device and ... and other experts January 12, 2015 at its ... value of weight loss treatments.  Participants will discuss ...
(Date:10/17/2014)... 2014  UBM Medica US announces that Endocrinology ... other clinicians who treat patients with type 2 ... use of insulin .  Nearly all ... therapy – daily injections of one or more ... the function of pancreatic beta cells. Insulin is a ...
Breaking Medicine Technology:Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3
... NATICK, Mass., March 29, 2011 Boston Scientific Corporation ... trial news and events schedule at the 60th Annual ... April 2-5, 2011 in New Orleans. "Twelve-month ... important data on our next-generation PROMUS Element™ Everolimus-Eluting Platinum ...
... 2011 Tris Pharma, Inc., a specialty pharmaceutical company, ... Iron product line.  Since the 2007 launch ... of pediatricians, pediatric nurses and mothers.  When the previous ... different direction, availability of MyKidz Iron™ became limited, but ...
Cached Medicine Technology:Boston Scientific Announces Its ACC 2011 Schedule 2Boston Scientific Announces Its ACC 2011 Schedule 3Boston Scientific Announces Its ACC 2011 Schedule 4Boston Scientific Announces Its ACC 2011 Schedule 5Boston Scientific Announces Its ACC 2011 Schedule 6Tris Pharma Announces Availability of the MyKidz® Iron Product Line - the Best Tasting Iron Supplements 2Tris Pharma Announces Availability of the MyKidz® Iron Product Line - the Best Tasting Iron Supplements 3
It is available in a 5cc-balloon version with round tip and two opposing eyes, and a 30cc-balloon version with two staggered eyes. BARDEX Silicone-Elastomer Foley Catheters are also available in kits...
All-silicone construction provides maximum softness and biocompatibility for enhanced patient comfort. Supplied sterile in peel-open packages. Intended for one-time use....
The BARDEX I.C. Catheter represents Bard's newest technology in providing protection against NUTI....
Used to provide bladder drainage by percutaneous placement of a Malecot catheter. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: