Navigation Links
Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
Date:6/15/2012

PHILADELPHIA A substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 gene mutations. Patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

"Very little was known about the genetic and molecular defects causing NK/T-cell lymphoma before we started this work," said Bin Tean Teh, M.D., Ph.D., director of the National Cancer Center Singapore-Van Andel Research Institute Translational Research Laboratory at the NCCS, and professor at the Duke-NUS Graduate Medical School in Singapore. "There is no effective treatment and this type of cancer carries an extremely poor prognosis.

"It is tremendously rewarding to have identified genetic mutations that appear to have an important role in driving the cancer in a considerable fraction of cases. Moreover, we are excited that there is a drug already in phase III trials for the treatment of rheumatoid arthritis that targets the mutant protein. We are in the process of planning a clinical trial to study whether this drug benefits NK/T-cell lymphoma patients," said Teh.

NK/T-cell lymphoma is a very aggressive form of lymphoma. It is particularly prevalent in Asia.

"Many years ago, I and a colleague came to the Van Andel Research Institute in Grand Rapids, Mich.," said Teh. "My colleague unfortunately developed NK/T-cell lymphoma and passed away. It was the only case of this cancer ever diagnosed in Grand Rapids. As this illustrates, it is a relatively rare subtype of lymphoma in the United States, but it is responsible for the deaths of a large number of people in Asia, in particular in China and Korea. It accounts for almost half of all T-cell lymphomas in some parts of Asia.

"The passing of my colleague, whom I was very close to, was the reason that I started studying NK/T-cell lymphoma. It has been a complicated puz
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers Find Gene Mutations That May Be a Key to Autism
2. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
3. Cancer may require simpler genetic mutations than previously thought
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Study sheds new light on role of genetic mutations in colon cancer development
6. Predictors identified for rehospitalization among post-acute stroke patients
7. 2 repressor genes identified as essential for placental development
8. Possible new cancer treatment identified
9. Gene Behind Psoriasis Identified, Researchers Say
10. A microRNA prognostic marker identified in acute leukemia
11. Early biomarker for pancreatic cancer identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... For some people, tattoos are works of art that ... their lives, as they have spent a great deal of ... amount of thought on their designs. For others, however, tattoos ... simply want them removed for personal or professional reasons. In ... 2012-13 there was a 43 percent increase in the number ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 Carinsurancehints.com has released ... insurance plans that offer financial protection against fire damage. ... will pay benefits in case their vehicle is set intentionally ... vandalism caused by rioting or by other things. , ... quotes on a single website http://www.carinsurancehints.com/ , in ...
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog ... auto insurance prices . , Drivers who ... theft may have to pay more for auto insurance ... policies can also offer protection against vehicle theft. ... online on a single website: http://lowcostcarinsuranceprice.com/ . ...
(Date:4/18/2015)... More than 2000 styles of newly ... the #1 online store carrying celebrity inspired special occasion ... got their perfect dresses for their prom. For those ... dresses at TheCelebrityDresses.com would be an ideal choice. ... prom dresses inspired by the most loved styles seen ...
(Date:4/18/2015)... Montreal, Canada (PRWEB) April 18, 2015 ... of emotions on food choices when he uttered, “Tell ... what you are.” Using food to cope with stress ... research by Queendom.com indicates otherwise. Data collected ... both genders fall victim to emotional eating, but for ...
Breaking Medicine News(10 mins):Health News:Dennis Dass, M.D. is Shattering the Past While Revealing the Future 2Health News:Online Auto Insurance Quotes For Plans That Cover Fire Damages! 2Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6
... , OAKLAND, Calif., Aug. 5 Anyone ... record in a standardized format understood at hospitals, clinics and ... specializing in chronic illness support, geriatric care management and private ... Your Own Health to re-brand and sell the popular ...
... , , PHOENIX, Aug. 5 ... hand must not become a vehicle for taking lives through abortion ... report at the organization,s 127th annual convention here today. Referring to ... declared that "Health care reform must be abortion-free." , , ...
... direction for diabetes treatment , WEDNESDAY, Aug. 5 (HealthDay News) ... role in the control of blood sugar production in the ... first time that CCK from the gut activates receptors to ... axis," Tony Lam of the University of Toronto said in ...
... , , , ... a privately-held specialty pharmaceutical company, today announced that it has ... IMS data indicates the combined U.S. market for these two ... and shipping both products immediately. , , ...
... an animal model that provides strong evidence why imatinib, marketed ... but does not keep the disease from returning if treatment ... drug,s radar and enable the disease to recur in most ... issue of Cancer Cell . The researchers ...
... An internationally recognized Virginia Commonwealth University physician has ... Award for his pioneering contributions that have advanced the ... past recipients who have made a remarkable impact on ... Foundation for Infectious Diseases awarded the honor to Richard ...
Cached Medicine News:Health News:Portable Health Care Records Now Available for Consumers 2Health News:'Health Care Reform Must be Abortion-Free,' says Supreme Knight 2Health News:Sagent Pharmaceuticals Announces Launch of First Two Oncolytic Products: Fludarabine Phosphate for Injection, USP and Epirubicin Hydrochloride Injection 2Health News:Finding key to cancer drug Gleevec's limitations 2Health News:National Foundation for Infectious Diseases honors VCU physician with Maxwell Finland Award for 2010 2Health News:National Foundation for Infectious Diseases honors VCU physician with Maxwell Finland Award for 2010 3
(Date:4/17/2015)... , April 17, 2015 ... Market Research Report on Global and China Lysine ... is a professional and the deep research report ... introduces Lysine basic information including definition, classification specifications, ... as US, Europe , ...
(Date:4/17/2015)... WOONSOCKET, R.I , April 17, 2015 ... holding a conference call on Friday, May 1, 2015, ... discuss its first quarter financial results. An ... simultaneously through the Investor Relations portion of the CVS ... webcast, visit http://investors.cvshealth.com . This webcast will be ...
(Date:4/17/2015)... April 17, 2015  Trovagene, Inc., (NASDAQ:  TROV) ... that clinical data presented at the 2015 European ... Precision Cancer Monitoring ℠ (PCM) platform outperformed ... EGFR T790M mutations in metastatic lung ... EGFR T790M Mutation in Urinary Circulating Tumor DNA ...
Breaking Medicine Technology:Lysine Market International (US, Europe, Japan) Research Analysis 2Lysine Market International (US, Europe, Japan) Research Analysis 3Lysine Market International (US, Europe, Japan) Research Analysis 4Lysine Market International (US, Europe, Japan) Research Analysis 5Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4
... 5 system is an intuitive, all-in-one ... to minimize the scarring and risk ... procedures. Incorporating an enhanced, ergonomic handle ... operative obstructions, this new device is ...
... The Arrow LionHeart Left Ventricular Assist System ... designed to be used as a destination ... (Class IV) congestive heart failure, for which ... Arrow LionHeart LVAS is not intended as ...
... The TandemHeart PTVA ( Percutaneous ... proprietary solution for the hemodynamic needs of ... and Cardiac Surgeons. These specialists have ... some coronary artery perfusion, but the IABP ...
The MicroMed DeBakey VAD is a miniaturized heart pump designed to provide increased blood flow (up to 10L/min) from the left ventricle of the heart throughout the body for patients in end stage heart...
Medicine Products: