Navigation Links
Mutations in JAK3 gene identified in subtype of lymphoma provide potential drug target
Date:6/15/2012

PHILADELPHIA A substantial proportion of NK/T-cell lymphomas harbor Janus Kinase 3 gene mutations. Patients with these lymphomas might benefit from treatment with a Janus Kinase inhibitor according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

"Very little was known about the genetic and molecular defects causing NK/T-cell lymphoma before we started this work," said Bin Tean Teh, M.D., Ph.D., director of the National Cancer Center Singapore-Van Andel Research Institute Translational Research Laboratory at the NCCS, and professor at the Duke-NUS Graduate Medical School in Singapore. "There is no effective treatment and this type of cancer carries an extremely poor prognosis.

"It is tremendously rewarding to have identified genetic mutations that appear to have an important role in driving the cancer in a considerable fraction of cases. Moreover, we are excited that there is a drug already in phase III trials for the treatment of rheumatoid arthritis that targets the mutant protein. We are in the process of planning a clinical trial to study whether this drug benefits NK/T-cell lymphoma patients," said Teh.

NK/T-cell lymphoma is a very aggressive form of lymphoma. It is particularly prevalent in Asia.

"Many years ago, I and a colleague came to the Van Andel Research Institute in Grand Rapids, Mich.," said Teh. "My colleague unfortunately developed NK/T-cell lymphoma and passed away. It was the only case of this cancer ever diagnosed in Grand Rapids. As this illustrates, it is a relatively rare subtype of lymphoma in the United States, but it is responsible for the deaths of a large number of people in Asia, in particular in China and Korea. It accounts for almost half of all T-cell lymphomas in some parts of Asia.

"The passing of my colleague, whom I was very close to, was the reason that I started studying NK/T-cell lymphoma. It has been a complicated puz
'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers Find Gene Mutations That May Be a Key to Autism
2. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
3. Cancer may require simpler genetic mutations than previously thought
4. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
5. Study sheds new light on role of genetic mutations in colon cancer development
6. Predictors identified for rehospitalization among post-acute stroke patients
7. 2 repressor genes identified as essential for placental development
8. Possible new cancer treatment identified
9. Gene Behind Psoriasis Identified, Researchers Say
10. A microRNA prognostic marker identified in acute leukemia
11. Early biomarker for pancreatic cancer identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... September 04, 2015 , ... Inmar announced today that its ... its Product, Quality and Manufacturers, Dietary Supplements and Supply Chain Committees. , With ... consumer goods industry, it can be difficult for companies to navigate, stay abreast ...
(Date:9/4/2015)... ... , ... “Getting away from the daily stressors and distractions of life may ... ‘couple-ness,’” says Jean Claude Wietzel, general manager at Four Seasons Resort Maui at ... Forbes Five Star resort and Travel + Leisure’s No. 1 Hotel in Hawaii, has ...
(Date:9/4/2015)... ... 04, 2015 , ... The conference program for the upcoming ... 9-10, 2015 at the Diplomat Resort & Spa has been announced and is ... at the top of their field and will be presenting sessions such as ...
(Date:9/4/2015)... Washington, DC (PRWEB) , ... September 04, 2015 ... ... dollar-wise they all pale in comparison to settlements under the Stark physician self-referral ... an upcoming Sept. 17 webinar from Atlantic Information Services, Inc. (AIS), will ...
(Date:9/3/2015)... (PRWEB) , ... September 04, 2015 , ... AlignLife ... of September. , "There are so many children and adults who don't have ... says Dr. Sara Mahalko-Leonhardt. "We love holding our annual Coat Drive to help those ...
Breaking Medicine News(10 mins):Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 3Health News:Couples Season at Four Seasons Resort Maui Begins This Week With Best Hotel Rates of the Year through November 2Health News:Couples Season at Four Seasons Resort Maui Begins This Week With Best Hotel Rates of the Year through November 3Health News:Integrative Healthcare Symposium Focus On: The Microbiome Conference Program Announced 2Health News:Sept. 17 Webinar to Offer Best Practices for Physician Contracts 2Health News:AlignLife is Helping to Keep the Community Warm This Winter 2
... Nov. 3 (HealthDay News) -- The rate of concussions among ... times higher than previously believed, and the issue needs to ... researchers warn. The study of 67 male ice-hockey players, ... during the 2009-2010 hockey season. During 52 games, 17 players ...
... TUESDAY, Nov. 2 (HealthDay News) -- One of the main ... symptoms in patients with early Alzheimer,s, although experts aren,t ruling ... the disease. The supplement, docosahexaenoic acid (DHA), is present ... it might play a role in treatment. But that ...
... report decreased pain and improved breathing following treatment of ... the therapy falls short of improving survival. Still, ... Cancer Center and presented today at the annual meeting ... BC, represents the first of its kind to document ...
... Birthdays Are Harder to Remember Than Others ( http://pss.sagepub.com/content/21/10/1525.abstract ... People may have a better memory for birthdays that ... birthdays tended to remember birthdays that were closer to ... their own birthday. In a separate experiment, after reading ...
... patients with the most common form of hepatitis C being ... hepatitis Cspecific protease inhibitor called telaprevir to the current standard ... cure) rate., The lead ... Ira M. Jacobson, chief of the Division of Gastroenterology and ...
... Serena Gordon HealthDay Reporter , TUESDAY, Nov. ... aren,t getting much-needed hospice care because the admission criteria ... cause of death in the U.S., and hospice care ... getting palliative [comfort] care is guidelines that try to ...
Cached Medicine News:Health News:Concussion Rate in Young Hockey Players Higher Than Thought 2Health News:Concussion Rate in Young Hockey Players Higher Than Thought 3Health News:Fish Oil Supplements May Not Slow Alzheimer's 2Health News:Fish Oil Supplements May Not Slow Alzheimer's 3Health News:Lombardi research: Robotic radiosurgery offers palliative care for hilar lung tumors 2Health News:New research from Psychological Science 2Health News:New research from Psychological Science 3Health News:New research from Psychological Science 4Health News:Hepatitis C study shows superior viral cure rate 2Health News:Study Casts Doubt on Hospice Admission Criteria for Patients With Dementia 2Health News:Study Casts Doubt on Hospice Admission Criteria for Patients With Dementia 3
(Date:9/4/2015)... India , September 4, 2015 ... 2015 Market Research Report is a professional and ... global Surgical Gown industry with a focus on ... take 2-3 working days once an order is ... market spread across 150 pages, analyzing and profiling ...
(Date:9/4/2015)... PLAINFIELD, N.J. , Sept. 4, 2015 /PRNewswire/ ... pleased to announce five recipients of its first-ever ... Realize Innovation, Vision and Empowerment), designed to aid ... Duchenne muscular dystrophy (DMD) community. The announcement is ... the international World Duchenne Awareness Day on Monday, ...
(Date:9/4/2015)... , Sept. 4, 2015  Allergan plc (NYSE: AGN ... Brent Saunders , CEO and President of Allergan, will provide ... Morgan Stanley Global Healthcare Conference 2015 in New ... The presentation will take place on ... the Grand Hyatt New York, 109 East 42nd Street, ...
Breaking Medicine Technology:Surgical Gown Market 2020 Forecasts With a Focus on China 2Surgical Gown Market 2020 Forecasts With a Focus on China 3Surgical Gown Market 2020 Forecasts With a Focus on China 4PTC Therapeutics Announces Five Winners In Its First-ever Global Duchenne Muscular Dystrophy Patient Group Award 2PTC Therapeutics Announces Five Winners In Its First-ever Global Duchenne Muscular Dystrophy Patient Group Award 3PTC Therapeutics Announces Five Winners In Its First-ever Global Duchenne Muscular Dystrophy Patient Group Award 4Allergan to Present at Morgan Stanley Global Healthcare Conference 2015 2Allergan to Present at Morgan Stanley Global Healthcare Conference 2015 3
... March 31, 2011 Reportlinker.com announces that a ... catalogue: Molecular Diagnostics in ... http://www.reportlinker.com/p0368860/Molecular-Diagnostics-in-Infectious-Disease-Testing.html This TriMark Publications report ... diagnostics market known as molecular diagnostics testing for ...
... 2011 Reportlinker.com announces that a new ... catalogue: Gout Therapeutics Market ... as Krystexxa, Uloric, Adenuric and Colcrys to ... Gout Therapeutics Market to ...
Cached Medicine Technology:Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 2Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 3Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 4Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 5Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 6Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 7Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 8Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 9Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 10Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 11Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 12Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 13Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 14Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 15Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 16Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 17Reportlinker Adds Molecular Diagnostics in Infectious Disease Testing 18Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 2Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 3Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 4Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 5Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 6Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 7Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 8Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 9Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 10Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 11Reportlinker Adds Gout Therapeutics Market to 2017- Entry of Novel Therapies such as Krystexxa, Uloric, Adenuric and Colcrys to Drive Market 12