Navigation Links
Mutations common to cancer and developmental disorder examined in a novel disease model
Date:12/21/2008

December 22, 2008, Cambridge, UK New research sheds light on a common link between tumor formation and Costello Syndrome, an inherited developmental disorder in which patients have cardiac defects, mild mental retardation, and face-shape abnormalities. The study published in the journal Disease Models & Mechanisms (DMM), dmm.biologists.org uses a zebrafish model to help explain a puzzling connection between Costello syndrome and cancer.

Costello Syndrome is one of several developmental disorders caused by mutations in a gene known as H-RAS. Additionally, mutations in H-RAS and the Ras family of genes are common in most human cancers. Thus, scientists are trying to determine how genetic mutations that activate H-RAS can cause a congenital illness as well as cancer . In this new study, Cristina Santoriello and colleagues investigate this mystery by expressing activated H-RAS in zebrafish, which are often used to study the developmental process. They found that the effect of mutant H-RAS in part depends on the timing and level of gene expression. Higher levels of H-RAS caused overabundant cell-growth, reminiscent of tumors. Furthermore, zebrafish expressing mutant H-RAS through development displayed hallmarks of the human Costello Syndrome, such as reduced body size, heart defects, and physical deformities.

This new model of Costello Syndrome can be used to learn more about this disease, particularly in regard to symptoms that worsen with age. Additionally, using this model to examine the developmental processes that control cancerous mutant H-RAS effects can potentially lead to novel cancer therapies.


'/>"/>

Contact: Donna Perry
donna@biologists.com
44-012-234-33319
The Company of Biologists
Source:Eurekalert

Page: 1

Related medicine news :

1. Gene Mutations May Cause Rare Neonatal Diabetes
2. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
3. BRCA Mutations Dont Raise Breast Cancer Risk Equally
4. Genetic Mutations Boost Prostate Cancer Risk
5. Scientists explore factors contributing to DNA mutations
6. Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
7. 2 Mutations Were Critical to Spread of 1918 Flu
8. Einstein researchers discover gene mutations linked to longer lifespans
9. Gene Mutations for Rare Heart Disease Also Found in Kids
10. Different mutations in single gene suggest Parkinsons is primarily an inherited genetic disorder
11. Second breast cancer may be greater than thought for high-risk women without BRCA mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... ... announced that they have enrolled over 100,000 children in their treatment program. Clubfoot ... every year in areas where treatment is limited or non-existent. Without intervention, these ...
(Date:7/24/2017)... Church, VA (PRWEB) , ... July 24, 2017 ... ... figuring out how to change manufacturers future. , The agency is hammering out ... Cures Act, one of the farthest-ranging laws ever to affect FDA-regulated firms. The ...
(Date:7/24/2017)... ... July 24, 2017 , ... “The Perfect Gift”: a customizable and interactive Bible study guide ... Huckett is a born-again Christian. She has always accepted Christ as her Savior, yet ... She was in the Spirit when she wrote this book to her children, so they ...
(Date:7/24/2017)... ... ... “Journey to the Light: The Quest for Happiness and Love. . . through ... herself. “Journey to the Light: The Quest for Happiness and Love. . . ... newsletters, manuals, and articles, who has recently decided to expand her literary horizons and ...
(Date:7/23/2017)... ... July 23, 2017 , ... ... education and training standards for healthcare treatment providers, offers healthcare professionals a ... iaedp™ Core Curriculum. , Presented as either online or as a 2-day, ...
Breaking Medicine News(10 mins):
(Date:7/5/2017)... MINNEAPOLIS , July 5, 2017 Pace Analytical, a company of ... announcing today that they have acquired ESC Lab Sciences, further solidifying their position ... the United States . ... Steve Vanderboom- President and CEO of Pace Analytical ... of ESC Lab Sciences out of Mt Juliet, TN , ...
(Date:6/30/2017)... Md. , June 30, 2017 In ... since the start of May, at least ten diagnostic ... include private investments, public offerings and a loan facility.  ... million to almost $80 million.  Kalorama Information provides a ... of its Diagnostics Knowledge Center. ...
(Date:6/27/2017)... TEL AVIV, Israel , June 27, 2017 /PRNewswire/ ... a specialty clinical-stage pharmaceutical company specializing in the development ... ring The Nasdaq Stock Market Opening Bell in ... 28, 2017 in honor of its initial public offering ... Nasdaq Capital Market in March 2017. Dr. ...
Breaking Medicine Technology: