Navigation Links
Mutation database helps personalized treatment of lung cancer
Date:4/25/2008

A groundbreaking free tool to help oncologists choose the best therapies for patients with non-small-cell lung cancer has been launched this week by scientists at the 1st European Lung Cancer Conference jointly organized by the European Society for Medical Oncology (ESMO) and the International Association for the Study of Lung Cancer (IASLC) in Geneva, Switzerland.

The online database brings together data on all the known somatic mutations (tumor derived - tumor specific) in a molecule called epithelial growth factor receptor (EGFR). Somatic mutations in this cell-surface molecule are known to affect treatment with the newer tyrosine kinase inhibitor class of drugs.

"We have known for some time that some EGFR mutations correlate with response to tyrosine kinase inhibitors for lung cancer patients," says Dr. Samuel Murray from Department of Molecular Pathology and Translational Oncology, Metropolitan Hospital, Athens, Greece. "But there have been so many articles published on this topic that we felt that it would be virtually impossible for any given center or individual to interpret the clinical relevance of a given mutation."

"So we worked on the assumption that a comprehensive list of all somatic EGFR mutations coupled with data on the response of non-small-cell lung cancers treated with tyrosine kinase inhibitors (TKIs) would help clinicians determine whether a specific mutation was likely to correlate with clinical benefit."

The database includes cumulative data from thousands of patients. In addition, independent patient data (IPD) for patients who have been treated with tyrosine kinase inhibitors and some who have not, is being added. A total of 12,244 patients are included, of whom 3,381 had somatic mutations in EGFR. The researchers catalogued 254 different mutations.

Ultimately, the database offers a chance to improve treatment for people receiving tyrosine kinase inhibitors. "We believe that for the more common mutations the database allows clinicians to make more robust decisions concerning their treatment options for NSCLC," says Dr. Murray.


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
41-919-731-907
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. Mutation in human gene helps protect against fatal malaria
2. Breast cancer risk amplified by additional genes in combo with BRCA mutation
3. Different mutations in single gene suggest Parkinsons is primarily an inherited genetic disorder
4. Gene Mutations for Rare Heart Disease Also Found in Kids
5. Researchers Find Gene Mutation That Increases Asthma Risk
6. Rare Gene Mutation Plays Role in Longevity
7. Einstein researchers discover gene mutations linked to longer lifespans
8. Genetic mutation found in peripheral artery disease
9. 2 Mutations Were Critical to Spread of 1918 Flu
10. Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
11. Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... London, ... was honored to serve earlier this month as a Guest Speaker and Contributor to ... British Royal Family and Common Purpose. , Walter Schindler and ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to months ... officials call for diligence, asking homeowners to scout for any open water sources that ... with the annoying buzz of mosquitos is the buzz associated with potential infections stemming ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech ... in the modern ART laboratory, to provide hands-on training utilizing cutting-edge equipment at ... NextGen LifeLabs, a MedTech Group Purchasing vendor , will provide specialized equipment ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients from Charleston, SC, are ... dentist practicing in Mt. Pleasant, SC, with or without a referral. A full mouth ... with missing teeth in Charleston, SC. Those who suffer from gum disease, ...
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... New ... gums and chronic bad breath, can now receive laser gum disease treatments from the ... Douglas Campbell and David Landau are raising awareness of the importance of receiving qualified ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)...  Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... focused on the development of oral drug delivery ... Office has granted Oramed a patent titled, "Methods ... patent covers Oramed,s invention of an oral glucagon-like ... incretin hormone that stimulates the secretion of insulin ...
(Date:5/6/2017)... IRVING, Texas , May 5, 2017   Provista ... 1994 with more than 200,000 customers, today announced Jim ... brings a wealth of executive and business experience to Provista, ... a compounding pharmacy in California . He ... "Jim is a great fit for Provista," says ...
(Date:5/4/2017)... , May 4, 2017  A recent study ... Ultraviolet-C light as a means of ... ability to reduce bioburden on anesthesia workstations. In ... on high-touch, complex medical equipment surfaces contaminated with ... "This study further validates the body ...
Breaking Medicine Technology: