Navigation Links
Mutation breaks HIV's resistance to drugs
Date:9/13/2012

The human immunodeficiency virus (HIV) can contain dozens of different mutations, called polymorphisms. In a recent study an international team of researchers, including MU scientists, found that one of those mutations, called 172K, made certain forms of the virus more susceptible to treatment. Soon, doctors will be able to use this knowledge to improve the drug regiment they prescribe to HIV-infected individuals.

"The 172K polymorphism makes certain forms of HIV less resistant to drugs," said Stefan Sarafianos, corresponding author of the study and researcher at MU's Bond Life Sciences Center. "172K doesn't affect the virus' normal activities. In some varieties of HIV that have developed resistance to drugs, when the 172K mutation is present, resistance to two classes of anti-HIV drugs is suppressed. We estimate up to 3 percent of HIV strains carry the 172K polymorphism."

HIV is a retrovirus, meaning it uses an enzyme called reverse transcriptase to create copies of its own genetic code. These copies are inserted into the victim's own genes where the virus highjacks the host's cellular machinery in order to reproduce itself. Two classes of drugs, nucleoside (NRTIs) and non-nucleoside reverse transcriptase inhibitors (NNRTIs), can stop this process in its tracks.

However, some HIV strains have developed resistance to NRTIs and NNRTIs. The 172K polymorphism suppresses this resistance and allows both classes of drugs to fight HIV more efficiently. The mutation is believed to be the first of its kind that blocks resistance to two families of drugs.

"Clinical doctors use a database of HIV mutations and the drugs they are susceptible to when they prescribe treatments to an HIV-infected patient," Sarafianos said. "Our finding will be integrated into this database. Once that happens, when doctors learn that their patients have HIV strains that carry the 172K polymorphism, they will know that the infections can be fought better with NRTIs and NNRTIs."

One of Sarafianos' colleagues at the AIDS Clinical Center in Japan found the 172K polymorphism by accident. The mutation was first discovered in a patient, and the researchers were able to recreate it in the laboratory.


'/>"/>
Contact: Tim Wall
walltj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. HIF gene mutation found in tumor cells offers new clues about cancer metabolism
2. Genome-wide scan maps mutations in deadly lung cancers; reveals embryonic gene link
3. Anti-HIV drug simulation offers realistic tool to predict drug resistance and viral mutation
4. Genetic analyses reveal novel mutations as causes of startle disease
5. Genetic mutations that cause common childhood brain tumors identified
6. Hundreds of random mutations in leukemia linked to aging, not cancer
7. Evolutionary information improves discovery of mutations associated with diseases
8. Uncommon BRAF mutation in melanoma sensitive to MEK inhibitor drug therapy
9. Mutation in gene IDH a possible target for AML treatment
10. Gene Mutation Linked to Facial, Skull Abnormalities
11. Study finds new gene mutations that lead to enlarged brain size, cancer, autism, epilepsy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... April 29, 2016 , ... ... flexibility in repaying their loans, more information about their loan terms and accounts, ... outstanding student loan debt, including federal and private loans, has reached $1.3 trillion, ...
(Date:4/29/2016)... ... 29, 2016 , ... The Wharton School of the ... Prize of the 2016 Wharton Business Plan Competition —as well as the ... and the Committee Award for Most ‘Wow Factor,’ making them the first team ...
(Date:4/29/2016)... ... , ... Dr. Robert Mondavi, one of the dentists in Torrance , ... fast-growing field as more patients are discovering the many different ways they can change ... currently available to them and which ones might work for their smiles. , ...
(Date:4/29/2016)... , ... April 29, 2016 , ... ... Grassland Dairy Products, Inc. in an upcoming episode, airing third quarter 2016 via ... of churning cream into butter, Grassland Dairy Products, located in Greenwood, Wisconsin applies ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... Expo to promote their animal line of probiotics, Petbiotics ™, as they ... large turnout of animal rescue groups networking for their non-profit organizations. Animal rescues ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 Oramed ... a clinical-stage pharmaceutical company focused on the development of oral ... in the upcoming PIONEERS 2016 conference, presented by Joseph ... 2016 in New York . Nadav ... at the conference. Presentation Details:   ...
(Date:4/27/2016)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... second quarter ended March 26, 2016.  GAAP diluted ... and non-GAAP diluted EPS of $0.47 increased 14.6%.  ... reported basis, and 6.3% on a constant currency ... quarter, highlighted by 14.6% growth in non-GAAP EPS," ...
(Date:4/27/2016)... New York , April 27, 2016 ... market report titled, "Skincare Devices Market - Global Industry ... 2023." According to the report, the global skincare devices ... and is anticipated to expand at a CAGR of ... Mn in 2023. Browse the full Skincare Devices ...
Breaking Medicine Technology: