Navigation Links
Mutated Suppressor Gene Leads to a Type of Breast Cancer
Date:12/10/2007

Finding could lead to new treatments, researchers say

MONDAY, Dec. 10 (HealthDay News) -- Scientists believe they've discovered how mutations in the cancer-susceptibility gene called BRCA1 can cause some breast cancers.

Basal-like breast cancers (BBCs) represent 10 percent to 20 percent of all breast cancers. BBCs generally have a poor prognosis, are difficult to treat, and are almost always associated with hereditary mutations in the BRCA1 gene, the researchers said.

The researchers found that inherited mutations in the BRCA1 gene deactivate another gene known as PTEN, which helps to suppress tumors. This suppressor gene is deactivated by the mutated BRCA1 gene's failure to repair a break in the PTEN gene's DNA, the scientists said.

The loss of the PTEN gene's tumor-suppressing ability allows increased cell activity that increases tumor growth. That action "can convert the cell from being a well-behaving entity to a bad citizen," said study co-author Dr. Ramon Parsons, a professor of medicine and pathology at Columbia University's College of Physicians and Surgeons.

"This is a very important finding, because this type of breast cancer doesn't have a type of therapy targeted at this point," Parsons said. Basal-like or triple negative tumors don't have receptors for the hormones estrogen and progesterone or the protein HER2, which most breast cancer therapies target, he said. Drugs that can target the pathway related to mutated PTEN genes "may be a way we can improve the survival for women with these basal-like tumors," he added.

Parsons said several pharmaceutical companies already are developing drugs to do just that.

"My guess is there's going to be a huge bolus of clinical trials with these drugs in the next couple of years," he said. "Since there's going to be such a large variety of compounds, my hunch is one or more will be effective." By effective, Parson said he doesn't mean one of them will offer a cure, but the drugs in the right combination could lead to a cure.

The development of these drugs also may be important for other types of cancers that can involve deactivating the PTEN gene, Parsons said.

The study results were published online Dec. 9 in the journal Nature Genetics.

Parsons said the discovery of the PTEN deactivation "was kind of a real long-term detective story." For 10 years, researchers have been trying to understand how the mutation in the BRCA1 gene can cause breast cancer. Instead of using traditional gene-sequencing techniques, Parsons and his colleagues looked for physical breaks in the PTEN gene. "PTEN is actually physically broken in half, we estimate, in 30 to more than 50 percent of the BRCA1 tumors," he said.

Dr. Jeffrey Weitzel, an associate professor of medical oncology at the City of Hope Comprehensive Cancer Center in Duarte, Calif., said the study by Parsons' team "helps us understand what's under-appreciated in the complex nature of tumor changes."

Andrew Godwin, director of the clinical molecular genetics laboratory at the Fox Chase Cancer Center in Philadelphia, added: "As we move towards personalized health care [and] medicine, identifying the cadre of genetic defects in a given breast tumor will likely influence how that patient is ultimately treated."

More information

For more on breast cancer, visit the U.S. National Cancer Institute.



SOURCES: Andrew Godwin, Ph.D., director, Clinical Molecular Genetics Laboratory and the Biosample Repository, Fox Chase Cancer Center, Philadelphia; Ramon Parsons, M.D., Ph.D., director of the Breast Cancer Program of the Herbert Irving Comprehensive Cancer Center of Columbia University Medical Center and New York-Presbyterian Hospital, and professor of medicine and pathology, Columbia University College of Physicians and Surgeons, New York City; Jeffrey Weitzel, M.D., associate professor of medical oncology, director, department of clinical cancer genetics, City of Hope Comprehensive Cancer Center, Duarte, Calif.; Dec. 9, 2007, Nature Genetics, online


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Study details regulation of vital tumor suppressor gene p53
2. M. D. Anderson researchers identify tumor-suppressor gene for lung cancer
3. Removing Ovaries Before Menopause Leads to Memory, Movement Troubles
4. Lack of sleep among new school-goers leads to behavioral, cognitive problems
5. Olympic Gold Medalist Marion Jones-Thompson Pleads Guilty to Making False Statements in Two Separate Federal Criminal Investigations
6. AstraZeneca Leads Local Walking Movement
7. Leeza Gibbons Leads New Coaching Program to Boost the Nations Heart Health
8. Support System Leads to Better Diet, Nutrition
9. Brain atrophy in elderly leads to unintended racism, depression and problem gambling
10. Medical University of South Carolina Leads Multicenter Study Evaluating Biliary Sphincter Disorder
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mutated Suppressor Gene Leads to a Type of Breast Cancer
(Date:4/29/2016)... ... April 29, 2016 , ... Regenerative Medicine Solutions ... to Work employee satisfaction survey, earning them second place for Tampa’s Best Places to ... employees. , “This is a great accomplishment for our team,” says RMS Human ...
(Date:4/29/2016)... ... , ... International Dehydrated Foods, Inc. (IDF™) will attend and sponsor Global Food ... by Hilton Hotel in Oak Brook, Illinois. The two-day event is the largest conference ... , At the seminar, IDF™ will offer samples of its Savory Bone Broth ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Society for ... reproductive endocrinologists are required to report in vitro fertilization (IVF) delivery ... to the practice of assisted reproductive technologies in the United States. , ...
(Date:4/29/2016)... ... 29, 2016 , ... Orthodontics Limited, one of the nation’s ... Dr. Middleberg, were asked by Invisalign to present an “Ask the ... titled “Advancing the Biomechanics of Invisalign Clear Aligners,” Dr. Gemmi and Dr. Middleberg ...
(Date:4/28/2016)... ... April 28, 2016 , ... ProText Layouts is a set of ... X . With ProText Layouts, video editors can create an energetic typography video ... and scale of texts. Creating text-based videos have never been easier. , ProText ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016   Acsis , a leading provider of ... market research and advisory firm IDC has named it ... Worldwide Pharmaceutical Track and Trace Software 2016 Vendor Assessment ... assessment of the capabilities and business strategies of 10 ... Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/28/2016)... , April 28, 2016 ... development of innovative peptide and gene-based immunotherapeutics and vaccines for ... will be presenting at the 3rd Annual Growth Capital ... 5 th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... am on Wednesday, May 4 th by Dr. ...
(Date:4/27/2016)... April 27, 2016  Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended March ... of $0.24 increased 41.2%, and non-GAAP diluted EPS ... increased 5.8% on a reported basis, and 6.3% ... "We posted another good quarter, highlighted by 14.6% ...
Breaking Medicine Technology: