Navigation Links
Mutated Kras spins a molecular loop that launches pancreatic cancer
Date:1/26/2012

n and regulates a number of inflammation-promoting genes, including IL-1α.
  • IL-1α and another protein called p62 activate NF-κB which in turn cycles back to perpetuate the loop by activating its activators.

    "It's a vicious cycle," Chiao said. The overactive NF-κB fuels pancreatic cancer by activating genes that promote inflammation, the growth of new blood vessels and block programmed cell death.

    Chiao has three research grants from the National Cancer Institute to study pancreatic cancer. "We study signaling transduction pathways to try to find out why it's such a bad disease and to find a weak point for targeted therapy," he said.

    In the Cancer Cell paper, the authors conclude: "Our findings suggest that the prime mover responsible for cancer-related inflammatory response and the development of pancreatic intraepithelial neoplasia (precancerous lesions) and pancreatic ductal adenocarcinoma is the mutant Kras-initiated constitutive activation of NF-κB."

    This process, they further noted, creates a pro-tumor microenvironment by promoting inflammation, creation of new blood vessels and tissue repair that is similar to conditions found in inherited pancreatitis, inflammation of the pancreas that is linked to the development of cancer.

    Kras mutation, IL-1α, NF-κB go together with poor survival

    The team analyzed mouse and human tumors and mouse strains with mutated Kras expressed in their pancreases. In a series of experiments they found:

    • Active IKK2/ the activator of NF-κB was required for the Kras-mutated mice to develop either pancreatic cancer or precancerous legions.
    • Deletion of IKK2/Beta interrupted Kras-stimulated inflammation and cell proliferation, suggesting that chronic inflammation is a key factor in promoting pancreatic cancer development.
    • Microarray profiles of gene expression showed that several NF-κB-regu
      '/>"/>

    Contact: Scott Merville
    smerville@mdanderson.org
    713-792-0661
    University of Texas M. D. Anderson Cancer Center
    Source:Eurekalert  

    Page: 1 2 3

    Related medicine news :

    1. Single Lung Tumor Contains 50,000 Mutated Genes
    2. Targeted drug leads to regression of metastatic melanoma with mutated BRAF gene
    3. Mouse model confirms mutated proteins role in dementia
    4. When leukemia returns, gene that mediates response to key drug often mutated
    5. Mutated gene found in dog disease the same in humans, MU researchers find
    6. Molecular pathways linked to sex, age affect outcomes in lung cancer
    7. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
    8. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
    9. The Association for Molecular Pathology celebrates ruling in DNA patent case
    10. USC researchers discover new molecular subtype of brain cancer
    11. Molecular discovery points to new therapies for brain tumors
  • Post Your Comments:
    *Name:
    *Comment:
    *Email:
    Related Image:
    Mutated Kras spins a molecular loop that launches pancreatic cancer
    (Date:5/30/2015)... Luis Obispo, CA (PRWEB) May 30, 2015 ... Polk announced today that she is offering a free ... , The offer coincides with Disability Awareness Month, ... Happens . Industry members across the United States such ... a time to raise awareness about the possibility of ...
    (Date:5/30/2015)... May 30, 2015 This year the ... with Pulmonary Horizons to offer one of the most ... and discuss successful practices to diagnose, treat and manage ... Pulmonary Horizons Conference is Interaction with Multidisciplinary ... the Overall Needs of Patients with COPD," said Brian ...
    (Date:5/30/2015)... Venus Viva has proven to work in ... wrinkles, stretch marks, pigmentation irregularities, and uneven texture when ... F. Victor Rueckl of Lakes Dermatology in Las Vegas ... Vegas. This body image solution combines NanoFractional Radio Frequency ... proven results through a skin heating process that offers ...
    (Date:5/29/2015)... 30, 2015 “In the current ... and federal regulations, we provide education that will ... who are suffering from pain, within the boundaries ... MD, professor of rehabilitation medicine and President/Medical Director ... Park, Kansas. , A new flight of PAINWeekEnd ...
    (Date:5/29/2015)... What does community do? , According to a ... to plant gardens, to teach young people, to laugh, ... issues. Community invites everyone to help improve lives for ... Does" was commissioned by The Denver Foundation, the largest ... the foundation’s Annual Celebration in May. At just over ...
    Breaking Medicine News(10 mins):Health News:San Luis Obispo Insurance Agent Susan Polk Offering Complementary Insurance Analysis In Honor Of Disability Awareness Month 2Health News:Pulmonary Horizons 2nd Annual COPD Conference Miami Hilton Downtown, July 17-19, 2015 Patient Centered Cross-Continuum Education to Improve the Care of Patients with COPD 2Health News:Pulmonary Horizons 2nd Annual COPD Conference Miami Hilton Downtown, July 17-19, 2015 Patient Centered Cross-Continuum Education to Improve the Care of Patients with COPD 3Health News:Announcing Ground-Breaking Technology for Anti-Aging, FDA Approved, Venus Viva. 2Health News:Announcing Ground-Breaking Technology for Anti-Aging, FDA Approved, Venus Viva. 3Health News:PAINWeekEnd Kansas City: Pain Management CME for the Main Street Practitioner 2Health News:What Community Does: A New Video from The Denver Foundation 2
    ... ZEELAND, Mich., Dec. 19 Herman Miller, Inc.,announced ... Inc.,a Seattle-based manufacturer of healthcare furnishings. The transaction ... the conclusion of due,diligence. Terms of the transaction ... of healthcare furnishings, with an emphasis,on seating products ...
    ... Delta Dental of Illinois has made,a ... Illinois at Chicago,College of Dentistry to modernize ... are complete, the clinic will be named ... Clinic., (Photo: http://www.newscom.com/cgi-bin/prnh/20071219/AQW128 ), ...
    ... SCHAUMBURG, Ill., Dec. 19 The American,Veterinary Medical ... the Veterinary Workforce Grant Program (VWGP) as part ... program will help ensure an,adequate supply of public ... "The Farm Bill is vitally important to rural ...
    ... new molecular pathway that appears to be involved in ... 100 million people around the world and is caused ... Blocking this pathway could be a treatment for the ... failure. The research teams findings will appear in ...
    ... a big impact on behavior, studies show , , WEDNESDAY, Dec. ... its 1 trillion cells, looking for perhaps only one or ... a trio of new studies says. , The research, conducted ... Nature , could rewrite the textbooks on just how ...
    ... Researchers here have figured out a way to use ... a new drug combination actually is against some forms of ... looked at ATLL, adult T-cell lymphoma and leukemia, a form ... disease,s progress, and where the patients, prognosis is generally poor. ...
    Cached Medicine News:Health News:Herman Miller, Inc., Announces Strategic Acquisition of Brandrud Furniture, Inc. to Expand Its Product Offerings and Competitive Position in the Healthcare Furnishings Sector 2Health News:Herman Miller, Inc., Announces Strategic Acquisition of Brandrud Furniture, Inc. to Expand Its Product Offerings and Competitive Position in the Healthcare Furnishings Sector 3Health News:Delta Dental of Illinois Announces Major Gift to University of Illinois at Chicago College of Dentistry 2Health News:AVMA Lauds Senators for Approving 2007 Farm Bill Legislation that Includes the Veterinary Workforce Grant Program 2Health News:Receptor protein appears to be key in breakdown of kidney filtration 2Health News:Receptor protein appears to be key in breakdown of kidney filtration 3Health News:Brain Cells More Powerful Than You Think 2Health News:Brain Cells More Powerful Than You Think 3Health News:Brain Cells More Powerful Than You Think 4Health News:Firefly genes allow testing of new therapy against lymphoma 2Health News:Firefly genes allow testing of new therapy against lymphoma 3
    (Date:5/29/2015)... NORTHBROOK, Ill. , May 29, 2015 /PRNewswire/ ... and MasterControl, a leading global provider of electronic ... announce a collaborative agreement which will leverage the ... industry with both quality system implementation and comprehensive ... Adding MasterControl,s EQMS capabilities to UL,s ...
    (Date:5/29/2015)... Research and Markets ( http://www.researchandmarkets.com/research/64lx2w/north_america_mri ) has ... Market - Growth, Trends And Forecasts (2014 - 2019)" ... American MRI systems market is estimated to increase from ... by 2020 with a CAGR of 2.9% between 2014 ... the open system, closed system and the standing or ...
    (Date:5/29/2015)... 2015 Actinobac Biomed, NovoPedics, Inc. and MentiNova, ... from Foundation Venture Capital Group (FVCG), have been selected ... part of the Start-Up Stadium and Company Presentation forums ... M. Golubieski . The annual convention, the ... held in Philadelphia in June. ...
    Breaking Medicine Technology:UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 2UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 3North America MRI Market - Growth, Trends And Forecasts 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare & Toshiba Medical Systems Dominating 2Foundation Venture Capital Group Portfolio Companies to be Highlighted at Bio International in June 2Foundation Venture Capital Group Portfolio Companies to be Highlighted at Bio International in June 3
    ... 25 The U.S. Food and Drug Administration is ... contains an active drug ingredient that can dangerously lower ... supplement for sexual enhancement. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ... TimeOut is labeled as "100% natural" and consumers may ...
    ... Aug. 25 Ambry Genetics, a global leader in ... Illumina HiSeq 2000 Next Generation Sequencing System as well ... System. Ambry Genetics has been an early adapter of ... as a Certified Service Provider. A team of scientists ...
    Cached Medicine Technology:FDA Warns Consumers to Avoid TimeOut Capsules 2Ambry Genetics Announces the Addition of Illumina HiSeq 2000 and First 510(K) Approved BeadXpress® to Its Sequencing and Genotyping Capabilities 2
    ... Built-in, motor-driven internal calibration mass for ... Self-Calibration when temperature change detected and ... weighing parameters, plug-in peripherals, and easy ... this balance series highly accurate and ...
    Can download data from your A&D balance directly to your PC saving time and reducing the chances of manually recording the wrong weighing data; 60 month warranty; automatic adjustable environment set...
    ... DNA sequencing reagents including linear polyacrylamide ... cyanine-based infrared dyes- coupled with online denaturation. ... meaningful raw data, and higher-quality final analyses. ... 8800 to resolve complex sequences, filling in ...
    ... 3100 system offers continuous, unattended operation ... separation and detection, and data analysis. ... and importing sample information, the operator ... Run command. The instrument requires no ...
    Medicine Products: