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Mutant proteins result in infectious prion disease in mice
Date:12/5/2008

ain," said Sigurdson. "We also found that by transferring brain tissue from mice with the mutant protein into mice expressing the normal mouse prion protein, we could transmit the neurologic disease between the two groups of animals."

According to Sigurdson, the discovery that an infectious disease can be generated through just two mutations in the prion gene is of particular interest. "Some forms of prion disease in humans caused by genetic mutations have also been shown to be infectious," she said. "This new mouse model of the disease may be useful in our understanding of how the misfolded protein leads to neurodegeneration and for testing new therapies against prion disease."


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Contact: Debra Kain
ddkain@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2

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